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[ 作者:基础医学研究所(院)    来源自:本站原创    点击数:26298    更新时间:2017-9-7    文章编辑:wangluo ]

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黄波

导师简介
    黄波,中国医学科学院基础医学研究所&北京协和医学院协和学者特聘教授,博士生导师,同时系华中科技大学同济医学院生物化学与分子生物学系教授、博导。现任中国医学科学院基础医学研究所副所(院)长,北京协和医学院免疫学系副主任,中国免疫学会副秘书长。1999年和2002年先后在华中科技大学同济医学院获得生物化学与分子生物学硕士和博士学位。2002年5月至2006年2月先后在Karolinska  Institute(乳腺癌的遗传学)、加拿大University of Calgary(脑胶质瘤的生物学)、美国Mount Sinai School of Medicine(肿瘤免疫学和免疫治疗)从事博士后研究。回国后,2008年破格晋升为教授、博士生导师。先后获得首届“中国免疫学青年学者奖”、“教育部新世纪优秀人才支持计划”资助、“湖北省有突出贡献的中青年专家”称号、中国医学科学院和北京协和医学院协和学者特聘教授、“国家杰出青年基金”资助、“国家百千万人才和有突出贡献中青年专家”称号,并入选国家万人计划。2014年入选教育部“长江学者特聘教授”。现任中国免疫学会常务理事以及中国生物化学与分子生物学会理事,中国抗癌协会肿瘤生物治疗专业委员会委员,并担任European Journal of Immunology、Cancer Letters等杂志的编委。

实验室简介
    实验室自2008年成立以来,主要研究肿瘤免疫,肿瘤生物治疗,生物机械力,肿瘤休眠,肿瘤代谢等前沿医学科学问题。先后在Nature Materials、Nature Communications、Blood、EMBO Reports、Cancer Research、Cancer Immunology Research、Oncoimmunology、Journal of Immunology等相关领域国际主流杂志发表SCI文章60多篇,50多篇论文的影响因子>5.0, SCI引用2000余次。实验室目前有副教授/副研究员3名,在站博士后3名,博士研究生15名,硕士研究生6名。
实验室网站链接:http://huangbolab.cn/

代表性论文

2017  Publications

  1. Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Liu N, Zhang Y, Sun Y, Ji T, Liang X, Yin X, Liu Y, Tong W, Niu Y, Wang N, Wang X,Huang Bo*. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene. 2017 Jun 22;36(25):3609-3617. (IF:7.932)
  2. Sun Y, Zheng Z, Zhang H, Yu Y, Ma J, Tang K, Xu P, Ji T, Liang X, Chen D, Jin X, Zhang T, Long Z, Liu Y, Huang Bo*. Chemotherapeutic tumor microparticles combining low dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway. Oncoimmunology. 2017 Mar 31;6(6):e1309487. (IF:7.644)
  3. Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin J, Chen D, Li Y, Zhang S, Xie H, Zhao B, Zhao T, Lu J, Hu Z, Cao X, Qin X, Huang Bo*. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nat Commun. 2017 May 10;8:15207. (IF:12.123)
  4. Dong W, Zhang H, Yin X, Liu Y, Chen D, Liang X, Jin X, Lv J, Ma J, Tang K, Hu Z, Qin X, Huang Bo*. Oral delivery of tumor microparticle vaccines activates NOD2 signaling pathway in ileac epithelium rendering potent antitumor T cell immunity. OncoImmunology. 2017 Jan 19;6(3):e1282589. (IF:7.644)
  5. Jin X, Ma J, Liang X, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang Bo*. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 2017 Jan;113:93-104. (IF=8.402)

2016  Publications

  1. Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, Chen J, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J, Hu Z, Cao X, Wang N, Yang X, Huang Bo*. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res. 2016 Jun;26(6):713-27.(IF=15.606)
  2.  Ran L, Tan X, Li Y, Zhang H, Ma R, Ji T, Dong W, Tong T, Liu Y, Chen D, Yin X, Liang X, Tang K, Ma J, Zhang Y, Cao X, Hu Z, Qin X,Huang Bo* . Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. Biomaterials. 2016 May;89:56-66. (IF=8.402)
  3. Ma R, Ji T, Chen D, Dong W, Zhang H, Yin X, Ma J, Liang X, Zhang Y, Shen G, Qin X, Huang Bo*. Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression.  Oncoimmunology. 2016 Feb 18;5(4):e1118599. (IF=7.644)
  4. Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang Bo, Xu X, Zheng J, Cao X. Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils. Cancer Cell. 2016 Aug 8;30(2):243-56. (IF:27.407)

2015 Publications

  1. Tang K, Hu L, Ma J, Zhang H, Zhang Y, Li Y, Ma R, Luo S, Liu D, Long G, Han M, Liu S, Song A, Shen M, Hu G, Huang Bo*. Brief Report: Human Mesenchymal Stem-Like Cells Facilitate Floating Tumorigenic Cell Growth via Glutamine-Ammonium Cycle. Stem Cells. 2015 Sep;33(9):2877-84. (IF: 5.599)
  2. Wang Z, Cheng Q, Tang K, Sun Y, Zhang K, Zhang Y, Luo S, Zhang H, Ye D, Huang Bo*. Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells. Cancer Lett. 2015 Aug 10;364(2):118-24. (IF: 6.375)
  3. Zhang H & Huang Bo*. Tumor cell-derived microparticles: a new form of cancer vaccine. Oncoimmunology. 2015 May 27;4(8):e1017704.(IF=7.644)
  4. Cao Y, Liu C, Gu Z, Zhang Y, Duan Y, Zhang Y, Zhang H, Tang K, Huang Bo*. Microparticles mediate human papillomavirus type 6 or 11 infection of human macrophages.Cell Mol Immunol. 2015 Apr 20. (IF: 5.897)
  5. Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y, Liang X, Sun Y, Ji T, Wang N, Huang Bo*. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors. Cancer Res. 2015 Apr 1;75(7):1191-6. (IF: 9.122)
  6. Zhang H, Tang K, Zhang Y, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z, Lu J, He W, Cao X, Wan Y, Huang Bo*. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res. 2015 Feb;3(2):196-205. (IF: 8.284)
  7. Huang Bo*. Tumor microenvironment: a mechanical force link. Sci China Life Sci. 2015 Feb;58(2):202-4. (IF: 2.781)
  8. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang Bo, Jiang JD, Hu ZW. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun. 2015 Aug 13;6:7951. (IF:12.123)

2014 Publications

  1. Zhao J, Zeng W, Cao Y, Liang X, Huang Bo*. Immunotherapy of HPV infection-caused genital warts using low dose cyclophosphamide. Expert Rev Clin Immunol. 2014 Jun;10(6):791-9. (IF: 3.27)
  2. Tan Y, Tajik A, Chen J, Jia Q, Chowdhury F, Wang L, Chen J, Zhang S, Hong Y, Yi H, Wu D, Zhang Y, Wei F, Poh Y, Seong J, Singh R, Lin LJ, Doğanay S, Li Y, Jia H, Ha T, Wang Y, Huang Bo, Wang N. Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nat Commun. 2014 Aug 6;5:4619. (IF:12.123)

2013 Publications

  1. Ma R, Zhang W, Tang K, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, Ji T, Katirai F, Ye D, Huang B*. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 2013;4:2508. (IF: 12.123)
  2. Li D, Cai W, Gu R, Zhang Y, Zhang H, Tang K, Xu P, Katirai F, Shi W, Wang L, Huang T, Huang B*. Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin Immunol. 2013;149(3):411-20. (IF:4.034)
  3. Ma J, Cai W, Zhang Y, Huang C, Zhang H, Liu J, Tang K, Xu P, Katirai F, Zhang J, He W, Ye D, Shen GX, Huang B*. Innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin αMβ2 to tumor cells. J Immunol. 2013;191:3453-61. (IF: 4.856)
  4. Xu Z, Zhao J, Zhang H, Ke T, Xu P, Cai W, Katirai F, Ye D, Huang Y, Huang B*. Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis. J Immunol. 2013;190:6051-8. (IF: 4.856)

2012 Publications

  1. Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater. 2012;11:734-41. (IF: 39.737)
  2. Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D, Katirai F, Shen GX, Zhang G, Feng ZH, Ye D, Huang B*. Delivery of chemotherapeutic drugs in tumour cell-derived microparticles. Nat Commun. 2012;3:1282. (IF: 12.123)
  3. Zhang Y, Zhang R, Zhang H, Liu J, Yang Z, Xu P, Cai W, Lu G, Cui M, Schwendener RA, Shi HZ, Xiong H, Huang B*. Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity. Cell Mol Immunol. 2012;9:489-96. (IF: 5.897)
  4. Li D, Jia H, Zhang H, Lv M, Liu J, Zhang Y, Huang T, Huang B*. TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b. Oncoimmunology. 2012;1:687-693. (IF: 7.644)
  5. Lv M, Zhang X, Jia H, Li D, Zhang B, Zhang H, Hong M, Jiang T, Jiang Q, Lu J, Huang X, Huang B*. An oncogenic role of miR-142-3p in human T cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor alpha and cAMP/PKA pathways. Leukemia. 2012;26:769-77. (IF: 12.104)

2011 Publications

  1. Liu J, Zhao J, Hu L, Cao Y, Huang B*. Low Dosages: new chemotherapeutic weapons on the battlefield of immune-related diseases. Cell Mol Immunol. 2011;8:289-95. (IF: 5.897)
  2. Liu J, Zhang Y, Zhao J, Yang Z, Li D, Katirai F, Huang B*. Mast cell: insight into remodeling a tumor microenvironment. Cancer Metastasis Rev. 2011;30:177-84. (IF: 4.697)
  3. Ouyang X, Yang Z, Zhang R, Arnaboldi P, Lu G, Li Q, Wang W, Zhang B, Cui M, Zhang H, Liang-Chen J, Qin L, Zheng F, Huang B*, Xiong H*. Potentiation of Th17 cytokines in aging process contributes to the development of colitis. Cell Immunol. 2011;266:208-17. (IF: 3.172)

2010 Publications

  1. Zhang B, Jia H, Liu J, Yang Z, Jiang T, Tang K, Li D, Huang C, Ma J, Shen GX, Ye D, Huang B*. Depletion of T regulatory cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. J Immunol. 2010;185:7199-206. (IF: 4.856)
  2. Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, Shen GX, Ye D, Huang B*. Microparticles mediate enzyme transfer from platelets to mast cells: A new pathway for lipoxin A4 biosynthesis. Biochem Biophys Res Commun. 2010;400:432-6. (IF: 2.446)
  3. Zhao J, Cao Y, Lei Z, Yang Z, Zhang B, Huang B*. Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels. Cancer Res. 2010;70:4850-8. (IF: 9.122)
  4. Cao Y, Zhao J, Yang Z, Cai Z, Zhang B, Zhou Y, Shen GX, Chen X, Li S, Huang B*. CD4+FOXP3+ regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomataacuminata after laser therapy. Clin Immunol. 2010;136:21-29. (IF: 4.034)
  5. Zhou Y, Wang S, Ma JW, Lei Z, Zhu HF, Lei P, Yang ZS, Zhang B, Yao XX, Shi C, Sun LF, Wu XW, Ning Q, Shen GX, Huang B*. HBx-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem. 2010;285:12159-68. (IF: 4.125)
  6. Yang Z, Zhang B, Li D, Lv M, Huang C, Shen GX, Huang B*. Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS One. 2010;5:e8922. (IF: 2.806)
  7. Li B, Lei Z, Lichty BD, Li D, Zhang GM, Feng ZH, Wan Y, Huang B*. Autophagy facilitates major histocompatibility complex class I expression induced by IFN-gamma in B16 melanoma cells. Cancer Immunol Immun. 2010;59:313-21. (IF: 4.711)
  8. Yang Z, Lei Z, Li B, Zhou Y, Zhang GM, Feng ZH, Zhang B, Shen GX, Huang B*. Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling. Cancer Sci. 2010; 101:494-500. (IF: 3.974)

2009 Publications

  1. Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B*. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One. 2009; 4:e7629. (IF:2.806)
  2. Zhao J, Lei Z, Liu Y, Li B, Zhang L, Fang H, Song C, Wang X, Zhang GM, Feng ZH, Huang B*. Human Pregnancy Upregulates Tim-3 in Innate Immune Cells for Systemic Immunity. J Immunol. 2009; 182:6618-24. (IF: 4.856)
  3. Huang B*, Zhao J, Lei Z, Shen S, Li D, Shen GX, Zhang GM, Feng ZH*. miR-142-3p Regulates cAMP Production in T cells by Targeting Adenylyl Cyclase 9 mRNA. EMBO Rep. 2009; 10:180-5. (IF: 8.568)
  4. Lei Z, Zhang GM, Hong M, Feng ZH, Huang B*. Fusion of dendritic cells and CD34+CD38- acute myeloid leukemia (AML) cells potentiates targeting AML-initiating cells by specific CTL induction. J Immunother. 2009; 32:408-14. (IF: 3.712)

2008 Publications

  1. Song C, Luo L, Lei Z, Li B, Liang Z, Liu G, Li D, Zhang G, Huang B*, Feng ZH*. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol. 2008; 181:6117-24. (IF: 4.856)
  2. Huang B*, Lei Z, Zhang GM, Li D, Song C, Li B, Liu Y, Yuan Y, Unkeless J, Xiong H, Feng ZH*.SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood. 2008; 112:1269-79. (IF: 11.840)
  3. Gong W, Zhang GM, Liu Y, Lei Z, Li D, Yuan Y, Huang B*, Feng ZH*. IFN-γ withdrawal after immunotherapy potentiates B16 melanoma invasion and metastasis by intensifying tumor integrin αvβ3 signaling. Int J Cancer. 2008; 123:702-708. (IF: 6.513)
  4. Cao Y, Zhao J, Lei Z, Shen S, Liu C, Li D, Liu J, Shen GX, Zhang GM, Feng ZH, Huang B*. Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata. J Immunol. 2008; 180:7681-6. (IF: 4.856)
  5. Lei Z, Liu G, Huang Q, Lv M, Zu R, Zhang GM, Feng ZH, Huang B*. SCF and IL-31 rather than IL-17 and BAFF are potential indicators in patients with allergic asthma. Allergy. 2008; 63:327-32. (IF: 7.361)
  6. Huang B*, Zhao J, Unkeless JC, Feng ZH, Xiong H*. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene. 2008; 27:218-24. (IF: 7.932)

2007 Publications

  1. Xiao H, Huang B(co-first author), Yuan Y, Li D, Han LF, Liu Y, Gong W, Wu FH, Zhang GM, Feng ZH. Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo. Clin Cancer Res. 2007; 13:1823-30. (IF: 9.619)
  2. Liu Y, Huang B (co-first author), Yuan Y, Gong W, Xiao H, Li D, Yu ZR, Wu FH, Zhang GM, Feng ZH.Inhibition of hepatocarcinoma and tumor metastasis to liver by gene therapy with recombinant CBD-HepII polypeptide of fibronectin. Int J Cancer. 2007; 121:184-92. (IF: 6.513)
  3. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, Zhang GM, Xiong H, Feng ZH. Listeria monocytogenes promotes tumor growth via tumor cell Toll-like receptor 2 signaling. Cancer Res. 2007; 67:4346-52. (IF: 9.122)
  4. Huang B, Lei Z, Zhao J, Gong W, Liu J, Chen Z, Liu Y, Li D, Yuan Y, Zhang GM, Feng ZH. CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett. 2007; 252:86-92. (IF: 6.375)

2006 Publications

  1. Huang B, Pan PY, Li Q, Sato AI, Levy DE, Bromberg J, Divino CM, Chen SH. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor specific T regulatory cell and T cell anergy. Cancer Res. 2006; 66:1123-31. (IF: 9.122)

2005 Publications

  1. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H. Toll like receptor(TLR) on tumor cells facilitate evasion of immune surveillance. Cancer Res. 2005; 65:5009-14. (IF: 9.122)
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