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张业课题组
[ 作者:基础医学研究所(院)    来源自:本站原创    点击数:27115    更新时间:2012-6-19    文章编辑:wangluo ]

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张业,2000年获北京协和医学院博士学位,2000-2003年在哈佛医学院从事博士后研究。2003年回中国医学科学院基础医学研究所暨北京协和医学院生物化学与分子生物学系医学分子生物学国家重点实验室工作,任研究员、博士生导师。2005获得 “教育部新世纪优秀人才计划”。2011年被聘为协和学者特聘教授。主要得到国家自然科学基金和科技部973计划等资助。

 

 

课题组研究方向和兴趣:真核基因表达调控和疾病表观遗传调控机制。本课题组由沈珝琲教授于1985年创建。张业2003年回国后加入,2007年起任课题组长,本课题组一直从事真核基因表达调控研究,近年来侧重于染色质调控机制研究,长远目标为探索重大疾病发生发展过程的表观遗传调控机制。

联系方式:
通讯地址:北京市东城区东单三条5号 邮政编码100005
电话:(010)69155940(326室); 69156416(327室);69155939(356室)
Email:
yezhang@pumc.edu.cn; yz2210@gmail.com
传真:(010)65269665

代表性论文:
1   Zhai N, Zhao ZL, Cheng MB, Di YW, Yan HX, Cao CY, Dai H, Zhang Y* & Shen YF. (2012) Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis, J Mol Cell Biol.
2   Zhao JC, Zhang LX, Zhang Y* & Shen YF. (2012) The differential regulation of Gap43 gene in the neuronal differentiation of P19 cells, J Cell Physiol. 227, 2645-53.
3   Yan L, Zhao HY, Zhang Y* & Shen YF. (2012) Differential effects of AdOx on gene expression in P19 embryonal carcinoma cells, BMC Neurosci. 13, 6.
4   Zhao HY, Zhang YJ, Dai H, Zhang Y* & Shen YF. (2011) CARM1 mediates modulation of Sox2, PLoS One. 6, e27026.
5   Mi Y, Zhang Y* & Shen YF. (2011) Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function, Biochim Biophys Acta. 1812, 1675-80.
6   Zhang Y, Cheng MB, Zhang YJ, Zhong X, Dai H, Yan L, Wu NH, Zhang Y* & Shen YF. (2010) A switch from hBrm to Brg1 at IFNgamma-activated sequences mediates the activation of human genes, Cell Res. 20, 1345-60.
7   Gao X, Pan WS, Dai H, Zhang Y*, Wu NH & Shen YF. (2010) CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells, J Cell Biochem. 110, 162-70.
8   Fang HB, Mi Y, Zhang Y*, Wu NH & Shen YF. (2010) HDAC3 augments the autoregulation of neuroD gene in P19 cells, Neuroreport. 21, 19-23.
9   Dai JP, Lu JY, Zhang Y* & Shen YF. (2010) Jmjd3 activates Mash1 gene in RA-induced neuronal differentiation of P19 cells, J Cell Biochem. 110, 1457-63.
10   Cheng MB, Zhang Y, Zhong X, Sutter B, Cao CY, Chen XS, Cheng XK, Zhang Y*, Xiao L & Shen YF. (2010) Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response, Cell Signal. 22, 1206-13.
11   Zhang Y, Wen G, Shao G, Wang C, Lin C, Fang H, Balajee AS, Bhagat G, Hei TK & Zhao Y. (2009) TGFBI deficiency predisposes mice to spontaneous tumor development, Cancer Res. 69, 37-44.
12   Wu M, Zhang Y*, Wu NH & Shen YF. (2009) Histone marks and chromatin remodelers on the regulation of neurogenin1 gene in RA induced neuronal differentiation of P19 cells, J Cell Biochem. 107, 264-71.
13   Guo Z, Wang J, Yang J, Wu NH, Zhang Y & Shen YF. (2009) An inhibitory role of p53 via NF-kappaB element on the cyclin D1 gene under heat shock, Biochim Biophys Acta. 1789, 758-62.
14   Di Y, Li S, Wang L, Zhang Y & Dorf ME. (2008) Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling, Cell Signal. 20, 705-13.
15   Shen JH, Zhang Y*, Wu NH & Shen YF. (2007) Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells, Neurosci Lett. 414, 110-4.
16   Li ZY, Yang J, Gao X, Lu JY, Zhang Y, Wang K, Cheng MB, Wu NH, Zhang Y, Wu Z & Shen YF. (2007) Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells, J Biol Chem. 282, 18872-8.
17  Chen XS, Zhang Y, Wang JS, Li XY, Cheng XK, Zhang Y, Wu NH & Shen YF. (2007) Diverse effects of Stat1 on the regulation of hsp90alpha gene under heat shock, J Cell Biochem. 102, 1059-66.
18   Li S, Wang L, Berman MA, Zhang Y & Dorf ME. (2006) RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling, Mol Cell. 24, 497-509.
19   Zhang Y, Wang JS, Chen LL, Cheng XK, Heng FY, Wu NH & Shen YF. (2004) Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells, J Biol Chem. 279, 42545-51.
20   Zhang Y, Griffin K, Mondal N & Parvin JD. (2004) Phosphorylation of histone H2A inhibits transcription on chromatin templates, J Biol Chem. 279, 21866-72.
21   Zhai Q, Luo Y, Zhang Y, Berman MA & Dorf ME. (2004) Low nuclear levels of nuclear factor-kappa B are essential for KC self-induction in astrocytes: requirements for shuttling and phosphorylation, Glia. 48, 327-36.
22   Zhang Y, Luo Y, Zhai Q, Ma L & Dorf ME. (2003) Negative role of cAMP-dependent protein kinase A in RANTES-mediated transcription of proinflammatory mediators through Raf, FASEB J. 17, 734-6.
23   Mondal N, Zhang Y, Jonsson Z, Dhar SK, Kannapiran M & Parvin JD. (2003) Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity, Nucleic Acids Res. 31, 5016-24.
24   Zhang Y, Zhai Q, Luo Y & Dorf ME. (2002) RANTES-mediated chemokine transcription in astrocytes involves activation and translocation of p90 ribosomal S6 protein kinase (RSK), J Biol Chem. 277, 19042-8.
25   Luo Y, Berman MA, Zhai Q, Fischer FR, Abromson-Leeman SR, Zhang Y, Kuziel WA, Gerard C & Dorf ME. (2002) RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes, Glia. 39, 19-30.
(* co-correspondence author)

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