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沈岩课题组2000年以来的主要研究工作
[ 作者:基础医学研究所(院)    来源自:本站原创    点击数:27073    更新时间:2009-7-14    文章编辑:wangluo ]

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课题组2000年以来的主要研究工作

1. Yan Wang, Ying Hu, Yue Fang, Kerang Zhang, Hong Yang, Jitang Ma, Qi Xu, and Yan Shen. Evidence of epistasis between catechol-O-methyltransferase gene andaldehyde dehydrogenase 3B1 gene in paranoid schizophrenia. Biological Psychiatry. 2009 Jan 19. [Epub ahead of print]
2. Yan Wang, Yue Fang, Yan Shen, Qi Xu. Analysis of association between the catechol-O- methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia. Psychiatry Research. 2009 April. Accepted.
3. Yan Chen, Liwen Wu, Yue Fang, Zhiyi He, Bingwei Peng, Yan Shen, Qi Xu. A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy. Epilepsy Research. 2009 Feb;83(2-3):152-156. Epub 2008 Dec 5.
4. Juan Zhang, Jun Chen, Qi Xu, Yan Shen. Does the presenilin 2 gene predispose to schizophrenia? Schizophrenia Research. 2009 Apr;109(1-3):121-9. Epub 2009 Feb 15.
5. Zhang K, Xu Q, Xu Y, Yang H, Luo J, Sun Y, Sun N, Wang S, Shen Y.The combined effects of the 5-HTTLPR and 5-HTR1A genes 3 modulates the relationship between negative life events and 4 major depressive disorder in a Chinese population. J Affect Disorders. 2009 Apr;114(1-3):224-31.
6. Sun N, Xu Y, Wang Y, Duan H, Wang S, Ren Y, Peng J, Du Q, Shen Y, Xu Q, Zhang K. The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population. J Neural Transm. 2008 Dec. 115(12):1681-1686. [Epub ahead of print]
7. Shan Wang, Kerang Zhang, Yong Xu, Ning Sun, Yan Shen, Qi Xu. An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population. Psychiatry Research. 2009 March. Accepted.
8. Fan Z, Du J, Liu H, Zhang H, Dlugosz AA, Wang C-Y, Fan M, Shen Y, Wang S. A susceptibility locus on 1p32–1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation. Am J Med Genet Part A, 2009. 149A: 521–524
9. Xie L, Ye L, Ju G, Xu Q, Zhang X, Liu S, Shi J, Yu Y, Wang Z, Shen Y, Wei J. A family- and population-based study of the UFD1L gene for schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5; 147B (7):1076-9.
10. Ke Zou, Jian Liu, Ning Zhu, Jianhong Lin, Qi Liang, W. Ted Brown Yan Shen, Nanbert Zhong. Identification of FMRP-associated mRNAs using yeast three-hybrid system. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2008 Sep 5; 147B(6): 769-77. Epub 2007 Dec 28
11. Lin Zhang, Aihua Hu, Haixin Yuan, Liang Cui, Guobin Miao, Xinchun Yang, Lefeng Wang, Jinchun Liu, Xiulan Liu, Shuyan Wang, Zhiyong Zhang, Lisheng Liu, Rongrui Zhao, Yan Shen. A Missense Mutation in the CHRM2 Gene Is Associated With Familial Dilated Cardiomyopathy. Circ Res. 2008 Jun 6; 102(11): 1426-32. Epub 2008 May 1.
12. Fan Z, Li J, Du J, Zhang H, Shen Y, Wang CY, Wang S. A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a Chinese family. J Med Genet. 2008 May; 45(5): 303-8. Epub 2008 Feb 19.
13. Deng G, Zhou G, Zhang R, Zhai Y, Zhao W, Yan Z, Deng C, Yuan X, Xu B, Dong X, Zhang X, Zhang X, Yao Z, Shen Y, Qiang B, Wang Y, He F. Regulatory polymorphisms in the promoter of CXCL10 gene and disease progression in male hepatitis B virus carriers. Gastroenterology. 2008 Mar; 134(3): 716-26. Epub 2008 Jan 1.
14. Cao WH, Wang XG, Frappart L, Rigal D, Wang ZQ, Shen Y, Tong WM. Analysis of genetic variants of the poly (ADP-ribose) polymerase-1 gene in breast cancer in French patients. Mutation Research. 2007 Aug 15; 632(1-2): 20-8. Epub 2007 Apr 21.
15. Gui-Sen Li, Li Zhu, Hong Zhang, Ji-Cheng Lv, Jia-Xiang Ding, Ming-Hui Zhao, Yan Shen, Hai-Yan Wang. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. Human Mutation, 2007, 28 (10): 950-957.
16. Yan Shen, Qi Xu, Zeguang Han, Han Liu, Guang-Biao Zhou. Analysis of phenotype-genotype connection: the story of dissecting disease pathogenesis in genomic era in China, and beyond. Philosophical Transaction of Royal Society British (Phil Trans R Soc B). 2007, 362: 1043-1061.
17. Xiao-Gan Wang, Zhao-Qi Wang, Wei-Min Tong, Yan Shen. PARP1 Val762Ala polymorphism reduces enzymatic activity. Biochemical and Biophysical Research Communications. 2007, 354: 122-126.
18. Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES; International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S, Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W, Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q, Zhao H, Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A, Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC, Parkin M, Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z, Huang W, Chu X, He Y, Jin L, Liu Y, Shen Y, Sun W, Wang H, Wang Y, Wang Y, Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB, Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F, Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallée C, Verner A, Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon-Miller P, Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T, Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda T, Deloukas P, Bird CP, Delgado M, Dermitzakis ET, Gwilliam R, Hunt S, Morrison J, Powell D, Stranger BE, Whittaker P, Bentley DR, Daly MJ, de Bakker PI, Barrett J, Chretien YR, Maller J, McCarroll S, Patterson N, Pe'er I, Price A, Purcell S, Richter DJ, Sabeti P, Saxena R, Schaffner SF, Sham PC, Varilly P, Altshuler D, Stein LD, Krishnan L, Smith AV, Tello-Ruiz MK, Thorisson GA, Chakravarti A, Chen PE, Cutler DJ, Kashuk CS, Lin S, Abecasis GR, Guan W, Li Y, Munro HM, Qin ZS, Thomas DJ, McVean G, Auton A, Bottolo L, Cardin N, Eyheramendy S, Freeman C, Marchini J, Myers S, Spencer C, Stephens M, Donnelly P, Cardon LR, Clarke G, Evans DM, Morris AP, Weir BS, Tsunoda T, Johnson TA, Mullikin JC, Sherry ST, Feolo M, Skol A, Zhang H, Zeng C, Zhao H, Matsuda I, Fukushima Y, Macer DR, Suda E, Rotimi CN, Adebamowo CA, Ajayi I, Aniagwu T, Marshall PA, Nkwodimmah C, Royal CD, Leppert MF, Dixon M, Peiffer A, Qiu R, Kent A, Kato K, Niikawa N, Adewole IF, Knoppers BM, Foster MW, Clayton EW, Watkin J, Gibbs RA, Belmont JW, Muzny D, Nazareth L, Sodergren E, Weinstock GM, Wheeler DA, Yakub I, Gabriel SB, Onofrio RC, Richter DJ, Ziaugra L, Birren BW, Daly MJ, Altshuler D, Wilson RK, Fulton LL, Rogers J, Burton J, Carter NP, Clee CM, Griffiths M, Jones MC, McLay K, Plumb RW, Ross MT, Sims SK, Willey DL, Chen Z, Han H, Kang L, Godbout M, Wallenburg JC, L'Archevêque P, Bellemare G, Saeki K, Wang H, An D, Fu H, Li Q, Wang Z, Wang R, Holden AL, Brooks LD, McEwen JE, Guyer MS, Wang VO, Peterson JL, Shi M, Spiegel J, Sung LM, Zacharia LF, Collins FS, Kennedy K, Jamieson R, Stewart J. Genome-wide detection and characterization of positive selection in human populations. Nature. 2007 Oct 18; 449(7164): 913-8
19. International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S, Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W, Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q, Zhao H, Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A, Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC, Parkin M, Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z, Huang W, Chu X, He Y, Jin L, Liu Y, Shen Y, Sun W, Wang H, Wang Y, Wang Y, Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB, Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F, Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallée C, Verner A, Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon-Miller P, Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T, Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda T, Deloukas P, Bird CP, Delgado M, Dermitzakis ET, Gwilliam R, Hunt S, Morrison J, Powell D, Stranger BE, Whittaker P, Bentley DR, Daly MJ, de Bakker PI, Barrett J, Chretien YR, Maller J, McCarroll S, Patterson N, Pe'er I, Price A, Purcell S, Richter DJ, Sabeti P, Saxena R, Schaffner SF, Sham PC, Varilly P, Altshuler D, Stein LD, Krishnan L, Smith AV, Tello-Ruiz MK, Thorisson GA, Chakravarti A, Chen PE, Cutler DJ, Kashuk CS, Lin S, Abecasis GR, Guan W, Li Y, Munro HM, Qin ZS, Thomas DJ, McVean G, Auton A, Bottolo L, Cardin N, Eyheramendy S, Freeman C, Marchini J, Myers S, Spencer C, Stephens M, Donnelly P, Cardon LR, Clarke G, Evans DM, Morris AP, Weir BS, Tsunoda T, Mullikin JC, Sherry ST, Feolo M, Skol A, Zhang H, Zeng C, Zhao H, Matsuda I, Fukushima Y, Macer DR, Suda E, Rotimi CN, Adebamowo CA, Ajayi I, Aniagwu T, Marshall PA, Nkwodimmah C, Royal CD, Leppert MF, Dixon M, Peiffer A, Qiu R, Kent A, Kato K, Niikawa N, Adewole IF, Knoppers BM, Foster MW, Clayton EW, Watkin J, Gibbs RA, Belmont JW, Muzny D, Nazareth L, Sodergren E, Weinstock GM, Wheeler DA, Yakub I, Gabriel SB, Onofrio RC, Richter DJ, Ziaugra L, Birren BW, Daly MJ, Altshuler D, Wilson RK, Fulton LL, Rogers J, Burton J, Carter NP, Clee CM, Griffiths M, Jones MC, McLay K, Plumb RW, Ross MT, Sims SK, Willey DL, Chen Z, Han H, Kang L, Godbout M, Wallenburg JC, L'Archevêque P, Bellemare G, Saeki K, Wang H, An D, Fu H, Li Q, Wang Z, Wang R, Holden AL, Brooks LD, McEwen JE, Guyer MS, Wang VO, Peterson JL, Shi M, Spiegel J, Sung LM, Zacharia LF, Collins FS, Kennedy K, Jamieson R, Stewart J. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007 Oct 18; 449(7164): 851-61.
20. Wang L, Lin H, Shen Y, Huang S, Gu J, Su H, Qi Y. A new locus for inherited nuclear cataract mapped to the long arm of chromosome 1. Mol Vis. 2007 Aug 1; 13: 1357-62.
21. Wang QJ, Zhao YL, Rao SQ, Guo YF, Yuan H, Zong L, Guan J, Xu BC, Wang DY, Han MK, Lan L, Zhai SQ, Shen Y. A distinct spectrum of SLC26A4 mutations in patients with enlarged vestibular aqueduct in China. Clin Genet. 2007 Sep; 72(3): 245-54.
22. Li GS, Zhang H, Lv JC, Shen Y, Wang HY. Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Kidney Int. 2007; 71(5): 448-53.
23. Liu T, Zhang Q, Wang L, Yu L, Leng W, Yang J, Chen L, Peng J, Ma L, Dong J, Xu X, Xue Y, Zhu Y, Zhang W, Yang L, Li W, Sun L, Wan Z, Ding G, Yu F, Tu K, Qian Z, Li R, Shen Y, Li Y, Jin Q. The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germination. BMC Genomics. 2007 Apr 11;8:100
24. Qiuju Wang, Qingzhong Li, Shaoqi Rao, K Lee, Xusheng Huang, Weiyan Yang, Suoqiang Zhai, Weiwei Guo, Yufen Guo, Ning Yu, Yali Zhao, Hu Yuan, Jing Guan, S M Leal, Dongyi Han, Yan Shen. AUNX1, a novel locus responsible for X linked recessive auditory and peripheral neuropathy, maps to Xq23-27.3. Journal of Medical Genetics, 2006; 43: e33.
25. Chen T, Li Q, Xu J, Ding K, Wang Y, Wang W, Li S, Shen Y.Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. European Journal of Human Genetics, 2007, 15: 23-28. 2006 Sep 27; [Epub ahead of print]
26. Qiu-Ju Wang, Qing-Zhong Li, Shao-Qi Rao, Ya-Li Zhao, Hu Yuan, Wei-Yan Yang, Dong-yi Han, Yan Shen. A Novel Mutation of POU3F4 Causes Congenital Profound Sensorineural Hearing Loss in a Large Chinese Family. Laryngoscope, 2006, 116(6): 944-50.
27. Zhai Y, Zhou G, Deng G, Xie W, Dong X,Zhang X, Yu L, Yang H, Yuan X, Zhang H, Zhi L, Yao Z, Shen Y, Qiang B, He F. Estrogen receptor alpha polymorphisms associated with susceptibility to hepatocellular carcinoma in hepatitis B virus carriers. Gastroenterology, 2006; 130(7): 2001-9.
28. Zhang XY, Tan YL, Cao LY, Wu GY, Xu Q, Shen Y, Zhou DF. Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics. Schizophrenia Research, 2006; 81(2-3): 291-300.
29. Tao R, Wei J, Guo Y, Yu Y, Xu Q, Shi J, Liu S, Ju G, Li Y, Shen Y. The PLA2G4A gene and negative symptoms in a Chinese population. Tao R, Wei J, Guo Y, Yu Y, Xu Q, Shi J, Liu S, Ju G, Li Y, Shen Y. Schizophrenia Research, 2006; 86(1-3): 326-8.
30. Liang J, Zhang Y, Wang J, Pan H, Wu H, Xu K, Liu X, Jiang Y, Shen Y, Wu X. New variants in the CACNA1H gene identified in childhood absence epilepsy. Neuroscience letters, 2006; 406 (1-2): 27-32
31. Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y. A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. Neuroscience Letters, 2006; 402 (1-2): 173-5.
32. Wang J, Zhang Y, Liang J, Pan H, Wu H, Xu K, Liu X, Jiang Y, Shen Y, Wu X. CACNA1I is not associated with childhood absence epilepsy in the Chinese Han population. Pediatr Neurol, 2006, 35(3): 187-90.
33. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA. The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006, 440(7088): 1194-8.
34. Ren L, Jin L, Zhang B, Jia Y, Wu L, Shen Y. Lack of GABA(B)R1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy. Seizure. 2005, 14(8): 611-3.
35. J. Zhou, Y. Lu, X.H. Gao, Y.C. Chen, J.J. Lu, Y.X. Bai, Y. Shen, and B.K. Wang. The Growth Hormone Receptor Gene is Associated with Mandibular Height in a Chinese Population. Journal Dental Research, 2005; 84: 1052-1056.
36. Yejun Cai, Zhipeng Fan, Qingjie Liu, Jingyuan Li, Juan Du, Yan Shen, Songling Wang. Two novel mutations of the NF1 gene in Chinese Han families with type 1 neurofibromatosis. Journal of Dermatological Science, 2005; 39: 125-127.
37. Lipin Hu, Yuting Chen, Stefan Evers, Yan Shen. Analysis of targets interacted with fragile X mental retardation protein by proteomics. Proteomics, 2005; 5(15): 3979-3990.
38. H Sun, Z Ma, Y Li, B Liu, Z Li, X Ding, Y Gao, W Ma, X Tang, X Li, Y Shen. Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans. Journal of Medical Genetics, 2005; 42: 706-710.
39. Vitko, Iuliia; Chen, Yucai; Arias, Juan; Shen, Yan; Wu, Xi-Ru; Perez-Reyes, Edward. Functional Characterization and Neuronal Modeling of the Effects of Childhood Absence Epilepsy Variants in CACNA1H, a T-Type Calcium Channel. Journal of Neuroscience. 2005, 25(19): 4844-55.
40. XuemeiI Zhang, Xiaoping Miao, Wen Tan, Baitang Ning, Zhihua Liu, Yuan Hong, Wenguang Song, Yongli Guo, Xinyu Zhang, Yan Shen, Boqin Qiang, Fred F. Kadlubar, and Dongxin Lin. Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer. Gastroenterology, 2005; 129: 565–576.
41. Xiangqing Sun, Yanbin Jia, Xuegong Zhang,Qi Xu,Yan Shen, Yanda Li. Multi-locus association study of schizophrenia susceptibility genes with a posterior probability methold. Science in China Ser. C Life Sciences, 2005; 48(3): 263-269.
42. Keyue Ding, Jing Zhang, Kaixin Zhou, Yan Shen, Xuegong Zhang. A heuristic algorithm for optimal selecting of haplotype tagging SNPs. BMC Bioinformatics, 2005; 6: 38.
43. Boyu Zhang, Yanbo Yuan, Yanbin Jia, Xin Yu, Qi Xu, Yucun Shen, Yan Shen. An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia. European Psychiatry. 2005, 20: 45-49.
44. Ding K, Zhou K, Zhang J, Knight J, Zhang X, Shen Y. The Effect of Haplotype Block Definitions on Inference of Haplotype Block Structure and htSNPs Selection. Mol Biol Evol. 2005; 22(1): 148-159.
45. Yang F, Yang J, Zhang X, Chen L, Jiang Y, Yan Y, Tang X, Wang J, Xiong Z, Dong J, Xue Y, Zhu Y, Xu X, Sun L, Chen S, Nie H, Peng J, Xu J, Wang Y, Yuan Z, Wen Y, Yao Z, Shen Y, Qiang B, Hou Y, Yu J, Jin Q. Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res. 2005; 33(19): 6445-58.
46. Su SY, Chen JH, Huang JF, Wang XL, Zhao JG, Shen Y, Qiang BQ, Gu DF. Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women. Chin Med J (Engl). 2005; 118(14): 1167-74.
47. Tao R, Yu Y, Zhang X, Guo Y, Shi J, Zhang X, Xie L, Liu S, Ju G, Xu Q, Shen Y, Wei J. Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2005; 137(1): 56-8.
48. Fan Z, Peng K, Tan X, Yin B, Dong X, Qiu F, Shen Y, Wang H, Yuan J, Qiang B, Peng X. Molecular cloning, expression, and purification of SARS-CoV nsp13. Protein Expr Purif. 2005; 41(2): 235-40.
49. Ye L, Sun Z, Xie L, Liu S, Ju G, Shi J, Yu Y, Zhang X, Wei J, Xu Q, Shen Y. Further study of a genetic association between the CLDN5 locus and schizophrenia. Schizophr Res. 2005; 75(1): 139-41.
50. Cao B, Tian X, Li Y, Jiang P, Ning T, Xing H, Zhao Y, Zhang C, Shi X, Chen D, Shen Y, Ke Y. LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China. Carcinogenesis. 2005; 26(7): 1280-4.
51. Ying Hu, Libo Liu,Guizhi Ju, Xuan zhang, Lin Xie, Shuzheng Liu, Jieping Shi, Yanqin Yu, Zhiwei Sun, Yingjun Guo, Qi Xu, Yu Fan, Yan Shen, Jun Wei. An association study of the KPNB3 locus with schizophrenia in a Chinese population. Schizophrenia Research. 2005; 76(2-3): 363-5.
52. Wang X, Huang J, Fan Z, Su S, Zhao J, Shen Y, Qiang B, Gu D. Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese. Int J Mol Med. 2004, 13(3): 445-50.
53. Zhaohui Lu, Liping Hu, Stefan Evers, Jie Chen, Yan Shen. Proteomics of human pancreatic adenocarcinoma. Proteomics. 2004; 4(12): 3975-88.
54. Xi YG, Ding KY, Su XL, Chen DF, You WC, Shen Y, Ke Y. p53 polymorphism and p21WAF1/CIP1 haplotype in the intestinal gastric cancer and the precancerous lesions. Carcinogenesis. 2004; 25(11): 2201-6.
55. Lu JJ, Zhang YH, Pan H, Chen YC, Liu XY, Jiang YW, Bao XH, Shen Y, Wu HS, Xu KM, Wu XR. Case-control study and transmission/disequilibrium tests of the genes encoding GABRA5 and GABRB3 in a Chinese population affected by childhood absence epilepsy. Chin Med J (Engl). 2004; 117(10): 1497-501.
56. Liu LL, Wei J, Zhang X, Li XY, Shen Y, Liu SZ, Ju GZ, Shi JP, Yu YQ, Xu Q, Hemmings GP. Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population. Neuroscience Letter. 2004; 355(1-2): 149-51.
57. Weihong Gu, Huizi Ma, Kang Wang, Miao Jin, Yongxing Zhou, Xingzhou Liu, Guoxiang Wang, Yan Shen. The shortest expanded allele of the MJD1 gene in a Chinese MJD kindred with autonomic dysfunction. European Neurology, 2004; 52: 107-111.
58. Yanping Wang, Qiang Li, Jiajie Xu, Qingjie Liu, Weiqiu Wang, Yi Lin, Fen Ma, Taiji Chen, Senkai Li and Yan Shen. Mutation analysis of five candidate genes in Chinese patients with hypospadias. European Journal of Human Genetics, 2004, 12: 706-712.
59. Boyu Zhang, Yanbin Jia, Yanbo Yuan, Xin Yu, Qi Xu, Yucun Shen and Yan Shen. No association between polymorphisms in the DDC gene and paranoid schizophrenia in a northern Chinese population. Psychiatric Genetics, 2004; 14:161-163.
60. Yanbin Jia, XinYu, Boyu Zhang, YanboYuan, Qi Xu, Yucun Shen, Yan Shen. No association between polymorphisms in three genes of cytochrome p450 family and paranoid schizophrenia in northern Chinese Han population. European Psychiatry. 2004; 19: 374-376.
61. Yanbin Jia, Xin Yu, Boyu Zhang, Yanbo Yuan, Qi Xu, Yucun Shen, Yan Shen. An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population. European Psychiatry. 2004, 19: 377-379.
62. Sun ZY, Wei J, Xie L, Shen Y, Liu SZ, Ju GZ, Shi JP, Yu YQ, Zhang X, Xu Q, Hemmings GP. The CLDN5 locus may be involved in the vulnerability to schizophrenia. European Psychiatry 2004; 19: 354-357.
63. Deng G, Zhou G, Zhai Y, Li S, Li X, Li Y, Zhang R, Yao Z, Shen Y, Qiang B, Wang Y, He F. Association of estrogen receptor alpha polymorphisms with susceptibility to chronic hepatitis B virus infection. Hepatology. 2004; 40(2): 318-26.
64. Sun X, Zhang H, Wang D, Ma D, Shen Y, Shang Y. DLP, a novel Dim1 family protein implicated in Pre-mRNA splicing and cell cycle progression. Journal of Biological Chemistry, 2004; 279(31): 32839-32847.
65. Deng W, Shi B, he X, Zhaqng Z, Xu j, Li B, Yang J, Ling L, Dai C, Qiang B, Shen Y, Chen R. Evolution and migration history of the Chinese population inferred from Chinese Y-chromosome evidence. Journal of Human Genetetics, 2004, 49(7): 339-348.
66. Qiu-ju Wang, Chun-ye Lu, Ning Li, Shao-qi Rao, Yong-bing Shi, Dong-yi Han, Xia Li, Ju-yang Cao, Li-ming Yu, Qing-zhong Li, Min-xin Guan, Wei-yan Yang, and Yan Shen. Y-linked inheritance of non-syndromic hearing impairment in a large Chinese family. Journal of Medical Genetics, 2004, Jun e-letter.
67. Chinese Schizophrenia Consortium. (Group 1: Qi Xu, Yanbin Jia, Boyu Zhang, Ke Zou, Yubin Tao, Yanping Wang, Boqin Qiang, Guanyun Wu, and Yan Shen; Group 2: Hongkai Ji, Ying Huang, Xiangqing Sun, Liang Ji, and Yanda Li; Group 3: Yanbo Yuan, Liang Shu, Xin Yu, and Yucun Shen, Group 4: Yaqin Yu, Guizhi Ju, Shuzheng Liu, Jiepeng Shi) Association study of SNP combination pattern in dopaminergic pathway with paranoid schizophrenia – A novel strategy for complex disorder. Molecular Psychiatry, 2004, 9(5): 510-521.
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