2013年重要成果(Highlights) 论著(Publications)  Bin Peng, Jun Ni, Craig S. Anderson, Yicheng Zhu, Yongjun Wang, Chuanqiang Pu, Jiang Wu, Jianming Wang, Lixin Zhou, Ming Yao, Jia He, Guangliang Shan, Shan Gao, Weihai Xu and Liying Cui. Implementation of a Structured Guideline-Based Program for the Secondary Prevention of Ischemic Stroke in China. Stroke. 2014;45:515-519  Ting Chen, Delu Song, Guangliang Shan, Ke Wang, Yiwei Wang, Jin Ma, Yong Zhong The Association between Diabetes Mellitus and Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-analysis. PLoS One, 2013 Sep 30;8(9): e76653
Dr. Guangliang Shan, Professor, Department of Epidemiology and Statistics, focusing on survey of national health examination and basic physiological constant, and epidemiological research on cardiovascular risk factors in a cohort of Yi people. Email:firstname.lastname@example.org
Association between insulin receptor gene polymorphism and the metabolic syndrome in Han and Yi Chinese
Chunxiu Wang, Bin Wang, Huijing He, Xiaotong Li, Daying Wei, Jianhua Zhang, Mingju Ma, Li Pan, Tao Yu, Fang Xue, Lin Li, Guangliang Shan
1Department of Evidence-based Medicine, Xuanwu Hospital of Capital Medical University 2Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences 3Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention
Keywords:Metabolic syndrome, Insulin receptor gene, NsiI Polymorphism, Ethnic i Insulin resistance has been a possible underlying pathophysiologic defect inducing the metabolic syndrome (MS). However association studies regarding Insulin receptor gene in different ethnic groups are scarce in literature. Here we conduct an association study between MS and genetic polymorphism of the INSR gene in Yi and Han Chinese. In a cross-sectional study, 3,436 Yi and Han people were investigated. Ethnicity-specific case-control studies were designed, with MS patients diagnosed as cases and non-MS people as controls matched on gender and age. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the genotypes of the exon 8 of the INSR gene. Data were analyzed using one-way analysis of variance, chi-square test, and logistic regression where appropriate. Systolic blood pressure (SBP) was significantly higher in MS patients with the N1N2/N2N2 genotypes than that in those with the N1N1 genotype of both ethnic population (p<0.05). Frequency of the N2 allele was significantly higher in MS patients than that in controls of ethnic Han (p=0.020). Multivariable logistic regression analysis showed that the NsiI polymorphism of the exon 8 of the INSR was an independent predictor for MS in Han people adjusted for total cholesterol, sex, physical activity, educational level, family income, alcohol intake and smoking (OR=2.55, 95% CI: 1.31-4.94, p=0.006). The results indicated that NsiI polymorphism of the INSR gene is associated with SBP in these two different ethnic groups, and significantly associate with MS in Han Chinese. These findings contribute to our better understanding on the genetic basis of MS.
Association between MS and the NsiI RFLP in Han and Yi participants