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2013年单广良课题组年报
[ 作者:基础医学研究所(院)    来源自:本站原创    点击数:21276    更新时间:2014-3-14    文章编辑:wangluo ]

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国民体质与健康参数及标准研究

    单广良,研究员,1998年毕业于中国医学科学院中国协和医科大学,获得流行病学博士学位。一直从事流行病学科研和教学工作。课题组主要研究方向是国民体质与健康调查、国民基本生理参数本底调查和心血管病危险因素研究;在流行病学方法应用方面参与多中心临床研究和全国现场流行病学调查的设计、数据管理和分析。承担了国家十二五科技支撑项目、科技部基础性工作专项、863和国家自然科学基金等课题。
    项目链接主页:http://www.bmicc.cn/web/share/home

 

2013年重要成果(Highlights)
论著(Publications)
[1] Bin Peng, Jun Ni, Craig S. Anderson, Yicheng Zhu, Yongjun Wang, Chuanqiang Pu, Jiang Wu, Jianming Wang, Lixin Zhou, Ming Yao, Jia He, Guangliang Shan, Shan Gao, Weihai Xu and Liying Cui. Implementation of a Structured Guideline-Based Program for the Secondary Prevention of Ischemic Stroke in China. Stroke. 2014;45:515-519
[2] Ting Chen, Delu Song, Guangliang Shan, Ke Wang, Yiwei Wang, Jin Ma, Yong Zhong The Association between Diabetes Mellitus and Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-analysis. PLoS One, 2013 Sep 30;8(9): e76653

 

 

 

 

中国彝族和汉族胰岛素受体基因与代谢综合征的关联

王淳秀, 王斌, 何慧婧, 黎晓彤, 卫大英, 张建华,
马名驹,  潘利, 余涛, 薛芳, 李林, 单广良

    胰岛素抵抗可能是引起代谢综合征(MS)的影响因素之一。然而,有关不同种族胰岛素受体(INSR)基因与代谢综合征的关联研究并不多见。本文探讨了中国彝族和汉族INSR基因多态性与MS的关联。本研究调查彝族和汉族3,436人。按照种族的不同,分别设计两组病例对照研究。分别选取汉族和彝族的MS病例,根据两组病例数随机选择汉族和彝族非MS对照,且与病例在年龄和性别上进行匹配。应用聚合酶链式反应–限制性片段长度多态性(PCR–RFLP)检测INSR基因第8外显子基因型。采用单因素方差分析,卡方检验和logistic回归对数据进行分析。研究结果显示,无论彝族或汉族,MS患者N1N2/N2N2基因型携带者收缩压比N1N1基因型携带者高(p<0.05)。汉族人群INSR基因第8外显子NsiI的基因型和等位基因在病例组和对照组中的频数分布差异有显著性,MS病例组N2等位基因频率显著高于对照组(p=0.020)。多因素logistic回归分析显示,调整总胆固醇、性别、体力活动、教育程度、家庭收入、吸烟和饮酒后,INSR基因第8外显子NsiI多态性是汉族人群MS的独立预测因子(OR=2.55,95%CI: 1.31-4.94,p=0.006)。研究结果表明,INSR基因第8外显子NsiI多态性与彝族和汉族人群的收缩压相关联,且与汉族人群MS关联。本研究对于了解MS发生和发展的遗传基础提供了一定的科学依据。

彝族和汉族NsiI等位基因与代谢综合征的关联

 

Dr. Guangliang Shan, Professor, Department of Epidemiology and Statistics, focusing on survey of national health examination and basic physiological constant, and epidemiological research on cardiovascular risk factors in a cohort of Yi people.
Email:shan@pumc.edu.cn

 

Association between insulin receptor gene polymorphism and the metabolic syndrome in Han and Yi Chinese

Chunxiu Wang, Bin Wang, Huijing He, Xiaotong Li, Daying Wei,
Jianhua Zhang, Mingju Ma, Li Pan, Tao Yu, Fang Xue, Lin Li, Guangliang Shan

1Department of Evidence-based Medicine, Xuanwu Hospital of Capital Medical University
2Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
3Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention

Keywords: Metabolic syndrome, Insulin receptor gene, NsiI Polymorphism, Ethnic i
Insulin resistance has been a possible underlying pathophysiologic defect inducing the metabolic syndrome (MS). However association studies regarding Insulin receptor gene in different ethnic groups are scarce in literature. Here we conduct an association study between MS and genetic polymorphism of the INSR gene in Yi and Han Chinese. In a cross-sectional study, 3,436 Yi and Han people were investigated. Ethnicity-specific case-control studies were designed, with MS patients diagnosed as cases and non-MS people as controls matched on gender and age. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the genotypes of the exon 8 of the INSR gene. Data were analyzed using one-way analysis of variance, chi-square test, and logistic
regression where appropriate. Systolic blood pressure (SBP) was significantly higher in MS patients with the N1N2/N2N2 genotypes than that in those with the N1N1 genotype of both ethnic population (p<0.05). Frequency of the N2 allele was significantly higher in MS patients than that in controls of ethnic Han (p=0.020). Multivariable logistic regression analysis showed that the NsiI polymorphism of the exon 8 of the INSR was an independent predictor for MS in Han people adjusted for total cholesterol, sex, physical activity, educational level, family income, alcohol intake and smoking (OR=2.55, 95% CI: 1.31-4.94, p=0.006). The results indicated that NsiI polymorphism of the INSR gene is associated with SBP in these two different ethnic groups, and significantly associate with MS in Han Chinese. These findings contribute to our better understanding on the genetic basis of MS.

Association between MS and the NsiI RFLP in Han and Yi participants

工作人员简介(Lab Staff)
研究生(Graduate Students)

朱广瑾 研究员
Dr. Guangjin Zhu
Professor
zhugj@pumc.edu.cn

曾宪嘉  副主任技师
Xianjia Zeng
Associate Chief Technician
Zxj28@sohu.com

王丽 研究员
Li Wang,
Professor
Wangli0528@vip.sina.com

潘利  主管技师
Li Pan
Senior Technician
hezipan@yahoo.com.cn

冯逵 助理研究员
Kui Feng,
Research Associate
fengkui@sina.com

研究生(Graduate Students)
王棵,Ke Wang, 2012
董芬,Fen Dong, 2013
王珊, Shan Wang, 2012
龚海英 Haiying Gong, 2013
冯一冰 Yibing Feng
王鑫   Xin Wang

 

 

 

 

 

 

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