信息查询
 时时热点
普通文章 黄波教授研究团队… (12月14日)
普通文章 中国医学科学院牛… (12月13日)
普通文章 中国医学科学院基… (12月13日)
普通文章 2018年公开招聘启… (12月12日)
普通文章 2018年公开招聘启… (12月12日)
普通文章 诚聘优秀人才 (12月6日)热点文章
普通文章 中国医学科学院基… (12月6日)
普通文章 中国医学科学院基… (12月5日)
普通文章 中国医学科学院基… (12月1日)
普通文章 中国医学科学院基… (11月29日)
 最新调查
 没有任何调查
 友情链接
院校直属:
其它部门:
Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer.
[ 作者:科技处    来源自:本站原创    点击数:14971    更新时间:2014-5-20    文章编辑:wangluo ]

减小字体 增大字体

Gong J1, Li J, Wang Y, Liu C, Jia H, Jiang C, Wang Y, Luo M, Zhao H, Dong L, Song W, Wang F, Wang W, Zhang J, Yu J.

Carcinogenesis. 2014 Feb;35(2):497-506.
PMID: 24130168 [PubMed - indexed for MEDLINE]

Abstract
Increasing evidence shows that abnormal microRNAs (miRNAs) expression is involved in tumorigenesis. They might be the novel biomarkers or therapeutic targets in disease treatment. miR-29 family was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in gastric cancer (GC) are not well known. Here, we found that the expression of miR-29 family members was significantly reduced in GC compared with adjacent controls. Among them, miR-29c had the most reduced percentage in GC and was associated with aggressive and progressive phenotypes of GC. We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC. Moreover, the inverse relationship between miR-29 family and their targets was verified in patients and xenograft mice. Finally, reintroduction of miR-29 family significantly inhibited tumor formation of GC cells in the xenograft mice. Take together, our finding characterized the expression properties of miR-29 family, contributed to the function and molecular mechanism of miR-29 family in GC and implied that miR-29 family might be employed as novel prognostic markers and therapeutic targets of GC.

 上一篇文章: The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.
 下一篇文章: Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells.
打印此文】【关闭窗口
CopyRight © 2009 中国医学科学院基础医学研究所&北京协和医学院基础医学院 All Rights Reserved  
地址:北京市东城区东单三条五号   信箱:bgs@ibms.pumc.edu.cn    邮编:100730