信息查询
 时时热点
普通文章 范恩国教授 (9月12日)
普通文章 2017年公开招聘启… (9月5日)热点文章
普通文章 2017年度两优一先… (7月14日)热点文章
普通文章 基础所院党委举办… (7月14日)热点文章
普通文章 中国医学科学院基… (6月20日)热点文章
普通文章 2017年公开招聘启… (6月16日)热点文章
普通文章 中国医学科学院基… (6月15日)热点文章
普通文章 张学教授荣获首届… (5月27日)热点文章
普通文章 科学与奉献精神的… (5月16日)
普通文章 基础所院机关党支… (5月4日)热点文章
 最新调查
 没有任何调查
 友情链接
院校直属:
其它部门:
Specific Phosphorylation of Histone Demethylase KDM3A Determines Target Gene Expression in Response to Heat Shock.
[ 作者:科技处    来源自:本站原创    点击数:14395    更新时间:2014-12-26    文章编辑:wangluo ]

减小字体 增大字体

Cheng MB1, Zhang Y1, Cao CY1, Zhang WL2, Zhang Y1, Shen YF1.

PLoS Biol. 2014 Dec 23;12(12):e1002026
PMID: 25535969

Abstract
Histone lysine (K) residues, which are modified by methyl- and acetyl-transferases, diversely regulate RNA synthesis. Unlike the ubiquitously activating effect of histone K acetylation, the effects of histone K methylation vary with the number of methyl groups added and with the position of these groups in the histone tails. Histone K demethylases (KDMs) counteract the activity of methyl-transferases and remove methyl group(s) fromspecific K residues in histones. KDM3A (also known as JHDM2A or JMJD1A) is an H3K9me2/1 demethylase. KDM3A performs diverse functions via the regulation of its associated genes, which are involved in spermatogenesis, metabolism, and cell differentiation. However, the mechanism by which the activity of KDM3A is regulated is largely unknown. Here, we demonstrated that mitogen- and stress-activated protein kinase 1 (MSK1) specifically phosphorylates KDM3A at Ser264 (p-KDM3A), which is enriched in the regulatory regions of gene loci in the human genome. p-KDM3A directly interacts with and is recruited by the transcription factor Stat1 to activate p-KDM3A target genes under heat shock conditions. The demethylation of H3K9me2 at the Stat1 binding site specifically depends on the co-expression of p-KDM3A in the heat-shocked cells. In contrast to heat shock, IFN-γ treatment does not phosphorylate KDM3A via MSK1, thereby abrogating its downstream effects. To our knowledge, this is the first evidence that a KDM can be modified via phosphorylation to determine its specific binding to target genes in response to thermal stress.

 上一篇文章: Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients.
 下一篇文章: Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.
打印此文】【关闭窗口
CopyRight © 2009 中国医学科学院基础医学研究所&北京协和医学院基础医学院 All Rights Reserved  
地址:北京市东城区东单三条五号   信箱:bgs@ibms.pumc.edu.cn    邮编:100730