信息查询
 时时热点
普通文章 诚聘优秀人才 (11月22日)
普通文章 2018年公开招聘启… (11月21日)
普通文章 中国医学科学院基… (11月14日)
普通文章 铁基纳米材料类酶… (11月8日)
普通文章 2018年公开招聘启… (11月2日)热点文章
普通文章 基础所院党委组织… (11月1日)
普通文章 努力建设我国医学… (11月1日)
普通文章 基础所院党委组织… (11月1日)
普通文章 基础所生化党总支… (11月1日)
普通文章 院校第六督导组到… (11月1日)
 最新调查
 没有任何调查
 友情链接
院校直属:
其它部门:
Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice
[ 作者:基础医学研究所(院)    来源自:本站原创    点击数:16343    更新时间:2015-12-4    文章编辑:wangluo ]

减小字体 增大字体

Sun Y1, Guo F2, Zou Z3, Li C4, Hong X5,6,7, Zhao Y8, Wang C9, Wang H10, Liu H11, Yang P12, Han Z13, Liu K14, Kuba K15, Song B16, Gao J17, Mo Z18, Li D19, Li B20, Li Q21, Zhong N22, Wang C23, Penninger JM24, Jiang C25,26,27

Part Fibre Toxicol. 2015 Mar 7;12:4. PMID:25890286 [PubMed-in process] PMCID: PMC4395934

Abstract
BACKGROUND:
Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases. The molecular mechanisms of nanoparticle toxicity are largely unexplored.
METHODS:
Acute lung injury was induced in wild-type mice and angiotensin-coverting enzyme 2 (ACE2) knockout mice by the intratracheal instillation of cationic polyamidoamine dendrimer (PAMAM) nanoparticles. For rescue experiments, losartan (15 mg/kg in PBS) was injected intraperitoneally 30 min before nanoparticle administration.
RESULTS:
Some PAMAM nanoparticles, but not anionic PAMAM nanoparticles or carbon nanotubes, triggered acute lung failure in mice. Mechanistically, cationic nanoparticles can directly bind ACE2, decrease its activity and down-regulate its expression level in lung tissue, resulting in deregulation of the renin-angiotensin system. Gene inactivation of Ace2 can exacerbate lung injury. Importantly, the administration of losartan, which is an angiotensin II type I receptor antagonist, can ameliorate PAMAM nanoparticle-induced lung injury.
CONCLUSIONS:

Our data provide molecular insight into PAMAM nanoparticle-induced lung injury and suggest potential therapeutic and screening strategies to address the safety of nanomaterials.

 上一篇文章: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation
 下一篇文章: The road to effective tobacco control in China.
打印此文】【关闭窗口
CopyRight © 2009 中国医学科学院基础医学研究所&北京协和医学院基础医学院 All Rights Reserved  
地址:北京市东城区东单三条五号   信箱:bgs@ibms.pumc.edu.cn    邮编:100730