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生物医学工程学系

蒋太交

蒋太交课题组

  

蒋太交,研究员/博士生导师,中国医学科学院生物医学大数据中心主任,国家“杰出青年基金”、中科院“百人计划”及北京协和医学院“协和学者”获得者。

研究方向:计算生物学和系统医学研究

电子邮件:taijiao@ibms.pumc.edu.cn


个人简历

1990-1994  湖南师范大学

1994-1999  中国科学院上海生物化学研究所,获生物化学和分子生物学博士学位

2001-2002  耶鲁大学计算机科学系,获计算机科学硕士学位

1999-2002  在耶鲁大学生物学系Sidney Altman教授实验室从事人核糖核酸P的结构和功能研究

2003-2004  在麻省理工学院Amy Keating教授实验室进行计算结构生物学和系统生物学研究

2004-2015  中国科学院生物物理研究所研究员

2015至今    中国医学科学院基础医学研究所系统医学研究中心、苏州系统医学研究所研究员


研究方向

蒋太交研究员课题组主要从事计算生物学和系统医学方面的研究,研究方向主要包括如下三方面:

(1)发展蛋白质结构预测、基因共进化分析、生物医学数据挖掘以及生物分子网络模建等计算生物学新方法;

(2)结合高通量实验手段,探究包括传染病在内的复杂疾病的分子机理;

(3)运用系统生物学方法,寻找疾病关键分子标志物,为疾病分类、早期诊断和治疗提供线索。


代表性论文

1.    Yousong Peng#, Xiaodan Li#, Hongbo Zhou, Aiping Wu, Libo Dong, Ye Zhang, Rongbao Gao, Hong Bo, Lei Yang, Dayan Wang, Xian Lin, Meilin Jin*, Yuelong Shu* and Taijiao Jiang*. Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses. Scientific Reports. 2017 Mar 6; 7:43566.

2.    Yuanqiang Zou, Zhiqiang Wu, Lizong Deng, Aiping Wu, Fan Wu, Kenli Li, Taijiao Jiang* and Yousong Peng*. cooccurNet: an R package for co-occurrence network construction and analysis. Bioinformatics. 2017 Feb 8. doi: 10.1093/bioinformatics/btx062.

3.    Yousong Peng#, Dayan Wang, Jianhong Wang, Kenli Li, Zhongyang Tan, Yuelong Shu, and Taijiao Jiang*. A universal computational model for predicting antigenic variants of influenza A virus based on conserved antigenic structures. Scientific Reports. 2017 Feb 6; 7:42051.

4.    Chunfeng Li#, Zining Wang#, Yang Cao#, Lulan Wang, Jingyun Jie, Zhigao Chen, Tao Deng, Taijiao Jiang*, Genhong Cheng* and F. Xiao-Feng Qin*. Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System. J Virol. 2017 Feb 14; 91(5). pii: e02282-16.

5.    Yousong Peng#, Lei Yang#, Honglei Li, Yuanqiang Zou, Lizong Deng, Aiping Wu, Xiangjun Du, Dayan Wang, Yuelong Shu* and Taijiao Jiang*. PREDAC-H3: a user-friendly platform for antigenic surveillance of human influenza a (H3N2) virus based on hemagglutinin sequences. Bioinformatics. 2016 Aug 15; 32(16):2526-7.

6.    Lulan Wang#, Stephanie G. Valderramos#, Aiping Wu, Songying Ouyang, Chunfeng Li, Patricia Brasil, Myrna Bonaldo, Thomas Coates, Karin Nielsen-Saines, Taijiao Jiang*, Saba Aliyari*, Genhong Cheng*. From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host & Microbe. 2016 May 11; 19(5):561-5.

7.    Lulan Wang#, Aiping Wu#, Yao E. Wang#, Natalie Quanquin, Chunfeng Li, Jingfeng Wang, Hsiang-Wen Chen, Suyang Liu, Ping Liu, Hong Zhang, F. Xiao-Feng Qin, Taijiao Jiang*, Genhong Cheng*. Functional Genomics Reveals Linkers Critical for Influenza Polymerase. J Virol. 2016 March; 90(6):2938-47.

8.    Mi Liu#, Xiang Zhao#, Sha Hua#, Xiangjun Du, Yousong Peng, Xiyan Li, Yu Lan, Dayan Wang, Aiping Wu*, Yuelong Shu*, Taijiao Jiang*. Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus. Scientific Reports. 2015 Sep 28; 5:14171.

9.    Lizong Deng, Mi Liu, Sha Hua, Yousong Peng, Aiping Wu, F Xiao-Feng Qin*, Genhong Cheng* and Taijiao Jiang*. Network of co-mutations in Ebola virus genome predicts the disease lethality. Cell Research. 2015 Jun; 25(6):753-6.

10.    Chunfeng Li, Aiping Wu, Yousong Peng, Jingfeng Wang, Yang Guo, Zhigao Chen, Hong Zhang, Yongqiang Wang, Jiuhong Dong, Lulan Wang, F. Xiao-Feng Qin, Genhong Cheng*, Tao Deng* &Taijiao Jiang*. Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein. Scientific Reports. 2014 Nov 26; 4:7192.

11.    Lizong Deng, Aiping Wu, Wentao Dai, Tingrui Song, Ya Cui, and Taijiao Jiang*. Exploring protein domain organization by recognition of secondary structure packing interfaces. Bioinformatics. 2014 Sep 1; 30(17):2440-6.

12.    Aiping Wu, Chunhu Su, Dayan Wang, Yousong Peng, Mi Liu, Sha Hua, Tianxian Li, George F. Gao, Hong Tang, Jianzhu Chen, Xiufan Liu, Yuelong Shu, Daxin Peng*, and Taijiao Jiang*. Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China. Cell Host & Microbe. 2013 Oct 16; 14(4):446-52.

13.    Chunfeng Li, Qi Ba, Aiping Wu, Hong Zhang, Tao Deng*, Taijiao Jiang*. A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly. FEBS J. 2013 Feb; 280(4):1139-49.

14.    Yongqiang Wang, Xinlei Zhang, Hong Zhang, Yi Lu, Haolong Huang, Xiaoxi Dong, Jinan Chen, Jiuhong Dong, Xiao Yang, Haiying Hang, Taijiao Jiang*. Coiled-coil networking shapes cell molecular machinery. Mol Biol Cell. 2012 Oct 1; 23(19):3911-22.

15.    Xiangjun Du, Libo Dong, Yu Lan, Yousong Peng, Aiping Wu, Ye Zhang, Weijuan Huang, Dayan Wang, Min Wang, Yuanji Guo, Yuelong Shu* & Taijiao Jiang*. Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation. Nature Communications, 28 Feb 2012; 3:709.

16.    Zhichao Miao, Yang Cao, Taijiao Jiang*. RASP: Rapid modeling of protein side-chain conformations. Bioinformatics. 2011 Nov 15; 27(22):3117-22.

17.    Liqing Tian, Aiping Wu, Yang Cao, Xiaoxi Dong, Yun Hu, Taijiao Jiang*. NCACO-score: An effective main-chain dependent scoring function for structure modeling. BMC Bioinformatics, 2011 May 26; 12: 208.

18.    Yang Cao, Lin Song, Zhichao Miao, Yun Hu, Liqing Tian, Taijiao Jiang*. Improved side-chain modeling by coupling clash-detection guided iterative search with rotamer relaxation. Bioinformatics, 2011 Jan 6; 27 (6):785-90.

19.    Hong Zhang, Taijiao Jiang*. Synthetic circuits, devices and modules. Protein Cell, 2010 Nov; 1(11):974-8.

20.    Aiping Wu, Yousong Peng, Xiangjun Du, Yuelong Shu, Taijiao Jiang*. Correlation of Influenza Virus Excess Mortality with Antigenic Variation: Application to Rapid Estimation of Influenza Mortality Burden. PLoS Comput Biol, 2010 Aug 12; 6(8):e1000882.

21.    Hong Zhang, Jinan Chen, Yongqiang Wang, Lin Peng, Xiaoxi Dong, Yi Lu, Amy E. Keating*, Taijiao Jiang*. A computationally guided protein screen uncovers coiled-coil interactions involved in vesicular transport. J Mol Biol, 2009 Sep 11; 392(1):228-41.

22.    Xiangjun Du, Zhuo Wang, Aiping Wu, Lin Song, Yang Cao, Haiying Hang, and Taijiao Jiang*. Networks of genomic co-occurrence capture characteristics of human influenza A (H3N2) evolution.Genome Res, 2008 Jan 1; 18(1):178-87.