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生物化学与分子生物学系

蒋澄宇



导师简介:

  北京协和医学院基础学院教授。1988年毕业于中国科学技术大学生物系,获理学学士学位,1997年毕业于美国布朗大学分子生物,细胞生物,和生物化学系和布朗医学院病理与实验室医药系,获博士学位。随后在美国哈佛医学院遗传系与麻省总医院分子生物学系做博士后工作。2003年回国在北京协和医学院生物化学与分子生物学系工作。先后获教育部长江学者特聘教授,国家杰出青年基金获得者,卫生部有突出贡献中青年专家,人事部百千万人才工程国家级人选,中国青年女科学家等荣誉称号,是973研究计划呼吸系统疾病领域唯一项目的首席科学家。

 

实验室简介:

实验室自从2003年建立以来,长期致力于呼吸系统肺损伤相关疾病的致病机理的研究和药物研发。阐述了SARS冠状病毒,禽流感H5N1,甲流,和艾博拉等病毒和微纳米细颗粒物引发致病的分子机理。研究成果发表在《自然》、《自然·医学》、《自然·通讯》、和《科学·信号》等杂志上。曾获得中, , 欧盟等国专利,并曾独家转让给世界排名前五名的制药公司和欧盟的生物技术公司。目前课题组有教授1名,副研究员1名,助理研究员1名,高级技师1名,博士后2名,技术员2名,研究生10余名。

 

代表性论文:

1.             Du, J., Liang, Z., Xu, J., Zhao, Y., Li, X., Zhang, Y., ... & Jiang, C. (2017). Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7. Science China Life Sciences, 1-12.

2.         Zhang, Y.L., Tang, J., Yang, N., Liu, Q., Zhang, Q.C., Zhang, Y.X., Li, N., Zhao, Y., Li, S.W., Liu, S., Zhou, H.D., Li, X., Tian, M.Y., Deng, J.J., Xie, P., Sun, Y., Lu, H.J., Zhang, M.Q., Jin, N.Y., Jiang, C., FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN, Journal of Immunology, 2016

3.         Ju X., Yan Y., Liu Q., Li N., Sheng M., Zhang L., Li X., Liang Z., Huang F., Liu K., Zhao Y., Zhang Y., Zou Z., Du J., Zhong Y., Zhou H., Yang P., Lu H., Tian M., Li D., Zhang J., Jin N., Jiang C. Neuraminidase of influenza A virus binds lysosome-associated membrane proteins directly and induces lysosome rupture, Journal of Virology, 2015

4.             Zou, Z, Yan, Y, Shu, Y, Gao, R, Sun, Y, Li, X, Ju, X, Liang, Z, Liu, Q, Zhao, Y, Guo, F, Bai, T, Han, Z, Zhu, J, Zhou, H, Huang, F, Li, C, Lu, H, Li, N, Li, D, Jin, N, Penninger*, JM, Jiang*, C (2014) Angiotensin-Converting Enzyme 2 protects from lethal Avian Influenca A H5N1 Infections Nat Commun 10.1038/ncomms4594.

5.             Huang, F, Guo, J, Zou, Z, Liu, J, Cao, B, Zhang, S, Li, H, Wang, W, Sheng, M, Liu, S, Pan, J, Bao, C, Zeng, M, Xiao, H, Qian, G, Hu, X, Chen, Y, Chen, Y, Zhao, Y, Liu, Q, Zhou, H, Zhu, J, Gao, H, Yang, S, Liu X, Zheng, S, Yang, J, Diao, H, Cao, H, Wu, Y, Zhao, M, Tan, S, Guo, D, Zhao, X, Ye,Y, Wu, W, Xu, Y, Penninger, JM, Li, D, Gao*, G, Jiang*, C, Li*, L (2014) Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun 10.1038/ncomms4595

6.             Xu*, C, Ju, X, Song, D, Huang, F, Tang D, Zou, Z, Zhang, C, Joshi, T, Jia, L, Xu, W, Xu, K, Wang, Q, Xiong, Y, Guo, Z, Chen, X, Huang, F, Xu, J, Zhong, Y, Zhu, Y, Peg, Y, Wang, L, Zhang, X, Jiang, R, Li, D, Jiang, T, Xu, D, Jiang*, C (2014) An association analysis between psychophysical characteristics and genome-wide gene expression changes in human adaption to the extreme climate at the Antarctic Dome Argus Mol Psychiatry 10.1038/mp.2014.72.

7.             Sheng, M, Zhong, Y, Chen, Y, Du, J, Ju, X, Zhao, C, Zhang, G, Zhang, L, Liu, K, Yang, N, Xie, P, Li, D, Zhang*, M.Q, Jiang*, C (2014) Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro Sci China Life Sci. 57(10):959-72

8.             Wang, W, Yang, P, Zhong, Y, Zhao, Z, Xing, L, Zhao, Y, Zou, Z, Zhang, Y, Li, C, Li, T, Wang, C, Wang, Z, Yu, X, Cao, B, Gao, X, Penninger, J, Wang*, X, Jiang*, C (2013) Monoclonal Antibody Against CXCL-10/ IP-10 Ameliorated Influenza A (H1N1) Induced Acute Lung Injury. Cell Res. 23:577-580

9.             Yan, Y, Zou, Z, Sun, Y, Li, X, Xu, K, Wei, Y, Jin*, N, Jiang*, C (2013) Anti-Malaria Drug Chloroquine is Highly Effective in Treating Avian Influenza A H5N1 Virus Infection in an Animal Model Cell Res. 23:300-302

10.         Zhang, Y, Deng, J, Zhang, Y, Guo, F, Li, C, Zou, Z, Xi, W, Tang, J, Sun, Y, Yang, P, Han, Z, Jiang*, C (2013) Functionalized Single-Walled Carbon Nanotubes Cause Reversible Acute Lung Injury and Induce Fibrosis in Mice J. Mol. Med. 91:117-128

11.      Sun, Y, Li, C, Shu, Y, Wang, H, Ju, X, Zou, Z,Wang, H, Rao, S, Guo, F, Liu, H, Nan, W, Zhao, Y, Yan, Y, Tang, J, Zhao, C, Yang, P, Liu, K, Wang, S, Lu, H, Li, X, Tan, L, Gao, R, Song, J, Gao, X, Tan, X, Qin, Y, Xu, K, Li D, Jin*, N, Jiang*, C (2012) Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection. Science Signaling (Cover Story) 5 (212) ra16

12.      Yang, N, Ma, P, Lang, J, Zhang, Y, Deng, J, Ju, X, Zhang, G, Jiang*, C (2012) Phosphatidylinositol 4-Kinase III_ Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry. J. Biol. Chem. 287(11) 8457-8467

13.      Li, C, Yang, P, Sun, Y, Li, T, Wang, C, Wang, Z, Zou, Z, Yan, Y, Wang, W, Wang, C, Chen, Z, Xing, L, Tang, C, Ju, X, Guo, F, Deng, J, Zhao, Y, Yang, P, Tang, J, Wang, H, Zhao, Z, Yin, Z, Cao, B, Wang*, X, Jiang*, C (2012) IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus. Cell Res. 22:528-538