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病理生理学系

王婧

王婧 博士生导师

 

主要学习、工作经历:

2003年毕业于北京大学医学部基础医学系,获学士学位。 2009年在美国罗彻斯特大学获得病理学博士学位。2009-2013年在美国哈佛大学医学院从事博士后研究,先后晋升为讲师,研究助理教授。2013年入选国家中组部“青年千人”计划,做为2014年基础所院“引进人才”,任病理生理系研究员。主要从事重大心脑血管疾病的发病机制的研究工作。

 

研究方向:

1.    炎症与心血管疾病

2.    非编码RNA与心血管疾病

3.    干细胞与心血管疾病

 

课题组成员:

1.     工作人员: 李瑶 技师;赵红梅 助理研究员;闫莉 讲师

2.     直博生:    高冉(毕业于天津医科大学);舒婷(毕业于北京大学医学部);                      葛伟鹏(毕业于大连医科大学)

3.     硕士研究生:张唯(毕业于中国医科大学);宋小敏(毕业于华中农业大学);               邹璇(毕业于湖南大学);郭文钧(毕业于辽宁师范大学)

 

联系方式

电话:69156477

Email: wangjinglab@hotmail.com

 

主要获奖情况:

2016       优秀青年科学基金

2013       第五批青年千人计划入选者

2012       美国哈佛大学医学院优秀华人科学家奖

2011       美国心血管协会优秀青年科学家奖

 

代表论文:

1.     Wang Z, Ni L, Wang J#, Lu C, Ren M, Han W, Liu C#. The protective effect of melatonin on smoke-induced vascular injury in rats and humans: a randomized controlled trial. J Pineal Res. 2016 Mar;60(2):217-27.

2.     Guo X, Yuan S, Liu Y, Zeng Y, Xie H, Liu Z, Zhang S, Fang Q, Wang J#, Shen Z#. Serum IgE levels are associated with coronary artery disease severity. Atherosclerosis. 2016 May 12. pii: S0021-9150(16)30197-6.

3.     Lv BJ, Lindholt J, Cheng X, Wang J#, Shi GP#. Plasma cathepsin S and cystatin C levels and risk of abdominal aortic aneurysm: a randomized population –based study. Plos One,  2012,7(7): e41813. Jul 23

4.     Wang J*, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015 Jul;21(7):820-6. doi: 10.1038/nm.3890. Epub 2015 Jun 22.

5.     Wang J*, Cheng X, Xiang M, Kinnunen M, Wang J, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjoberg S , Sukhova G, Liao YH, Conrad D, Yu LY, Kawakami T, Kovanen P, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice. J Clin Invest., 2011 Sep;121(9):3564-77

6.     Wang J*, Sjöberg S, Lindholt J, Xia M, Chen H, Xiong N, Sukhova G, Libby P, Shi GP. IgE promotes abdominal aortic aneurysm formation in Apoe–/– mice by regulating macrophage and T cell activation. EMBO Mol Med., 2014 Jun 24;6(7):952-69

7.     Cheng X*, Wang J*, Xia N, Yan XX, Tang TT, Chen H, Zhang HJ, Liu J, Kong W, Sjöberg S, Folco E, Libby P, Liao YH, Shi GP.  A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med., 2012, Oct;4(10):1112-25

8.     Wang J*, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC Phosphorylation of G Protein-Coupled Receptor Kinase 2-Interacting Protein 1 Tyrosine 392 Is Required for Phospholipase C-{gamma} Activation and Podosome Formation in Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol., 2010 Oct;30(10):1976-82

9.     Wang J*, Taba Y, Pang J, Yin G, Yan C, Berk BC. GIT1 mediates VEGF-induced endothelial cell podosome formation-critic role for PLCγ. Arterioscler Thromb Vasc Biol., 2009 Feb;29(2):202-8

10.  Wang J*, Pan S, Berk BC. Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arterioscler Thromb Vasc Biol., 2007 Jun;27(6):1283-8

11.  Chen H*, Wang J*,Sjoberg S, Libby P, Shi GP. E64d Deteriorates Post-Myocardial Infarction Left Ventricular Remodeling by Inhibiting Cathepsin S-Mediated Fibroblast Trans-Differentiation. Cardiovasc Res. 2013 Oct 1;100(1):84-94

12.  Wang J*, Sjöberg S, Tang TT, Oörni K, Wu W, Liu C, Secco B, Tia V, Sukhova GK, Fernandes C, Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta-molecular basis of disease. 2014 Nov;1842(11):2174-83

13.  Wang J*, Sun J, Sjöberg S, Tia V, Secco B, Chen H, Shi GP. Pharmaceutical stabilization of mast cells attenuate experimental atherogenesis in low-density lipoprotein receptor-deficient mice Atherosclerosis, 2013, Aug;229(2):304-9.

14.  Wang J*, Shi GP. Mast cell stabilization: Novel medication for obesity and diabetes. Diabetes/Metabolism Research and Review, 2011 Nov;27(8):919-24

15.  Wang J*, Sukhova GK, Liu J, Ozaki K, Lesner A, Libby P, Kovanen PT, Shi GP. Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice. J Vasc Surg. 2014 Jul 16. pii: S0741-5214(14)01115

16.  Chen H*; Wang J*; Shi GP “Role of Lysosomal Cathepsins in Post-Myocardial Infarction Remodeling “ North American Journal Medicine & Science, 2011 Oct, 4 (4): 173-178

17.  Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC. G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation, 2009 Mar 24;119(11):1524-32

18.  Liao YH, Xia N, Zhou SF, Tang TT, Yan XX, Lv BJ, Nie SF, Wang J, Iwakura Y, Xiao H, Yuan J, Jevallee H, Wei F, Shi GP, Cheng X. Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. Journal of the American College of Cardiology, 2012 Jan 24;59(4):420-9

19.  Lv BJ, Lindholt JS, Wang J, Cheng X, Shi GP. Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study. Atherosclerosis. 2013 Sep;230(1):100-5.

20.  Pang J, Xu X, Wang X, Majumder S, Wang J, Korshunov VA, Berk BC. G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration. Arterioscler Thromb Vasc Biol. 2013 May;33(5):999-1005