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人体解剖与组织胚胎学系

马超

负责人:马超1999年获协和医科大学八年制医学博士学位,同年进入协和医院外科任住院医师,2000年赴美国耶鲁大学医学院麻醉系进行博士后研究,2003年起任Associate Research Scientist2008年起任耶鲁大学医学院助理教授。201112月回医科院基础所工作,任人体解剖与组织胚胎学系主任、教授、博士生导师。获得协和学者荣誉称号、中国青年解剖科学家、院校优秀教师、北京脑科学与类脑中心北脑学者、北京市及全国高等教育教学成果奖等。

主要研究方向:

1. 慢性痛与痒的神经机制 Neural Mechanisms of Chronic Pain & Itch

        慢性痛是我国乃至全世界范围内严重影响人们健康生活质量的主要问题之一。在医科院基础所原谢益宽教授实验室的基础上,我们已经建立起了一个神经生物学研究实验室和科研梯队,以神经电生理、药理学、影像学、免疫组化和动物行为学为主要手段,以背根神经节在体和离体记录平台为技术特色,重点研究慢性痛的免疫相关机制以及外周感觉神经元的异位放电机理。

        在此基础上,我还与耶鲁大学医学院、协和医院等科研和临床机构开展积极合作,将研究范围推广到慢性痛与瘙痒患者的病理改变和治疗。痒觉的研究在世界范围内仍处于起步阶段,而其临床价值越来越受到人们的重视。运用类似的方法和思路,痒觉及瘙痒症的基础与临床研究可以与慢性痛的研究同步开展。

2. 国家发育和功能人脑组织资源库建设与研究项目: National Human Brain bank for Development and Function

        国家发育和功能人脑组织库是在北京协和医学院遗体捐献接收站基础上建立的以收集保藏人脑组织、服务国内神经科学相关研究为目的的公益机构。20196月正式纳入科技部国家科技资源共享服务平台:国家发育和功能人脑组织资源库。 截至202010月,已接受并保存了319例全脑组织样本。以人脑组织为基础,开展人脑库标准化建设、人脑衰老与痴呆相关的神经病理及其相关机制和多种组学研究。与北京协和医院合作建立了基于人体组织器官库的老年人群前瞻性队列,完善捐献者生前神经系统检查(包括MRI等影像学检查)及认知评估,结合去世后神经病理评估,建立信息完善的组织样本资源平台。已为本院校及国内其他单位的多个研究课题组提供了宝贵的人脑组织样本,有力的支持了中国的脑科学与脑疾病研究。

        目前该研究项目已经获得中国医学科学院人体组织器官资源库建设项目支持。

课题组成员:

现有教授2人(马超,谢益宽),助理研究员3人,主管技师1人,在读博士研究生1人,硕士研究生4人,八年制医学生科研训练3人,大学生创新基金”5

热忱欢迎有志于神经生物学研究的老师和同学加入!

联系方式:Email: mcpumc@163.com ,电话: 010-69156469Lab

课题组网页:http://anatomy.sbm.pumc.edu.cn/viewname.asp?/940.html

 

课题组及人体解剖与组织胚胎学系师生合影



5年代表性论著 *: 通讯作者)

 [科研论文]

  1. 1.Liu P, Yang Q, Yu N, Cao Y, Wang X, Wang Z, Qiu WY, Ma C*. Phenylalanine Metabolism Is Dysregulated in Human Hippocampus with Alzheimer's Disease Related Pathological Changes. J Alzheimers Dis83(2):609-622, 2021.
  2. 2.Guo Z, Shao C, Zhang Y, Qiu W, Li W, Zhu W, Yang Q, Huang Y, Pan L, Dong Y,Sun H, Xiao X, Sun W*, Ma C*, Zhang L*. A Global Multiregional Proteomic Map of the Human Cerebral Cortex. Genomics, Proteomics & Bioinformatics[Accepted June 24, 2021]
  3. 3.Cui H, Su W, Cao Y, Ma C*,Qiu W*. The altered anatomical distribution of ACE2 in the brain with Alzheimer's Disease pathology. Front Cell Dev Biol2021.
  4. 4.Jia Y, Wang X, Chen Y, Qiu W, Ge W*, MaC*. Proteomic and Transcriptomic Analyses Reveal Pathological Changes in the Entorhinal Cortex Region that Correlate Well with Dysregulation of Ion Transport in Patients with Alzheimer’s Disease. Mol Neurobiol58:4007–4027, 2021.
  5. 5.Cui H, Su W, Cao Y, Ma L, Xu G, Mou W, Zhang Hanlin, Yu Jiawen, Ma C*, ZhangX*,Huang Y. Lack of spinal Neuropeptide Y is involved in mechanical itch in aged mice. Font Aging Neurosci2021.
  6. 6.SuW, Cui H, Wu D, Yu J, Ma L, Zhang X, Huang Y*, Ma C*. Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis. J Neuroinflammation 18:65, 2021
  7. 7.Wang T, Tao J, Fang Y, Ma C*.The Role of Pruriceptors in Enhancing Sensitivity to Pruritogens in a Murine Chronic Compression Model of Dorsal Root Ganglion. Molecular Brain14:15, 2021
  8. 8.Cong C, Zhang W, Qian X, Qiu W*, Ma C*. Significant Overlap of α-Synuclein, Amyloid-β and Phospho-Tau Pathologies in Neuropathological Diagnosis of Lewy-related Pathology: Evidence from China Human Brain Bank. J Alzheimers Dis80:447-458, 2021
  9. 9.Wang T, Zhang Y, Chen W, Tao J, Xue Q, Ge W, Dou W*,Ma C*.Proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy: effects of topical treatment.Biomedicine & Pharmacotherapy133:110844, 2021
  10. 10.Fang Y, Han S, Li X, Xie Y, Zhu B, Gao X*, Ma C*. Cutaneous Hypersensitivity as an Indicator of Visceral Inflammation via C-Nociceptor’s Axon Bifurcation. Neurosci Bull37:45-54, 2021
  11. 11.Liu F, Shen X, Su S, Cui H, Fang Y Wang T, Zhang L,Huang Y, Ma C*.FcγRI-coupled signaling in peripheral nociceptors mediates joint pain in a rat model of rheumatoid arthritis.ArthritisRheumatol72(10):1668-78,2020
  12. 12.He Y, .L, Fang Y, Dan Z, Shen Y, Tan G, Huang Y*, Ma C*. Electrospun PLGA Nanomembrane: A Novel Formulation of Extended- Release Bupivacaine Delivery Reducing Postoperative Pain. Materials & Design 193:108768, 2020
  13. 13.Liu Y, Liu H, Li C, Ma C*, Ge W*. Proteome Profiling of Lung Tissues in Chronic Obstructive Pulmonary Disease (COPD): Platelet and Macrophage Dysfunction Contribute to the Pathogenesis of COPD. Int J Chron Obstruct Pulmon Dis 15:973-9802020.
  14. 14.Zhang W, ZhangQ, Yang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*,Ma C*.Contribution of Alzheimer’s Disease Neuropathologic Change to the Cognitive Dysfunction in Human Brains with Lewy Body-Related Pathology. Neurobio Aging91:56-65, 2020.
  15. 15.Zhu J, Chen ZY, Fang Y, Duan W, Xie Y, Ma C*. Injury of the Muscular Nerve but not Cutaneous Nerve Drives Acute Neuropathic Pain. Neurosci Bull36:453–462,2020. [Cover Article]
  16. 16.Fang Y, Zhu J, Duan W, Xie Y, Ma C*. Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain. Neurosci Bull36:1-10, 2019.
  17. 17.Chen Z, Wang T, Fang Y, Luo D, Anderson M, Huang Q, He S, Song X, Cui H, Dong X, Xie Y, Guan Y*, Ma C*. Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy. Sci Rep9:7651, 2019.
  18. 18.Jiang H, Cui H, Wang T, Shimada SG, Sun R, Tan Z, Ma C*, LaMotte RH*. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain BehavImmun80:464–473, 2019.
  19. 19.Wang X, Xia W, Li K, Zhang Y, Ge W*, Ma C*.Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse.J Neurol Sci 399:125-139, 2019.
  20. 20.Xiong F, Ge W*, Ma C*. Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association15(3):429–440,2019. doi: 10.1016/j.jalz.2018.10.006.
  21. 21.Yang Q, Chen K, Zhang H, Zhang W, Gong C, Zhang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*,Ma C*. Correlations between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease among Han Chinese. Neurosci Bull35(2):193-204, 2019
  22. 22.Zhang F, Wei J, Li X, Ma C*, Gao Y*. Early candidate urine biomarkers for detecting Alzheimer's disease before beta amyloid plaque deposition in an APP (swe)/PSEN1dE9 transgenic mouse model. J Alzheimers Dis66:613–637, 2018.
  23. 23.Zhang H, Chen K, Wang N, Zhang D, Yang Q, Zhang Q, Liu P, Wang M, Gong C, Hong X, Qiu W, Qian X, Chen Y*, Ma C*. Analysis of Brain Donors' Demographic and Medical Characteristics to Facilitate the Construction of a Human Brain Bank in China. J Alzheimers Dis66:1245–1254, 2018.
  24. 24.Xu Z, Wang T, Guo X, Li Y, Hu Y, Ma C*, Wang J*. The relationship of serum antigen-specific and total immunoglobulin E with adult cardiovascular diseases. Int J Med Sci 15 (11):1098-1104, 2018.doi: 10.7150/ijms.25857.
  25. 25.Wang Z, Liu F, Wei M, Qiu Y, Ma C*, Shen L*, Huang Y*.Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway. J Neuroinflammation 15(1):179, 2018.
  26. 26.Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C*, LaMotte RH*. Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.Neurosci Lett668:154–158,2018.
  27. 27.Li J, Zhang W, Wang X, Yuan T, Liu P, Wang T, Shen L, Huang Y, Li N, You H, Xiao T, Feng F*, Ma C*. Functional magnetic resonance imaging reveals differences in brain activation in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy. PLoS One13(1): e0190699, 2018.
  28. 28.Qiu W, Yang Q, Zhang W, Wang N, Zhang D, Huang Y, Ma C*. The Correlations Between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and Alzheimer’s Disease. Curr Alz Res15:1-12, 2018.

[综述和论著]

  1. 29.Li HY*, Wang F, Chen M, Zheng ZJ, Yin YJ, Hu J, Li H, Sammer A, Feigl G, Maurer N, Ma C*, Ji FS*. An acupoint-originated human interstitial fluid circulatory network. Chin Med J, 2021.
  2. 30.Tang K, Wang M, Zhang H, Zhang Q, Yang Q, Chen K, Wang N, Zhang D, Qiu W*,Ma C*. The top 100 most-cited articles citing human brain banking from 1970 to 2020: a bibliometric analysis. Cell and Tissue Banking, 21:685–697, 2020.
  3. 31.SuS, Cui H, WangT, ShenX. Ma C*. Pain: A Potential New Label of COVID-19.Brain Behav Immun87:159-160, 2020.
  4. 32.He Y, Qin L, Huang Y, Ma C*. Advances of Nano-Structured Extended-Release Local Anesthetics. Nanoscale Res Lett 15:13, 2020.
  5. 33.Vornholt E, Luo D, Qiu W, McMichael GO, Liu Y, Gillespie N, Ma C*, Vladimirov VI*.Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations. Neurosci Biobehav Rev102:195-207, 2019.
  6. 34.Ma C*, Bao AM, Yan XX, Swaab DF. Progress in Human Brain Banking in China.Neurosci Bull.35(2):179-182, 2019.
  7. 35.Qiu W, Zhang H, Bao A, Zhu K, Huang Y, Yan X, Zhang J, Zhong C, Shen Y, Zhou J, Zheng X, Zhang L, Shu Y, Tang B, Zhang Z, Wang G, Zhou R, Sun B, Gong C, Duan S, Ma C*. Standardized Operational Protocol for Human Brain Banking in China.Neurosci Bull.35(2):270-276, 2019.