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病理生理学系

杨先达

杨先达课题组目前有助理研究员一名,主任技师一名,研究生和进修生多名;有两个主要的科研方向:纳米技术的医学应用和肿瘤靶向分子的开发研究。

杨先达教授为协和医科大学医学博士、美国纽约州立大学理学博士和美国内科医师,既往曾任美国斯坦福大学博士后研究员、美国罗氏药厂科学家、美国法玛西药厂亚洲区医学总监、美国硅谷圣何西医学中心主治医师等职,具备基础科研、临床研究和临床医疗方面的丰富经验。在基础科研方面,成果曾发表于自然杂志(Nature)等国际学术刊物;在临床研究方面,曾设计和参与多项呈交美国FDA审批的国际性临床药物试验;在临床医疗方面,具美国行医执照和多年临床经验。回国后将碳纳米技术应用于抗肿瘤免疫疗法并取得了国际领先的科研成果,在肿瘤靶向分子的研发方面也有扎实的进展。

近年发表论文:

[1] Sun Zhao,Liu Zhe, Meng Jie, Meng Jie,Duan Jinhong,Xie Sishen,Lu Xin,Zhu Zhaohui,Wang Chen,Shuchang,Xu Haiyan,Yang Xian-Da

Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes

In Vitro(2011) Plosone, 6(6), pp 21073-21081

 

[2] Chenchen Yu,Yan Hu,Jinhong Duan, Xianda Yang

Novel Aptamer-Nanoparticle Bioconjugates Enhances Delivery of

Anticancer Drug to MUC1-Positive Cancer Cells In Vitro(2011) Plosone,

6(9), pp 24077-24085

 

[3]  Liu Zhe,Jinhong Duan,YongMei Song,Jie Ma,Fengda Wang,Xin Lu, Xian-DaYang

Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2-positive Breast Cancer Cells in Vitro.J Transl Med, (2012) Jul 20; 10, 148-158

 

[4] Yan Hu, Jinhong Duan, Qimin Zhan,FengDan Wang,Xin Lu, Xian-Da Yang

Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer

 cells in vitro.Plosone (2012)7231970-31980

 

[5] Liang Zhang, Sun Zhao,Jinhong Duan,Ning Gu,Haiyan Xu,Xian-da Yang

Enhancement of DC-mediated anti-leukemic immunity in vitro by WT1

antigen and CpG co-encapsulated in PLGA microparticles  Protein &

Cell, (2013)13(3916), pp 1-3,

 

[6] Beibei Cao, Yan Hu, Jinhong Duan, Jie Ma, Danke Xu, Xian-Da Yang

Selection of a Novel DNA Aptamer for Assay of Intracellular

Interferon-Gamma (2014) PLoS ONE 9(5): e98214.

 

[7] Wei Wang, Zhongjun Li, Jinhong Duan, Chen Wang, Ying Fang, and Xian-Da Yang

    In vitro enhancement of dendritic cell-mediated anti-glioma immune

response by graphene oxide Nanoscale Research Letters 2014, 9:311 

 

[8] Lianyuan Yu, Yan Hu, Jinhong Duan, and Xian-Da Yang

 A Novel Approach of Targeted Immunotherapy against Adenocarcinoma Cells

 with Nanoparticles Modified by CD16 and MUC1 Aptamers2015

Journal of Nanomaterials ( Article ID 316968 p1-10 Hindawi Publishing Corporation)

 

[9]Hu YanJ DuanB CaoL ZhangX LuXian-Da Yang

Selection of a Novel DNA Thioaptamer against HER2 Structure

Clinical & translational oncology (2015), 17(8):págs. 647-656

 

 [10]Guo FangqinY HuL YuX DengJ MengXian-Da Yang

Enhancement of Thermal Damage to AdenocarcinomaCells by Iron

Nanoparticles Modified with MUC1 Aptamer

Joural of Nanoscience and nanotechnology (2016)16(3):2246-2253

 

[11] Dai Bindong Hu yan Duan Jinhong, Yang xianda

Aptamer-guided DNA tetrahedron as a novel targeted drug delivery system

for muc1-expressing breast cancer cells in vitro  Oncotarget (2016) Jun 21;7(25):38257-38269

 

[12]Meng Jie, Fangqin Guo, Haiyan Xu, Wei Liang, Chen Wang, Xian-Da Yang

Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in

Liposomes for Drug Resistance Reversal in Breast Cancer Cells in

Vivo (2016) 6:1-11 

 

近年获得专利:

1. HER2蛋白核酸适配子、复合体、组合物及其用途(专利号:201210044833.9)

2. MUC1蛋白核酸适配子、复合体、组合物及其用途(专利号:201110425169.8)