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生物物理及结构生物学系

王晨轩

简介

王晨轩,中国医学科学院基础医学研究所/北京协和医学院课题组长。2008年毕业于兰州大学国家理科化学基地班,获学士学位。2008年至2013年,国家纳米科学中心研究生,中国科学院与清华大学化学系联合培养,物理化学专业,2013年获清华大学博士学位。2013年至2018年在美国威斯康辛大学-麦迪逊分校化学系及化学与生物工程系从事博士后研究。

长期从事扫描隧道显微术与原子力探针显微术的应用研究;纳米尺度上物质表面的物理和化学现象研究;疾病相关多肽的组装结构及其调控的单分子水平研究。目前主要的研究兴趣是界面生物物理与结构生物学。

 

研究方向

        1. 基于扫描探针显微技术的单分子结构生物学与生物物理研究

        2. 合成肽调控蛋白-蛋白界面结构与分子间相互作用

        3. 材料界面多肽/蛋白单分子水平结构生物学研究

        4. 界面生物物理、物理化学现象的宏观生物学效应

 

发表论文                  

2017 Publications

Chenxuan Wang, C. Derek Ma, Hongseung Yeon, Xiaoguang Wang, Samuel H. Gellman, Nicholas L. Abbott, “Nonadditive interactions mediated by water at chemically heterogeneous surfaces: non-ionic polar groups and hydrophobic interactions”, J. Am. Chem. Soc., 2017, 139, 18536–18544.

 

Hongseung Yeon, Chenxuan Wang, Reid C. Van Lehn, Nicholas L. Abbott, “Influence of order within nonpolar monolayers on hydrophobic interactions”, Langmuir, 2017, 33, 4628-4637.

 

Timothy J. Smith, Chenxuan Wang, Nicholas L. Abbott, “Redox-triggered mixing and demixing of surfactants within assemblies formed in solution and at surfaces”, J. Colloid Interface Sci., 2017, 502, 122-133.

 

Aihua Yang, Chenxuan Wang, Baomin Song, Wendi Zhang, Yuanyuan Guo, Rong Yang, Guangjun Nie, Yanlian Yang, Chen Wang, “Attenuation of b-amyloid toxicity in vitro and in vivo by accelerated aggregation”, Neurosci. Bull., 2017, 33, 405-412.

 

2016 Publications

C. Derek Ma, Claribel Acevedo-Vélez, Chenxuan Wang, Samuel H. Gellman, Nicholas L. Abbott, “Interaction of the hydrophobic tip of an atomic force microscope with oligopeptides immobilized using short and long tethers”, Langmuir, 2016, 32, 2985–2995.

Juan Liu, Tuo Wei, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowei Ma, Xing-Jie Liang, “Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance”, Biomaterials, 2016, 91, 44-56.

 

2015 Publications

C. Derek Ma, Chenxuan Wang, Claribel Acevedo-Vélez, Samuel H. Gellman, Nicholas L. Abbott, “Modulation of hydrophobic interactions by proximally immobilized ions”, Nature, 2015, 517, 347-350.

Yanmei Wang*, Chenxuan Wang*, Zhiqiang Cheng, Dongdong Zhang, Shaopeng Li, Lusheng Song, Wenfei Zhou, Mo Yang, Zhiyou Wang, Zheng Zheng, Baohang Han, Chen Wang, Yanlian Yang, Jinsong Zhu, “SPRi determination of inter-peptide interaction by using 3D supramolecular co-assembly polyrotaxane film”, Biosens. Bioelectron., 2015, 66, 38-44. (*Co-first author)
 

Timothy J. Smith, Chenxuan Wang, Nicholas L. Abbott, “Influence of self-assembling redox mediators on charge transfer at hydrophobic electrodes”, Langmuir, 2015, 31, 10638–10648.

 

Yang Sun, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, “Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice”, Part Fibre Toxicol., 2015, 12, 4.

 

2014 Publications

Yiqun Bai, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott, “Liquid crystals anchored on mixed monolayers of chiral versus achiral molecules: continuous change in orientation as a function of enantiomeric excess”, Angew. Chem. Int. Ed., 2014, 53, 8079-8083.

 

Huiwen Du, Denghua Li, Yibin Wang, Chenxuan Wang, Ping Li, Yanglian Yang, Chen Wang, “Peptide-assisted directional adsorption of purple membrane at the liquid-solid interface”, J. Phys. Chem. C, 2014, 118, 29770-29776.

 

2013 Publications

Min Zhang, Xiaobo Mao, Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang, Wei Liang, Chen Wang, “The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr)”, Biomaterials, 2013, 34, 1383-1390.

 

Min Zhang, Xiaobo Mao, Yue Yu, Chenxuan Wang, Yanlian Yang, Chen Wang, “Nanomaterials for reducing amyloid cytotoxicity”, Adv. Mater., 2013, 25, 3780-3801.

 

Huiwen Du, Denghua Li, Yibing Wang, Chenxuan Wang, Dongdong Zhang, Yanlian Yang, Chen Wang, “Determination of the surface charge density and temperature dependence of purple membrane by electric force microscopy”, J. Phys. Chem B, 2013, 117, 9895-9899.

 

Ting Zhou, Axel Llizo, Ping Li, Chenxuan Wang, Yuanyuan Guo, Mingqi Ao, Linling Bai, Chen Wang, Yanlian Yang, Guiying Xu, “High transfection efficiency of homogeneous DNA nanoparticles induced by imidazolium gemini surfactant as nonviral vector”, J. Phys. Chem. C, 2013, 117, 26573–26581.

 

2012 Publications

Chenxuan Wang, Aihua Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang, Chen Wang, “Observation of molecular inhibition and binding structures of amyloid peptides”, Nanoscale, 2012, 4, 1895-1909.

 

Yuanyuan Guo, Chenxuan Wang, Jingfei Hou, Aihua Yang, Xuemei Zhang, Yibing Wang, Min Zhang, Yanlian Yang, Chen Wang, “Odd-Even Sequence Effect of Surface-Mediated Peptide Assemblies Observed by Scanning Tunneling Microscopy”, Chin. J. Chem., 2012, 30, 1987-1991.

 

Jie Song, Menglin Chen, Viduthalai Regina, Chenxuan Wang, Rikke Meyer, Erqing Xie, Chen Wang, Flemming Besenbacher, Mingdong Dong, “Safe and effective Ag nanoparticles immobilized antimicrobial nanononwovens”, Adv. Eng. Mater., 2012, 14, B240-B246.

 

Peng Liu, Shuai Zhang, Meisha Chen, Qian Liu, Chenxuan Wang, Chen Wang, Yanmei Li, Flemming Besenbacher, Mingdong Dong, “Co-assembly of human islet amyloid polypeptide (hIAPP)/insulin”, Chem. Commun., 2012, 48, 191-193.

 

2011 Publications

Xiaobo Mao*, Chenxuan Wang*, Xingkui Wu, Lei Liu, Lan Zhang, Lin Niu, Yanlian Yang, Chen Wang, “Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies”, Proc. Natl. Acad. Sci. USA, 2011, 108, 19605-19610. (*Co-first author)

 

Chenxuan Wang, Xiaobo Mao, Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibin Wang, Yanlian Yang, Chen Wang, “Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy”, Chem. Commun., 2011, 47, 10638-10640.

 

Xiaobo Mao, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Liu, Qingdao Zeng, Yanlian Yang, Chen Wang, “Molecular level studies on binding modes of labeling molecules with polyalanine peptides”, Nanoscale, 2011, 3, 1592-1599.

 

Xiaobo Mao, Yuanyuan Guo, Chenxuan Wang, Min Zhang, Xiaojing Ma, Lei Liu, Lin Liu, Qingdao Zeng, Yanlian Yang, Chen Wang, “Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy”, ACS Chem. Neurosci., 2011, 2, 281-287.

 

Zengguang Cheng, Qiaoyu Zhou, Chenxuan Wang, Qiang Li, Chen Wang, Ying Fang, “Toward intrinsic graphene surfaces: a systematic study on thermal annealing and wet-chemical treatment of SiO2-supported graphene devices”, Nano Lett., 2011, 11, 767-771.

 

Jie Song, Menglin Chen, Mikkel Buster Olesen, Chenxuan Wang, Rasmus Havelund, Qiang Li, Erqing Xie, Rong Yang, Peter Boggild, Chen Wang, Flemming Besenbacher, Mingdong Dong, “Direct electrospinning of Ag/polyvinylpyrrolidone nanocables”, Nanoscale, 2011, 3, 4966-4971.

 

Weiwei He, Shuai Hou, Xiaobo Mao, Xiaochun Wu, Yinglu Jin, Jianbo Liu, Xiaona Hu, Ke Zhang, Chenxuan Wang, Yanlian Yang, Qi Wang, “Peptide-tailored assembling of Au nanorods”, Chem. Commun., 2011, 47, 5482-5484.

 

2010 Publications

Xiaobo Mao, Chenxuan Wang, Lei Liu, Xiaojing Ma, Lin Niu, Yanlian Yang, Chen Wang, “Study on the fine structure of polypeptides at solid-liquid interfaces by scanning tunneling microscopy”, Acta Physico-Chimica Sinica, 2010, 26, 850-861.

 

Xuemei Zhou, Hongchao Yang, Chenxuan Wang, Yinfang Cui, Xiaobo Mao, Cong Wang, Yinshu Wang, Gang Liu, “Visible light induced photocatalytic degradation rhodamine B on one-dimensional iron oxide particles”, J. Phys. Chem. C, 2010, 114, 17051-17061.

 

Xiaobo Mao, Hongchao Yang, Xuemei Zhou, Chenxuan Wang, Yinshu Wang, Yanlian Yang, Chen Wang, Gang Liu, “Straight and Branched Goethite Topology by Oriented Attachment at High pH”, Cryst. Growth Des., 2010, 10, 504-509.

 

Tao Zhang, Zengguang Cheng, Yibing Wang, Zhongjun Li, Chenxuan Wang, Yibao Li, Ying Fang, “Self-assembled 1-octadecanethiol monolayers on graphene for mercury detection” Nano Lett., 2010, 10, 4738-4741.

 

Hongchao Yang, Xuemei Zhou, Tengteng Tang, Xiaoying Qi, Chenxuan Wang, Jinyao Lan, Yinshu Wang, Yanlian Yang, Gang Liu, “Anisotropic growth of multi-twinned goethite particles by oriented aggregation”, Cryst. Eng. Comm., 2010, 12, 4007-4009.

 

Jie Jiang, Xiaoliang Tang, Wei Dou, Huihui Zhang, Weisheng Liu, Chenxuan Wang, Jiangrong Zheng, “Synthesis and characterization of the ligand based on benzoxazole and its transition metal complexes: DNA-binding and antitumor activity”, J. Inorg. Biochem., 2010, 104, 583-591