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生物医学工程学系

张卫奇

张卫课题组

 



张卫奇,生物医学工程系课题组长,副研究员,硕士生导师

2004.09-2008.07于湖南师范大学生物技术专业获学士学位

2008.09-2013.07于北京协和医学院生物医学工程专业获博士学位

2014.02-2018.12 在康奈尔大学医学院放射医学系做博士后研究

2019.02加入中国医学科学院基础医学研究所&北京协和医学院基础学院生物医学工程系,任课题组长。课题组同时隶属于医学分子生物学国家重点实验室。目前,作为负责人承担了北京市科技新星计划中国医学科学院创新工程子课题协和青年基金和国家重点实验室自主课题等课题任务。

 

 

研究方向:

课题组主要研究领域为药物递送与分子影像,旨在利用基础医学、生物学、药学与材料学等多学科交叉的研究手段,提高肿瘤等疾病治疗和诊断的效率。相关成果已在ACS NanoBiomaterialsJournal of Controlled ReleaseACS Applied Materials & InterfacesChemical Communications等专业期刊发表论文29篇,其中第一作者/通讯作者(含共同)论文18篇。申请中国专利3项,参与制定中国国家标准2项。近期课题组研究方向将主要包括

1)以药物-天然生物大分子相互作用为基础的纳米药物载体设计和应用。

2)多功能纳米药物在肿瘤成像与治疗中的应用。

3)纳米生物材料(药物载体)的细胞生物学效应。

 

教学工作:

承担了4+4”临床医学试点班研究生《生物医学工程》《纳米医学概论》课程的部分授课任务。

 

联系方式:

北京市东城区东单三条5号,可胜大 160

电话:010-69155960

邮箱: zwq@ibms.pumc.edu.cn

 

课题组成员:

左起:王慧敏张忆一邓虹张卫奇刘润高梦涵

 

课题组工作人员:



邓虹,博士,助理研究员

2012年于中国科学院化学研究所获博士学位。2012-2020年于中国科学院化学研究所任助理研究员。2020年加入中国医学科学院基础医学研究所任助理研究员。主要研究方向为肿瘤光动力治疗,迄今已在Journal of Medicinal ChemistryJournal of Biomedical NanotechnologyDyes and Pigments 等期刊发表论文10余篇,申请中国专利3项。

 

 

 

 

 

 



张忆一,博士,助理研究员

20211博士毕业于北京科技大学化学专业,同年9加入中国医学科学院基础医学研究所任助理研究员。主要研究方向为纳米药物载体与光热治疗应用,迄今已在Nano Today, Advanced Healthcare MaterialsAnalytica Chimica Acta等期刊发表论文10余篇

 

 

 

 

 

 

课题组学生:

高梦涵,硕士研究生,2019年本科毕业于中央民族大学生物科学专业 (已转博)

王慧敏,硕士研究生2020年本科毕业于中国海洋大学药学专业

刘润萌,硕士研究生2021年本科毕业于四川大学药学专业

 

 

发表论文 (*通讯作者,#第一作者)

  1. 1. W Zhang*, B Du, M Gao, CH Tung*. A hybrid nanogel to preserve lysosome integrity for fluorescence imaging. ACS Nano. 2021, doi: 10.1021/acsnano.1c05864.

  1. 2. H Wang, H Deng, M Gao, W Zhang*. Self-assembled nanogels based on ionic gelation of natural polysaccharides for drug delivery. Frontiers in Bioengineering and Biotechnology. 2021, 9, 703559.

  1. 3. M Gao, H Deng, W Zhang*. Hyaluronan based multifunctional nano-carriers for combination cancer therapy. Current Topics in Medicinal Chemistry. 2021, 21, 126.

  1. 4. D Yan#, H Wei#, X Lai, Y Ge, S Xu, J Meng, T Wen, J Liu, W Zhang*, J Wang*, H Xu*. Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy of refractory acute myeloid leukemia. Journal of Controlled Release. 2020, 327, 766.

  1. 5. W Zhang#, B Han#, X Lai, C Xiao, S Xu, X Meng, Z Li, J Meng, T Wen, X Yang, J Liu, H Xu. Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells. Chemical Communications. 2020, 56, 1255.

  1. 6. W Zhang, CH Tung. Lysosome enlargement enhanced photochemotherapy using a multifunctional nanogel. ACS Applied Materials & Interfaces. 2018, 10, 4343.

  1. 7. W Zhang, CH Tung. Redox-responsive cisplatin nanogel for anticancer drug delivery. Chemical Communications, 2018, 54, 8367.

  1. 8. W Zhang, CH Tung. Real-time visualization of lysosome destruction using a photosensitive toluidine blue nanogel. Chemistry-A European Journal. 2018, 24, 2089.

  1. 9. W Zhang#, X Meng#, H Liu, L Xie, J Liu, H Xu. Ratio of polycations and serum is a crucial index determining the RNAi efficiency of polyplexes. ACS Applied Materials & Interfaces. 2017, 9, 43529.

  1. 10. W Zhang, CH Tung. Sequence-independent DNA nanogel as a potential drug carrier. Macromolecular Rapid Communications. 2017, 38, 1700366.

  1. 11. W Zhang, CH Tung. Cisplatin cross-linked multifunctional nanodrugplexes for combination therapy. ACS Applied Materials & Interfaces. 2017, 9, 854.

  1. 12. W Zhang, Z Zhang, CH Tung, Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels. Chemical Communications. 2017, 53, 779.

  1. 13. W Zhang#, J Liu#, Y Tabata, J Meng, H Xu. The effect of serum in culture on RNAi efficacy through modulation of polyplexes size. Biomaterials, 2014, 35, 567.

  1. 14. W Zhang, Y Ji, X Wu, H Xu. Trafficking of gold nanorods in breast cancer cells: uptake, lysosome maturation and elimination. ACS Applied Materials & Interfaces, 2013, 5, 9856.

  1. 15. W Zhang, Y Ji, J Meng, X Wu, H Xu. Probing the behaviors of gold nanorods in metastatic breast cancer cells based on UV-vis-NIR absorption spectroscopy. PLoS one, 2012, 7, e31957.

  1. 16. W Zhang#, J Meng#, Y Ji, X Li, H Kong, X Wu, H Xu. Inhibiting metastasis of breast cancer cells in vitro using gold nanorod-siRNA delivery system, Nanoscale, 2011, 3, 3923.

  1. 17. X Cheng#, W Zhang#, Y Ji, J Meng, H Guo, J Liu, X Wu, H Xu. Revealing silver cytotoxicity using Au Nanorods/Ag shell nanostructures: disrupting cell membrane and causing apoptosis through oxidative damage, RSC advances, 2013, 3, 2296.

  1. 18. W Zhang, H Xu. Tailoring the RNAi efficiency of polyplexes. Bioengineered. 2014, 5, 152.

  1. 19. SK Lee, MS Han, W Zhang, CH Tung. Multilayered activatable nanoprobe for ultra-bright tumor imaging. Macromolecular Bioscience. 2019, 19, 1900260.
  2. 20. B Du, W Zhang, CH Tung. A multiresponsive nanohybrid to enhance the lysosomal delivery of oxygen and photosensitizers. Chemistry–A European Journal. 2019, 25, 12801.
  3. 21. H Guo, H Kommidi, UB Maachani, JC Voronina, W Zhang, RS Magge, J Ivanidze, AP Wu, MM Souweidane, O Aras, R Ting. An [18F]-positron emitting fluorophore allows safe evaluation of small molecule distribution in the CSF, CSF Fistulas, and CNS device placement. Molecular Pharmaceutics. 2019, 16, 3636.
  4. 22. H Guo, H Kommidi, Y Vedvyas, JE McCloskey, W Zhang, N Chen, F Nurili, AP Wu , HB Sayman, O Akin, EA Rodriguez, O Aras, MM Jin, R Ting. A fluorescent,[18F]-positron-emitting agent for imaging prostate-specific membrane antigen allows genetic reporting in adoptively transferred, genetically modified cells. ACS Chemical Biology. 2019, 14, 1449.
  5. 23. B Du, W Zhang, CH Tung. Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy. Chemical Communications. 2019, 55, 5926.
  6. 24. TS Lee, Y Kim, W Zhang, IH Song, CH Tung. Facile metabolic glycan labeling strategy for exosome tracking. Biochim Biophys Acta. 2018, 1862, 1091.
  7. 25. W Ma, J Liu, J Xie, X Zhang , H Zhou, H Yao, W Zhang, D Guo, L Zhu, L Xiao, D Wu, H Xu, S Chen, Y Zhao. Modulating the growth and imatinib sensitivity of chronic myeloid leukemia stem/progenitor cells with pullulan/microRNA nanoparticles in vitro. Journal of Biomedical Nanotechnology. 2015, 11, 1961.
  8. 26. J Meng, Y Ji, J Liu, X cheng, H Guo, W Zhang, X Wu, H Xu. Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice, Nanotoxicology, 2014, 8, 686.
  9. 27. J Meng, X Cheng, Jian Liu, W Zhang, X Li, H Kong, H Xu. Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation. PLoS one, 2012, 7, e38995.
  10. 28. M Yang, J Meng, X Cheng, J Lei, H Guo, W Zhang, H Kong, H Xu. Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis. Theranostics, 2012, 2, 258.
  11. 29. J Meng, M Yang, F Jia, H Kong, W Zhang, C Wang, J Xing, S Xie, H Xu. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity. Nanotechnology, 2010, 21, 145104.