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生物医学工程学系

张卫奇



张卫奇,生物医学工程系课题组长,副研究员。2004.09-2008.07于湖南师范大学生物技术专业获学士学位。2008.09-2013.07于北京协和医学院生物医学工程专业获博士学位。2014.02-2018.12 在康奈尔大学医学院放射医学系做博士后研究。2019.02加入中国医学科学院基础医学研究所&北京协和医学院基础学院,任课题组长。课题组同时隶属于医学分子生物学国家重点实验室。目前,作为负责人承担了北京市科技新星计划,中国医学科学院创新工程子课题,协和青年基金和国家重点实验室自主课题等课题任务。

 

课题组主要研究领域为药物递送与分子影像,旨在利用基础医学、生物学、药学与材料学等多学科交叉的研究手段,提高肿瘤等疾病治疗和诊断的效率。相关成果已在BiomaterialsJournal of Controlled ReleaseACS Applied Materials & InterfacesNanoscaleChemical Communications等专业期刊发表论文27篇,其中第一作者/通讯作者论文16篇。申请中国专利3项,参与制定中国国家标准2项。近期课题组研究方向将主要包括

1)以药物-天然生物大分子相互作用为基础的纳米药物载体设计和应用。

2)多功能纳米药物在肿瘤成像与治疗中的应用。

3)纳米生物材料(药物载体)的细胞生物学效应。

 

课题组成员:

邓虹,博士,助理研究员。2007年江西师范大学化学学士,2012年于中国科学院化学研究所获博士学位。2012-2020年于中国科学院化学研究所任助理研究员。2020年加入中国医学科学院基础医学研究所任助理研究员。主要研究领域为肿瘤光动力治疗,迄今已在Journal of Medicinal ChemistryJournal of Biomedical NanotechnologyDyes and Pigments 等期刊发表论文10余篇,申请中国专利3项。

高梦涵,硕士研究生,2019年本科毕业于中央民族大学生物科学专业

王慧敏,硕士研究生,2020年本科毕业于中国海洋大学药学专业

 

联系方式:

北京市东城区东单三条5号,老科研楼 160

电话,010-69155960;邮箱, zwq@ibms.pumc.edu.cn

 

发表论文 (*通讯作者,#第一作者) 

1. M Gao, H Deng, W Zhang*. Hyaluronan based multifunctional nano-carriers for combination cancer therapy. Current Topics in Medicinal Chemistry. 2020, in press.

2. D Yan#, H Wei#, X Lai, Y Ge, S Xu, J Meng, T Wen, J Liu, W Zhang*, J Wang*, H Xu*. Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy of refractory acute myeloid leukemia. Journal of Controlled Release. 2020, 327, 766.

3. W Zhang#, B Han#, X Lai, C Xiao, S Xu, X Meng, Z Li, J Meng, T Wen, X Yang, J Liu, H Xu. Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells. Chemical Communications. 2020, 56, 1255.

4. W Zhang, CH Tung. Lysosome enlargement enhanced photochemotherapy using a multifunctional nanogel. ACS Applied Materials & Interfaces. 2018, 10, 4343.

5. W Zhang, CH Tung. Redox-responsive cisplatin nanogel for anticancer drug delivery. Chemical Communications, 2018, 54, 8367.

6. W Zhang, CH Tung. Real-time visualization of lysosome destruction using a photosensitive toluidine blue nanogel. Chemistry-A European Journal. 2018, 24, 2089.

7. W Zhang#, X Meng#, H Liu, L Xie, J Liu, H Xu. Ratio of polycations and serum is a crucial index determining the RNAi efficiency of polyplexes. ACS Applied Materials & Interfaces. 2017, 9, 43529. 

8. W Zhang, CH Tung. Sequence-independent DNA nanogel as a potential drug carrier. Macromolecular Rapid Communications. 2017, 38, 1700366.

9. W Zhang, CH Tung. Cisplatin cross-linked multifunctional nanodrugplexes for combination therapy. ACS Applied Materials & Interfaces. 2017, 9, 854.

10. W Zhang, Z Zhang, CH Tung, Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels. Chemical Communications. 2017, 53, 779.

11. W Zhang#, J Liu#, Y Tabata, J Meng, H Xu. The effect of serum in culture on RNAi efficacy through modulation of polyplexes size. Biomaterials, 2014, 35, 567.

12. W Zhang, Y Ji, X Wu, H Xu. Trafficking of gold nanorods in breast cancer cells: uptake, lysosome maturation and elimination. ACS Applied Materials & Interfaces, 2013, 5, 9856.

13. W Zhang, Y Ji, J Meng, X Wu, H Xu. Probing the behaviors of gold nanorods in metastatic breast cancer cells based on UV-vis-NIR absorption spectroscopy. PLoS one, 2012, 7, e31957.

14. W Zhang#, J Meng#, Y Ji, X Li, H Kong, X Wu, H Xu. Inhibiting metastasis of breast cancer cells in vitro using gold nanorod-siRNA delivery system, Nanoscale, 2011, 3, 3923. 

15. X Cheng#, W Zhang#, Y Ji, J Meng, H Guo, J Liu, X Wu, H Xu. Revealing silver cytotoxicity using Au Nanorods/Ag shell nanostructures: disrupting cell membrane and causing apoptosis through oxidative damage, RSC advances, 2013, 3, 2296.

16. W Zhang, H Xu. Tailoring the RNAi efficiency of polyplexes. Bioengineered. 2014, 5, 152.

17. SK Lee, MS Han, W Zhang, CH Tung. Multilayered activatable nanoprobe for ultra-bright tumor imaging. Macromolecular Bioscience. 2019, 19, 1900260.

18. B Du, W Zhang, CH Tung. A multiresponsive nanohybrid to enhance the lysosomal delivery of oxygen and photosensitizers. Chemistry–A European Journal. 2019, 25, 12801.

19. H Guo, H Kommidi, UB Maachani, JC Voronina, W Zhang, RS Magge, J Ivanidze, AP Wu, MM Souweidane, O Aras, R Ting. An [18F]-positron emitting fluorophore allows safe evaluation of small molecule distribution in the CSF, CSF Fistulas, and CNS device placement. Molecular Pharmaceutics. 2019, 16, 3636.

20. H Guo, H Kommidi, Y Vedvyas, JE McCloskey, W Zhang, N Chen, F Nurili, AP Wu , HB Sayman, O Akin, EA Rodriguez, O Aras, MM Jin, R Ting. A fluorescent,[18F]-positron-emitting agent for imaging prostate-specific membrane antigen allows genetic reporting in adoptively transferred, genetically modified cells. ACS Chemical Biology. 2019, 14, 1449.

21. B Du, W Zhang, CH Tung. Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy. Chemical Communications. 2019, 55, 5926.

22. TS Lee, Y Kim, W Zhang, IH Song, CH Tung. Facile metabolic glycan labeling strategy for exosome tracking. Biochim Biophys Acta. 2018, 1862, 1091.

23. W Ma, J Liu, J Xie, X Zhang , H Zhou, H Yao, W Zhang, D Guo, L Zhu, L Xiao, D Wu, H Xu, S Chen, Y Zhao. Modulating the growth and imatinib sensitivity of chronic myeloid leukemia stem/progenitor cells with pullulan/microRNA nanoparticles in vitro. Journal of Biomedical Nanotechnology. 2015, 11, 1961.

24. J Meng, Y Ji, J Liu, X cheng, H Guo, W Zhang, X Wu, H Xu. Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice, Nanotoxicology, 2014, 8, 686.

25. J Meng, X Cheng, Jian Liu, W Zhang, X Li, H Kong, H Xu. Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation. PLoS one, 2012, 7, e38995.

26. M Yang, J Meng, X Cheng, J Lei, H Guo, W Zhang, H Kong, H Xu. Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis. Theranostics2012, 2, 258.

27. J Meng, M Yang, F Jia, H Kong, W Zhang, C Wang, J Xing, S Xie, H Xu. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity. Nanotechnology2010, 21, 145104.