导师简介(新增)

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    2019-12-10
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朱蕾


朱蕾,医学博士,教授,研究生导师。现任中国药理学会抗炎免疫药理专业委员会委员,中国药理学会抗炎免疫药理专业委员会青年委员会常务委员,中国药理学会表观遗传药理学专业委员会委员,《医药导报》青年编委,教育部学位中心评议专家,北京市自然科学基金评审专家。2016年,获“中国药理学会青年药理学家奖”。

承担和参与包括国家自然科学基金、科技部“十一五”和“十二五”重大新药创制科技重大专项、中国医学科学院医学与健康科技创新工程项目等多项课题。发表研究论文三十余篇,担任British Journal of PharmacologyJournal of Pharmacology and Experimental TherapeuticsBrain Behavior and ImmunityEuropean Journal of Inflammation等杂志审稿人。

 

研究方向:

1. 抗炎免疫药理学:炎症免疫性疾病发病机制、新靶点及新药物研究,并采用小分子探针技术,结合细胞生物学和分子生物学方法,进行药物靶分子筛选和作用机制探讨。

2. 创新药物基础和临床研究:新型抗自身免疫性疾病药物羧胺三唑的临床前研究以及羧胺三唑临床新用途的研究,并与北京协和医院风湿免疫科协作开展相关转化医学研究。

 

联系方式:

E-mail:

leizhu2004@126.com

Tel: 010-69156402

 

代表性论文:

1.   Shan Lu, Mengyuan Duan, Zehao Guo, Yongting Zhou, Danwei Wu, Xiaojuan Zhang, Yicheng Wang, Caiying Ye, Rui Ju, Juan Li, Dechang Zhang, Lei Zhu.  Carboxyamidotriazole exerts anti-inflammatory activity in lipopolysaccharide‑induced RAW264.7 macrophages by inhibiting NF-κB and MAPKs pathways. Exp Ther Med. 2020, 20: 1455-1466.

2.   Bingqing Zhang, Mengyuan Duan, Bo Long, Baozhong Zhang, Dongmei Wang, Yun Zhang, Jialin Chen, Xiaoming Huang, Yang Jiao, Lei Zhu, Xuejun Zeng. Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes. Mol Med Rep. 2019, 20: 1645-1654.

3.   Ting-Ting Zhang, Rui Xue, Shi-Yong Fan, Qiong-Yin Fan, Lei An, Juan Li, Lei Zhu, Yu-Hua Ran, Li-Ming Zhang, Bo-Hua Zhong, Yun-Feng Li, Cai-Ying Ye, You-Zhi Zhang. Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord. J Neuroinflammation. 2018, 5: 176.

4.   Xiaowan Du, Wei Chen, Yufeng Wang, Chen Chen, Lei Guo, Rui Ju, Juan Li, Dechang Zhang, Lei Zhu, Caiying Ye. Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation. Int Immunopharmacol. 2017, 45: 16-25.

5.   Ting-ting Zhang, Rui Xue, Lei Zhu, Juan Li, Qiong-yin Fan, Bo-hua Zhong, Yun-feng Li, Cai-ying Ye, and You-zhi Zhang. Evaluation of the analgesic effects of ammoxetine, a novel potent serotonin and norepinephrine reuptake inhibitor. Acta Pharmacol Sin. 2016, 37: 1154-1165. 

6.   Lei Zhu, Juan Li, Lei Guo, Xiaoli Yu, Danwei Wu, Lifeng Luo, Lingzhi Zhu, Wei Chen, Chen Chen, Caiying Ye, Dechang Zhang. Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis. Brit J Pharmacol. 2015, 172: 3446-3459.