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陈等

陈等,男,1994年毕业于兰州医学院预防医学系,获医学学士学位。1997年毕业于西安医科大学公共卫生学院劳动卫生与卫生毒理学专业,获医学硕士学位。2003年毕业于中国医学科学院基础医学研究所生物化学与分子生物学专业,获理学博士学位。2004.11-2010.7在美国伯明翰阿拉巴马大学医学院药理毒理学系及综合癌症中心做博士后。201012至今在中国医学科学院基础医学研究所生物化学与分子生物学系工作,副研究员,硕士研究生导师,主要研究方向为肿瘤发病分子机制和真核基因表达调控等目前主持国家自然科学基金面上项目一项,参加中国医学科学院医学与健康科技创新工程项目一项。


联系方式:

地址:北京市东城区东单三条5号医科院基础所老科研楼658房间

邮编:100005

电话:010-69156980

Email: chendeng2001@hotmail.com

 

代表性论文#第一作者,*通讯作者):

1. Zhao W#, Zhang S, Wang X, Ma X, Huang B, Chen H, Chen D*. ETS1 targets RYBP transcription to inhibit tumor cell proliferation. Biochem Biophys Res Commun.2019, 509(3):810-816.

2. Li Meng#, Zhang Shiqiang, Zhao Wen, Hou Congcong, Ma Xiaoli, Li Xuekun, Huang Bingren, Chen Hong, Chen Deng*. RYBP modulates stability and function of Ring1B through targeting UBE3A. FASEB J. 2019, 33(1):683-695.

3. Zhao Q#, Cai W#, Zhang X, Tian S, Zhang J, Li H, Hou C, Ma X, Chen H, Huang B*Chen D*. RYBP expression is regulated by KLF4 and Sp1 and is related to hepatocellular carcinoma prognosis. J Biol Chem. 2017, 292(6):2143-2158.

4. Tan K#, Zhang X#, Cong X, Huang B, Chen H*, Chen D*. Tumor suppressor RYBP harbors three nuclear localization signals and its cytoplasm-located mutant exerts more potent anti-cancer activities than corresponding wild type. Cell Signal. 2017, 29(1):127-137.

5. Ma W#, Zhang X#, Li M, Ma X, Huang B, Chen H*, Chen D*. Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway. Cell Signal. 2016, 28(8):779-87.

6. Tian S, Hui X, Fan Z, Li Q, Zhang J, Yang X, Ma X, Huang B*, Chen D*, Chen H*. Suppression of hepatocellular carcinoma proliferation and hepatitis B surface antigen secretion with interferon-l1 and PEG-interferon-l1. FASEB J. 2014, 28(8):3528-39.

7. Zhang J, Ma W, Tian S, Fan Z, Ma X, Yang X, Zhao Q, Tan K, Chen H*, Chen D*, Huang BR*. RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI. Cell Signal. 2014, 26(1): 162–172.

8. Chen D#, Wang W, Qin JJ, Wang MH, Murugesan S, Nadkarni DH, Velu SE, Wang H, Zhang R*. Identification of the ZAK-MKK4-JNK-TGFβSignaling Pathway as a Molecular Target for Novel Synthetic Iminoquinone Anticancer Compound BA-TPQ. Curr Cancer Drug Targets. 2013, 13(6): 651-660.

9. Chen D#, Zhang J, Li M, Rayburn ER, Wang H, Zhang R*. RYBP stabilizes p53 by modulating MDM2. EMBO Rep. 2009, 10(2): 166-72.

10. Chen D#, Zhang Z#, Li M, Wang W, Li Y, Rayburn E R, Hill D L, Wang H* and Zhang R*. Ribosomal protein S7 as a novel modulator of p53–MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.  Oncogene. 2007, 26(35):5029–37.

11. Chen D#, Zhang JW*, Zhang ZX, Wu YN, Qu QM. Association of a2-macroglobulin polymorphisms and Alzheimer disease in Mainland Chinese. J Neurol Sci. 2004, 217(1):13-15.

12. Li XQ#, Chen D#, Zhang ZX, Qu QM, Zhang JW*. Genetic Association between Cathepsin D Polymorphism and Alzheimer’s Disease in Chinese Han Population. Dement Geriatr Cogn Disord. 2004,18(2):115-119.