Neuroscience Center of Chinese Academy of Medical Sciences(NC, CAMS) was established in May 2013, which was anchored in IBMS, CAMS. In recent two years, the work of NC was carried out around research of major brain disease, brain disease study unique or with high incidence for Chinese people, establishment of Chinese brain database of major brain disease, systematically establishment of brain disease transgenic non-human primate models, innovative medicine and diagnosis treatment technology development for mentioned diseases above.

NC has been founded for 9 years. Through the communication and cooperation with members of NC and experts of neuroscience field at home and abroad, the academic level of neuroscience of Chinese Academy of Medical Sciences has gained much improvement, with collaboration in basic study, clinical treatment, animal model, medicine development etc.

The center will operate to a greater lever in 2022, since we have produced a batch of original results in research of major brain diseases, such as confirming that the level of BICD2 methylation in peripheral blood of patients with depression is increased and depression behavior of mice is alleviated by Bicd2 knockdown in hippocampus, which was published in PNAS journal. It was found that METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signal and promotes tumor progression of SHH medulloblastoma. Also, these research results were published in Cell Reports, and it was found that AMFR mediated ubiquitination regulates EAAT2 polymerization, which is a potential therapeutic target for intractable epilepsy. Additionally, the results were published in JCI Insight. To note, our members have carried out foreign cooperation, such as cooperating with Institute of Electronics of Chinese Academy of Sciences to develop a multifunctional microelectrode array chip, which is able to detect electrophysiology and dopamine exocytosis of dopaminergic neurons derived from human embryonic stem cells with high sensitivity, all of which were published in Biosensors and Bioelectronics.

Executive Deputy Director: Qi Xu

Deputy Directors: Liying Cui, Naihong Chen, Chao Ma

PI: Xue Zhang, Xiaozhong Peng, Lianfeng Zhang, Weimin Tong, Tao Yin, Yousong Ye