Nanomedicine Center of Chinese Academy of Medical Sciences was established in 2006 by CAMS and attached to Institute of basic Medical Sciences(IBMS). The aim of the center is to build aplatform for scientists in CAMS to collaborate and exchange academic ideas. Recently,research groups for nanomedicine mainly distribute in Institute of Basic Medical Sciences, Institute of Medicinal Plant Development and Cancer Hospital of Chinese Academy of Medical Sciences. Research directions include, nanodrugs and smart delivery system, bio-inspired nanomaterials for regenerative medicine, nanoparticles for molecular Imaging and safety evaluation of nanotechnology. In 2009,IBMS was approved as Convener of the working group of Health, Safety and Environment by National Technical Committee on Nanotechnology of Standardization Administration of China (SAC/TC279/WG6).

In 2022, WG6 recommended 7 proposals to SAC/TC279. Meanwhile, 6 projects have been completed and 3 new proposals have been approved by SAC. WG6 also actively organized and promoted development of international and national standards, andinternational project “Nanotechnologies Assessment of peroxidase-like activity of metal and metal oxide nanoparticles” (ISO/WD TS 5094) has been completed in particular and will be released in Feb. 2023. Additionally,national project “Nanotechnology Vocabulary Nanozyme" has been submitted for publication.

In terms of scientific research, Haiyan Xu’s lab has reported a novel conductive composite hydrogel composed of carbon fibers and biodegradable polymers for the repair of cardiac tissue post myocardial infarct(Materials Today Bio). They also designed a novel CD123 antagonistic peptide with significant antitumor activity in refractory AML mice(ACS AMI). In addition, their team developed a co-delivery system for CXCR4 antagonistic peptide and chemotherapeutics for treatment of refractory AML(Pharmacological Research). What’s more, prof. Jian Liu of XU’s lab developed a novel delivery strategy to realize a high RNAi efficacy on different genes in multiple leukemia cells by combining spermine modified pullulan with desloratadine(Carbohydrate Polymer). In collaboration with Capital Institute of Pediatrics, Dr. Tao Wen of Xu’s lab reported distribution behaviors of Au@Pt nanorods in mice intravenously, which is of greatimportance to evaluate application safety in vivo(International J of Nanomed). Apart from this, Chenxuan Wang’s lab revealed non-additivity between hydrophobic interactions and cationic amino acids that are proximally located within 1 nm of nonpolar regions of a coiled coil supersecondary structure(J Colloid and Interface Sci), designing a peptide exhibiting high-affinity for the spike protein of wild type SARS-CoV-2 and variants(ACS AMI and 3 issued Chinese patents), finding the relation between crystalline state and potency of galectin-10 to induce inflammation in chronic rhinosinusitis with nasal polyps(Nano Lett and 3 issued Chinese patents), and studyinghydration free energydependent wettability and antifouling of native protein-inspired homo poly(amino acid) coatings(Eur Polym J).

Director:Professor Haiyan Xu