Ph.D.Supervisor

Email: hemengqi@ibms.pumc.edu.cn

Phone: 010-69166950

Affiliated State Key Laboratories: State Key Laboratory of Respiratory Health and Multicomorbidity

Technology field and major achievements: The research group focuses on biomedical materials and is dedicated to the study of precise diagnosis and treatment of diseases, concentrating on the development of anti-tumor and antibacterial nanomedicines. A series of novel drug delivery systems have been constructed, and a range of highly sensitive methods and new technologies for detecting disease biomarkers have been developed. In recent years, the group has published over 30 SCI papers in international journals such as Advanced Materials, Nano Today, and Analytical Chemistry. The group leader has participated in the National Key R&D Program of China, presided over the National Natural Science Foundation of China, China Postdoctoral Science Foundation Funded Project, Young Elite Scientist Sponsorship Program of the Beijing Association for Science and Technology (2024).

Representativeness:

1. Meng-Qi He, Yongjian Ai*, Wanting Hu, Liandi Guan, Mingyu Ding, Qionglin Liang*. Recent advances of seed-mediated growth of metal nanoparticles: from growth to application. Adv. Mater. 2023, 35, 2211915.

2. Yongjian Ai+, Meng-Qi He+, Hua Sun, Xiaomeng Jia, Lei Wu, Xinyue Zhang, Hong-bin Sun, Qionglin Liang*. Ultra-small high-entropy alloy nanoparticles: efficient nanozyme for enhancing tumor photothermal therapy. Adv. Mater. 2023, 35, 2302335.

3. Meng-Qi He, Yongjian Ai*, Wanting Hu, Xiaomeng Jia, Lei Wu, Mingyu Ding, Qionglin Liang*. Dual-functional capping agent-mediated transformation of silver nanotriangles to silver nanoclusters for dual-mode biosensing. Anal. Chem. 2023, 95, 6130–6137.

4. Meng-Qi He, Yong-Liang Yu*, Jian-Hua Wang*. Biomolecule-tailored assembly and morphology of gold nanoparticles for LSPR applications. Nano Today 2020, 35, 101005.

5. Meng-Qi He, Shuai Chen, Jie Meng, Wei Shi, Kun Wang, Yong-Liang Yu*, Jian-Hua Wang*. Capping ligand size-dependent LSPR property based on DNA nanostructure-mediated morphological evolution of gold nanorods for ultrasensitive visualization of target DNA. Anal. Chem. 2020, 92, 7054–7061.

6. Meng-Qi He, Shuai Chen, Kan Yao, Jie Meng, Kun Wang, Yong-Liang Yu*, Jian-Hua Wang*. Precisely tuning LSPR property via “peptide-encoded” morphological evolution of gold nanorods for quantitative visualization of enzyme activity. Anal. Chem. 2020, 92, 1395–1401.

7. Meng-Qi He, Shuai Chen, Kan Yao, Kun Wang, Yong-Liang Yu*, Jian-Hua Wang. Oriented assembly of gold nanoparticles with freezing-driven surface DNA manipulation and its application in SERS-based microRNA assay. Small Methods 2019, 3, 1900017.

8. Meng-Qi He+, Kun Wang+, Wen-Jing Wang, Yong-Liang Yu*, Jian-Hua Wang*. Smart DNA machine for carcinoembryonic antigen detection by exonuclease III-assisted target recycling and DNA walker cascade amplification. Anal. Chem. 2017, 89, 9292–9298.