Ph.D.Supervisor

Email: tjhuangbo@hotmail.com

Phone: 010-69156447

Affiliated State Key Laboratories: State Key Laboratory of Common Mechanism Research for Major Diseases

Technology field and major achievements: 

In his early years abroad, Professor Huang Bo's research direction was tumor immune escape, and his main research object was myeloid derived suppressor cells. Professor Huang Bo found that a large number of myeloid cells are expressed in the bone marrow of tumor-bearing mice, and found that such cells can significantly inhibit the anti-tumor immune response of T cells, and then promote the progression of tumors. Related work has been published in the journal Cancer research, which has been cited for more than 1200 times. Mediated tumor immune escape, and related work has also been published in Cancer research and has been cited more than 450 times.

At present, the laboratory brings together the core aspects of tumor immunity, tumor metabolism, tumor biomechanical force signal, tumor vesicles and so on to restore the true face of tumors, T cells and metabolism. The main research directions of the laboratory include: 1. Tumor immunity: to elucidate the fundamental scientific issues related to tumor immunity in mechanism; Various methods and models have been used to study tumor immunity and the cellular and molecular mechanisms of tumor immune escape. The cellular and molecular components of the tumor microenvironment and the mechanism of anti-tumor therapy; And the cellular and molecular mechanisms of the formation of tumor microenvironment before metastasis; 2. Tumor immunotherapy: microparticles (vesicles) derived from tumor cells are used as carriers to carry chemotherapy drugs and oncolytic viruses to treat tumors; And to study the chemosensitizing effect of microparticles or as a new oral vaccine; Preclinical mechanism of microparticles in the treatment of malignant tumor patients with pleural effusion and ascites; Tumor-specific T cells were isolated from the peripheral blood of cancer patients and expanded in vitro. 3. Medical Biomechanics: To explore the effect of biomechanics on cell proliferation and differentiation, so as to reveal the mechanism of biomechanical signals in vivo; Using biomechanics to screen cancer stem cells to study the occurrence and development of tumors and to explore new ideas and targets for tumor treatment. To elucidate the physical and mechanical characteristics of stem-like tumor cells. 4. T cell basic biology: T cell memory, thymus atrophy, stem T cell expansion; 5. Metabolism: to answer the core questions such as the nature of glycogen metabolism, why fatty acid oxidation is needed, and the regulation of free radicals.

Since its establishment, the laboratory has published more than 90 SCI articles as corresponding authors in related fields. Includes Science, Science Immunology, Science Translational Medicine, Cancer Cell, Molecular Cell, Nature Materials, Nature Immunology (4 papers), Nature Cell Biology (3 papers), Nature Biomedical Engineering (2 papers) and other international mainstream journals, SCI citations more than 8000 times.

Representativeness: 

1. Chen J, Zhou Y, Liu Z, Lu Y, Jiang Y, Cao K, Zhou N, Wang D, Zhang C, Zhou N, Shi K, Zhang L, Zhou L, Wang Z, Zhang H, Tang K, Ma J, Lv J, Huang B. Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG. Science. 2024 Feb 16;383(6684):eadi3332.

2. Ma J, Tang L, Tan Y, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K,  Zhang Y, Huang B. Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Jan 23.

3. Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X*, Huang B. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1. Nat Immunol. 2023 Dec;24(12):2042-2052.

4. Lv J, Zhou Y, Zhou N, Wang Z, Chen J, Chen H, Wang D, Zhou L, Wei K, Zhang H, Tang K, Ma J, Liu Y, Wan Y, Zhang Y, Zhang H, Huang B. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci Transl Med. 2023 Feb;15(681):eabq6024.

5. Tang K, Zhang H, Deng J, Wang D, Liu S, Lu S, Cui Q, Chen C, Liu J, Yang Y, Li Y, Chen J, Lv J, Ma J, Huang B.Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. Nat Immunol. 2023 Jan;24(1):162-173.

6. Zhang H, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Mol Cell. 2022 Jun 17:S1097-2765(22)00538-X.

7. Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72.

8. Liu Y, Zhou N, Zhou L, Dong B, Zhao Y, Yuan P, Gao Q, Zhang H, Xiao-Feng Qin F, Huang B. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor.Nat Immunol. 2021;22(3):358-69.

9. Zhang H, Tang K, Ma J, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

10. Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y*, Wang X*, Huang B. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020 Jul;4(7):743-53.

11. Liu Y,  Fang Y,  Chen X,  Wang Z,  Liang X,  Lv J,  Tang K,  Xie J,  Gao Y,  Cheng F,  Zhou Y,  Zhang Z,  Hu Y,  Zhang X,  Gao Q,  Zhang Y,  Huang B. Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 2020 Jan 17;5(43):eaax7969.

12. Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Qin FX, Huang B. Tumor repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480-494.

13. Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27.

14. Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N*, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater. 2012 Jul 1;11(8):734-41.