Ph.D.Supervisor

Email:huangyue@pumc.edu.cn

Affiliated State Key Laboratories: State Key Laboratory of Common Mechanism Research for Major Diseases

Technology field and major achievements: My research interest is in using the mice and embryonic stem (ES) cells as model systems to identify and characterise genes involved in important biological processes, especially pluripotent stem cell differentiation, mammalian development and tumorigenesis.

Representativeness:

1. Xiao R, Xu D, Zhang M, Chen Z, Cheng L, Du S, Lu M, Zhou T, Li R, Bai F*, Huang Y*. Aneuploid embryonic stem cells drive teratoma metastasis. Nature Communications. 15(1):1087, 2024.

2. Li M, Yang J, Xiao R, Liu Y, Hu J, Li T, Wu P, Zhang M*, Huang Y*, Sun Y*, Li C*. The effect of trisomic chromosomes on spatial genome organization and global transcription in embryonic stem cells. Cell Proliferation. e13639, 2024.

3. Zuo ZY, Yang GH, Wang HY, Liu SY, Zhang YJ, CaiY, Chen F, Dai H, Xiao Y, Cheng MB, Huang Y*, Zhang Y*. Klf4 methylated byPrmt1 restrains the commitment of primitive endoderm. Nucleic Acids Research, 50(4): 2005-2018, 2022.

4. Wang X, Ping C, Tan P, …., Wang D*, Yu J*, Ma Y*, Huang Y*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternativesplicing of Tbx3 and Bptf. the EMBO Journal, 40 (4): e104729, 2021.

5. Zhang GZ, Li XW, Sun Y, Wang X, Liu G*, Huang Y*. A genetic screen identifiesEtl4-deficiency capable of stabilizing the haploidy in embryonic stem cells. Stem Cell Reports, 16 (1): 29-38, 2021.

6. Yang S, Yang R, Wang H, Huang Y*, Jia Y*. CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress. Am J Pathology, 190(12): 2403-2416, 2020.

7. Rui Yang, Huanmin Wang, … Yuyan Jia* & Yue Huang*. CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development.146(2): dev.169235, 2019.

8. Gaung Liu, Xue Wang,Yufang Liu, Meili Zhang, Tao Cai, Zhirong Shen, Yuyan Jia and Yue Huang*. Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens. Nucleic Acids Research, 45(22): e180, 2017.

9. Meili Zhang, Li Cheng,Yuyan Jia, Guang Liu, Cuiping Li, Shuhui Song, Allan Bradley & Yue Huang*. Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential. the EMBO Journal. 35(21): 2285-2300, 2016. [被选为封面论文，并配以 “News & Views” 专题评论].

10. Yanni Ma, Nan Yao, GuangLiu, ... Yue Huang* & Jia Yu*.  Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells. the EMBO Journal. 34(3): 361–378, 2015.

11. Meili Zhang, Yufang Liu,Guang Liu, Xin Li, Yuyan Jia, Lihong Sun, Liu Wang, Qi Zhou & Yue Huang*. Rapidly Generating Knockout Mice from H19-Igf2 Engineered Androgenetic Haploid Embryonic Stem Cells. Cell Discovery. 1: e15031, 2015.

12. Yue Huang*, Stephen J. Pettitt, Ge Guo, et al, Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system. Nucleic Acids Research, 40(3):e21, 2012.

Others: https://orcid.org/0000-0003-1800-1282