Ph.D. advisor

Email:linjun1990@ibms.pumc.edu.cn

Affiliated State Key Laboratories

State Key Laboratory of Respiratory Health and Multimorbidity

Personal Profile

Lin Jun, Assistant Professor/Researcher and Ph.D. advisor. He is the principal investigator of the Research Group on Molecular Mechanisms of Metabolic Diseases and a member of the Gut Microbiota Branch of the Chinese Society for Biophysics.

Technology field and major achievements

Long-term focus on the role of endogenous substances in the pathogenesis and progression of metabolic diseases, as well as the identification of their host targets: Elucidated the role of bacteriogenic new bile acids in improving metabolic diseases, identified a novel receptor for these compounds, and uncovered the molecular mechanisms underlying their improvement of glucose tolerance; identified the key receptor through which ceramides inhibit fat browning and thermogenesis. As the first (including co-) author, I have published 12 SCI papers in internationally renowned journals such as Cell, Science, Cell Metab., Adv. Sci., and PNAS. This research was recognized as one of the Top Ten Advances in Chinese Life Sciences for 2025.

PUBLICATIONS

1. Lin J#, Nie Q#, Cheng J#, Zhong Y#, Zhang T#, Zhang X#, Ge X#, Ding Y#, Niu C, Gao Y, Wang K, Gao M, Wang X, Chen W, Yun C, Ye C, Xu J, Shaoyong W, Zhang L, Shang P, Luo X, Zhang Z, Zheng X, Sha X, Zhang J, Nie S, Zhang X, Ren F, Liu H, Dong E, Yu X*, Ji L*, Pang Y*, Sun J*, Jiang C*. A microbial amino acid-conjugated bile acid tryptophan-cholic acid improves glucose homeostasis via the orphan receptor MRGPRE. Cell. 2025 August;188, 1-19

2. Lin H#, Ma C#, Cai K#, Guo L#, Wang X#, Lv L#, Zhang C#, Lin J#, Zhang D, Ye C, Wang T, Huang S, Han J, Zhang Z, Gao J, Zhang M, Pu Z, Li F, Guo Y, Zhou X, Qin C, Yi F, Yu X*, Kong W*, Jiang C*, Sun JP*. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025 May;388(6746)

3. Ye C#, Wang X#, Lin J#, Wu C, Gao Y, Guo C, Liao Y, Rao Z, Huang S, Chen W, Huang Y, Sun J, Zhao D*, Jiang C*. Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis.  Sci China Life Sci. 2025 Apr;68(4)

4. Lin J, Liu H, Sun Y, Zou J, Nie Q*, Nie S*. Arabinoxylan Alleviates Obesity by Regulating Gut Microbiota and Bile Acid Metabolism. J Agric Food Chem. 2024 Oct 23;72(42).

5. Zhang Y#, Wang X#, Lin J#, Liu J#, Wang K, Nie Q, Ye C, Sun L, Ma Y, Qu R, Mao Y, Zhang X, Lu H, Xia P, Zhao D, Wang G*, Zhang Z*, Fu W*, Jiang C*, Pang Y*. A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH. Cell metabolism. 2024 Aug 6;36(8)

6. Yan C#, Lin J#, Huang Y#, Gao Q#, Piao Z#, Yuan S, Chen L, Ren X, Ye R, Dong M, Zhang H, Zhou H, Jiang X, Jin W*, Zhou X*, Yan C*. Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle. Zoological research. 2022 Mar 18;43(2):275-284.

7. Jiang X#, Lin J#, Dong M, Liu X, Huang Y, Zhang H, Ye R, Zhou H, Yan C, Yuan S, Chen L, Jiang R, Zheng K, Jin W*. Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime. Frontiers In Physiology. 2022 Aug 16;13:950619.

8. Lin J#, Jiang X#, Dong M, Liu X, Shen Q, Huang Y, Zhang H, Ye R, Zhou H, Yan C, Yuan S, Wu X, Chen L, Wang Y, He M, Tao Y, Zhang Z*, Jin W*. Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue. Advanced science. 2021 Nov;8(21).

9. Zheng Q#, Lin J#, Huang J#, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y*, Jin W*, Zhao J*. Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. Proc Natl Acad Sci USA. 2017, Nov 7, 114(45): E9474-E9482

10. Lin J#, Cao C#, Tao C#, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman JR, Wang Y*, Jin W*, Zhao J*. Cold adaptation in pigs depends on UCP3 in beige adipocytes. Journal of Molecular Cell Biology. 2017, Oct 1;9(5):364-375.