hili Li*, In situ detecting changes in membrane lipid phenotypes of macrophages cultured in different cancer microenvironments using mass spectrometry, Analytica Chimica Acta, 2018, 1026, 101-108.

(7) Yujie Liu, Yunpeng Wu, Yanmin Wang, Mo Zhang, and Zhili Li*，Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes，International Journal of Medical Sciences, 2018, 15(3), 210-216.

(8) Mo Zhang, Yujie Liu, Dan Zhang, Tianjing Chen, Zhili Li*, Facile and Selective Enrichment of Intact Sialoglycopeptides Using Graphitic Carbon Nitride, Analytical Chemistry, 2017, 89(15) , 8064-8069.

(9) Shuai Guo, Dan Zhou, Mo Zhang, Tiejun Li, Yujie Liu, Yupin Xu, Tianjing Chen, Zhili Li*, Monitoring changes of docosahexaenoic acid-containing lipids during the recovery process of traumatic brain injury in rat using mass spectrometry imaging, Scientific Reports, 2017, 7. e5054.

(10) Yumei Guo, Junling Ren, Xiaoou Li, Xiaofeng Liu, Ning Liu, Yanmin Wang, Zhili Li*, Simultaneous Quantification of Serum Multi-Phospholipids as Potential Biomarkers for Differentiating Different Pathophysiological states of lung, stomach, intestine, and pancreas, Journal of Cancer, 2017, 8(12), 2191-2204.

(11) Dan Zhou, Shuai Guo, Mo Zhang, Yujie Liu, Tianjing Chen, Zhili Li*, Mass spectrometry imaging of small molecules in biological tissues using graphene oxide as a matrix, Analytica Chimica Acta, 2017, 962, 52-59.

(12) Junling Ren, Dan Zhang, Yujie Liu, Ruiqing Zhang, Huiling Fang, Shuai Guo, Dan Zhou, Mo Zhang, Yupin Xu, Ling Qiu*, Zhili Li*, Simultaneous Quantification of Serum Nonesterified and Esterified Fatty Acids as Potential Biomarkers to Differentiate Benign Lung Diseases from Lung Cancer, Scientific Reports, 2016, 6, e34201.

(13) Dan Zhang, Bingchao Chen, Yanmin Wang, Peng Xia, Chengyan He, Yujie Liu, Ruiqing Zhang, Mo Zhang, Zhili Li* Disease-specific IgG Fc N-glycosylation as personalized biomarkers to differentiate gastric cancer from benign gastric diseases, Scientific Reports, 2016, 6, e25957.

(14) Manwen He, Shuai Guo, Junling Ren, Zhili Li*, In Situ Characterizing Membrane Lipid Phenotype of Human Lung Cancer Cell Lines Using Mass Spectrometry Profiling, Journal of Cancer, 2016, 7(7), 810-816.

(15) Yaping Zhang, Chengyan He, Ling Qiu, Yanmin Wang, Xuzhen Qin, Yujie Liu, Zhili Li*, Serum unsaturated free fatty acids: a potential biomarker panel for early-stage detection of colorectal cancer, Journal of Cancer, 2016, 7(4), 477-483.

(16) Yujie Liu, Yuanjun Liu, Dan Zhang, Ruiqing Zhang, Zhili Li*, Kapok fiber: a natural biomaterial for highly specific and efficient enrichment of sialoglycopeptides, Analytical Chemistry, 2016, 88(2),1067-1072.

(17) Yujie Liu, Dan Zhang, Yuhang Cheng*, Zhili Li*, Elevated serum immunoinflammation-related protein complexes are associated with psychosis, Psychiatry Research, 2015, 230, 96-101.

(18) Yaping Zhang, Ling Qiu, Chengyan He, Yanmin Wang, Yujie liu, Dan Zhang, Zhili Li*, Serum unsaturated free fatty acids: a potential biomarker panel for differentiating benign thyroid diseases from thyroid cancer, Journal of Cancer, 2015, 6(12), 1276-1281.

(19) Shuai Guo, Yanmin Wang, Dan Zhou, and Zhili Li*, Electric Field-Assisted Matrix Coating Method Enhances the Detection of Small Molecule Metabolites for Mass Spectrometry Imaging, Analytical Chemistry, 2015, 87(12), 5860-5865.

(20) Manwen He, Shuai Guo, Zhili Li*, In situ characterizing membrane lipid phenotype of breast cancer cells using mass spectrometry profiling, Scientific Reports, 2015, 5, e11298.

(21) Manwen He, Shuai Guo, Zhili Li*, Dynamically in situ monitoring lipid changes in DHA-treated breast cells by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry, Rapid Commun Mass Spectrom, 2015, 29(10), 987-990.

(22) Gaoguang Song, Yujie Liu, Yanying Wang, Guanjun Ren, Shuai Guo, Junling Ren, Li Zhang*, Zhili Li*, Personalized biomarkers to monitor disease progression in advanced non-small-cell lung cancer patients treated with icotinib, Clinica Chimica Acta, 2015, 440, 44-48.

(23) Yaping Zhang, Ling Qiu, Yanmin Wang, Chengyan He, Xuzhen Qin, Yujie liu, Zhili Li*, Unsaturated free fatty acids: a potential biomarker panel for early detection of gastric cancer, Biomarkers, 2014, 19(8), 667-673.

(24) Shuai Guo, Yanmin Wang, Dan Zhou, Zhili Li*, Significantly increased monounsaturated lipids relative to polyunsaturated lipids in six types of cancer microenvironment are observed by mass spectrometry imaging, Scientific Reports, 2014, 4, e5959.

(25) Yaping Zhang, Chengyan He, Ling Qiu, Yanmin Wang, Li Zhang, Xuzhen Qin, Yujie Liu, Dan Zhang, Zhili Li*, Serum Unsaturated Free Fatty Acids: Potential Biomarkers for Early Detection and Disease Progression Monitoring of Non-Small Cell Lung Cancer, Journal of Cancer, 2014, 5(8), 706-714.

(26) Yaping Zhang, Lina Song, Ning Liu, Chengyan He*, Zhili Li*, Decreased serum levels of free fatty acids are associated with breast cancer, Clinica Chimica Acta, 2014, 437, 31-37.

(27) Shuai Guo, Ling Qiu, Yanming Wang, Xuzhen Qin, Hui Liu, Manwen He, Yaping Zhang, Zhili Li* and Xiaohong Chen*, Tissue imaging and serum lipidomic profiling for screening potential biomarkers of thyroid tumors by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry, Analytical and Bioanalytical Chemistry, 2014, 406, 4357-4370.

(28) Yaping Zhang, Ling Qiu, Yanmin Wang, Xuzhen Qin, Zhili Li*, High-throughput and high-sensitivity quantitative analysis of serum unsaturated fatty acids by chip-based nanoelectrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry: early stage diagnostic biomarkers of pancreatic cancer. Analyst, 2014, 139 (7), 1697-1706.

(29) Yanying Wang, Gaoguang Song, Yanmin Wang, Ling Qiu, Xuzhen Qin, Hui Liu, Fang Li, Xiaodong Wang, Fenjie Li, Shuai Guo, Yaping Zhang, Zhili Li*, Elevated serum levels of circulating immunoinflammation-related protein complexes are associated with cancer. Journal of Proteome Research, 2014, 13 (2), 710–719.

(30) Guoqiang Chen, Hexiang Li, Ling Qiu, Xuzhen Qin, Hui Liu, Zhili Li*, Change in fucosylated IgG2 Fc-glycoforms in pancreatitis and pancreatic adenocarcinoma: A promising disease classification model. Analytical and Bioanalytical Chemistry, 2014, 406, 267-273.

(31) Yaping Zhang, Yanmin Wang, Shuai Guo, Yumei Guo, Hui Liu, Zhili Li*, Ammonia-treated N-(1-naphthyl) ethylenediamine dihydrochloride as a novel matrix for rapid quantitative and qualitative determination of serum free fatty acids by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry, Analytica Chimica Acta, 2013, 974, 82-89.

(32) Fenjie Li, Xiaodong Wang, Yujie Liu, Hui Liu, Zhili Li* Dephosphorylation of Intact Glycoprotein to Greatly Improve Digestion Efficiency Coupled with Matrix-Assisted Laser Desorption/Ionization- Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Analysis. Analytica Chimica Acta, 2013, 787, 140-147.

(33) Guoqiang Chen, Yanmin Wang, Xuzhen Qin, Hexiang Li, Yumei Guo, Yanying Wang, Hui Liu, Xiaodong Wang, Gaoguang Song, Fang Li, Fenjie Li, Shuai Guo, Ling Qiu, Zhili Li* Change in IgG1 Fc N-linked glycosylation in human lung cancer: Age and sex-related diagnostic potential. Electrophoresis 2013, 34 (16),2407-2416.DOI: 10.1002/elps.201200455.

(34) Guoqiang Chen, Li Zhang, Yanying Wang, Yumei Guo, Hui Liu, Zhili Li*. Probing gender-specific change in IgG1 Fc-galactosylation in non-small cell lung cancer patients treated with epidermal growth factor receptor inhibitor, icotinib hydrochloride, using matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry, Rapid Commun Mass Spectrom 2013, 27(10), 1168-1172.

(35) Fang Li, Xuzhen Qin, Haiquan Chen, Ling Qiu, Yumei Guo, Hui Liu, Guoqiang Chen Gaoguang Song, Xiaodong Wang, Fenjie Li, Shuai Guo, Baohua Wang and Zhili Li*, Lipid profiling for early diagnosis and progression of colorectal cancer using direct-infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry, Rapid Communications in Mass Spectrometry, 2013, 27(1), 24-34.

(36) Yumei Guo, Xianmin Wang, Ling Qiu, Xuzhen Qin, Hui Liu, Yanying Wang, Fang Li, Xiaodong Wang, Guoqiang Chen, Gaoguang Song, Fenjie Li, Shuai Guo, Zhili Li*, Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry, Clinica Chimica Acta, 2012, 414, 135-141.

(37) Xiaodong Wang, Fenjie Li, Gaoguang Song, Shuai Guo, Hui Liu, Guoqiang Chen, Zhili Li*, Broad-spectrum four-dimensional orthogonal electrophoresis: a novel comprehensively feasible system for protein complexomics investigation, Molecular & Cellular proteomics, 2012, 11(9), 786-799.

(38) Guoqiang Chen, Yanmin Wang, Ling Qiu, Xuzhen Qin, Hui Liu, Xiaodong Wang, Yanying Wang, Gaoguang Song, Fang Li, Yumei Guo, Fenjie Li, Shuai Guo, Zhili Li*, Human IgG Fc-glycosylation profiling reveals association with age, sex, female sex hormones and thyroid cancers, Journal of Proteomics, 2012, 75(10), 2824-2834.

(39) Xiaodong Wang, Guoqiang Chen, Hui Liu, Zhiyun Zhao, Zhili Li*，Four-dimensional orthogonal electrophoresis system for screening protein complexes and protein-protein interactions combined with mass spectrometry, Journal of Proteome Research, 2010, 9(10), 5325-5334.

(40) Guoqiang Chen, Hui Liu, Xiaodong Wang, Zhili Li*, In vitro methylation by methanol: Proteomic screening and prevalence investigation, Analytica Chimica Acta, 2010, 661(1), 67-75.

(41) Zhiili Li, Feng Song, Zhihao Zhuang, Debra Dunaway-Mariano and Karen S. Anderson*, Monitoring Enzyme Catalysis in the Multimeric State: Direct Observation of Arthrobacter 4-Hydroxybenzoyl-Coenzyme A Thioesterase Catalytic Complexes using Time-resolved Electrospray Ionization Mass Spectrometry. Analytical Biochemistry, 2009, 394, 209-216.

(42) Zhili Li, Apurba K. Sau, Cristina M. Furdui and Karen S. Anderson*, Probing the role of tightly bound phosphoenolpyruvate in Escherichia coli 3-deoxy-d-manno-octulosonate 8-phosphate synthase catalysis using quantitative time-resolved electrospray ionization mass spectrometry in the millisecond time range, Analytical Biochemistry, 2005, 343(1), 35-47.

(43) Zhili Li, Apurba Sau, Shida Shen, Craig Whitehouse, Timor Baasov and Karen S. Anderson* , A snapshot of enzyme catalysis using electrospray ionization mass spectrometry, Journal of the American Chemical Society，2003,125, 9938-9939.

6. 课题组近5年专利

(1)一种基于氧化铜/氮化碳无酶葡萄糖传感器的制备方法及应用, 申请号：201910433447

(2)一种基于氧化铜/氮化碳无酶葡萄糖传感器的制备方法及应用，申请号：201910269990.1

(3)确定或辅助监测癌症进展的个体化标志物，专利号：ZL201610369521.3.

(4)一种富集分离唾液酸化糖肽的新材料及其应用, 专利号：ZL201610506699.8

(5)一组监测癌症疾病进展和或耐药性产生的个体化标志物,申请号：201510827734.1

(6)一种富集唾液酸化糖肽的材料及其应用，申请号：ZL201510651116.6

(7)一种原位质谱分析的常压离子源装置，专利号：ZL201520119228.2

(8)一种用于质谱成像的基质喷涂装置，专利号：ZL201420766737.x

(9)一种富集唾液酸化糖肽、唾液酸化聚糖或唾液酸化糖苷的方法, 申请号：ZL201410035250.9

(10)蛋白质复合物及其谱以及其在疾病诊断、进展评估和药效评估中的应用， 申请号：PCT/CN2012/071113

二、 许雪梅课题组

1. 课题组简介

疫苗是因传染性疾病的预防所需而问世的，包括传统的急性传染病以及慢性传染病（如HBV及HPV等感染相关疾病），在对抗传染病的中起着十分重要的作用。但目前上市疫苗还存在一些缺陷，主要是保护范围不够理想，如HPV黏膜致癌型约20多型、黏膜低危型约12型，但目前上市的4种HPV病毒样颗粒（VLP）蛋白多价疫苗中，最高的9价苗仅能保护7种致癌型、2种低危型；肠道病毒EV71手足口病灭活苗17年在我国问世应用后，手足口病的发病率并没有下降，目前尚无多价手足口病疫苗的问世；四价流感病毒的保护效率也难以满足流感预防的要求，且会出现预测病毒株与现实流行株不一致，导致疫苗脱靶。本课题组的主要研究方向，首先是采用基因工程重组蛋白技术，研制通用型HPV嵌合病毒样颗粒(cVLP)疫苗、多价手足口病病毒样颗粒疫苗及通用型流感病毒疫苗。目前HPV通用疫苗的专利技术已经转让，该技术为表面展示保守表位的HPV cVLP疫苗，动物实验结果表明多种cVLP联合应用具有协同加强作用，中和不仅没有交叉抑制现象，同时还可协同强化针对部分交叉和型别的中和抗体滴度，具有广谱的交叉中和活性，可至少中和24余种HPV型别，包括所有12种高危型、大部分少见的致癌型，同时还2种主要低危型和4种皮肤型；手足口病多价疫苗及流感病毒通用型疫苗正在进行中。其次是开展各种疫苗佐剂的研究，包括传统的铝佐剂、具有TLR刺激活性的新型小分子化合物佐剂、乳剂及新型复合佐剂等的研究。HPV治疗性疫苗，主要选择与病毒感染及感染相关恶性表型维持必需的癌蛋白为靶抗原，定点突变后消除其转化活性，进行融合各种免疫刺激分子的基因疫苗研究。

2. 课题组负责人介绍

许雪梅，女，1965年出生，博士，研究员，博士生导师，中国医学科学院基础医学研究所 肿瘤病毒疫苗课题组组长。

教育经历：
1983.9-1988.7：山东医科大学 医学学士学位；
1988.8-1991.7：大连医科大学 病理学硕士学位；
1999.8-2002.7：中国协和医科大学基础医学院 博士学位；
2002.12-2004.9：美国芝加哥Loyola大学癌症研究中心，访问学者。
工作经历：
1991.8-1995.7：山东青岛第五人民医院 病理科 主治医师；
1995.7-2002.12：中国医学科学院基础医学研究所 助理研究员、副研究员；
2004.9-至今：中国医学科学院基础医学研究所研究员、病原生物学专业博士生导师，肿瘤病毒课题组组长。

3. 课题组成员介绍

张婷，助理研究员，博士，邮箱：zt_0315@163.com，电话：010-69156442

王志荣，助理研究员，博士，邮箱：zhrwang2012@126.com，电话：010-69156442

4. 课题组主要科研项目

项目级别	项目来源	起止日期	项目名称
国家级	国际科技合作项目	2013.4-2018.4	广谱HPV/HIV嵌合病毒样颗粒疫苗
	国家自然基金面上项目	2011.1-2013.12	HPV L2抗原改造及其高效靶向FcγR的基因工程抗体疫苗的应用基础研究
	国家自然基金面上项目	2020.1-2023.12	以多种RG-1保守表位病毒样颗粒为基础的广谱HPV预防性疫苗的研究
省部级	北京市自然基金面上项目	2016.1-2018.12	联合新型L2多表位抗原及鞭毛蛋白分子内佐剂进行广谱HPV预防性疫苗的研究
院校级	创新工程	2016.9-2020.12	疫苗关键技术创新团队

5. 课题组近5年代表性论文

(1) Ting Zhang, Xue Chen, Guoyang Liao, Meili Hu, Jianqing Xu*, Xuemei Xu*. Induction of cross-neutralizing antibodies by sequential immunization with heterologous papillomavirus L1VLPs and its implications for HPV prophylactic vaccines. Journal of Medical Virology, 2020. Doi: 10.1002/jmv.25690.

(2) Ting Zhang, Xue Chen, Hongyang Liu, Qifeng Bao, Zhirong Wang, Guoyang Liao*, Xuemei Xu*. A rationally designed flagellin-L2 fusion protein induced serum and mucosal neutralizing antibodies against multiple HPV types. Vaccine, 37(30): 4022~4030, 2019.

(3)郝亚茹，张婷，刘洪洋，王志荣，周艳，夏百成，许雪梅*. HPV31 L1 C端截短基因可在昆虫细胞表达体系中高水平制备HPV L1疫苗. 基础医学与临床，39(3): 343-347, 2019.

(4) Xue Chen, Ting Zhang, Hongyang Liu, Yaru Hao, Guoyang Liao, Xuemei Xu*. Displaying 31RG-1 peptide on the surface of HPV16 L1 by use of a human papillomavirus chimeric virus-like particle induces cross-neutralizing antibody responses in mice. Human Vaccines & Immunotherapeutics, 14(8): 2025~2033, 2018.

(5)陈雪，王志荣，刘洪洋，张婷，许雪梅* . 一种可诱发高滴度的针对人乳头瘤病毒HPV16，HPV52，HPV58中和抗体反应的HPV16嵌合病毒样颗粒疫苗的研究. 病毒学报，34(4)：505-514, 2018.

(6)胡美丽，刘洪洋，王志荣，陈雪，张婷，许雪梅*.原核表达系统制备HPV58L1 VLP可诱发高滴度且持久的中和抗体. 现代生物医学进展, 18(3):418-422, 2018.

(7) Xue Chen, Hongyang Liu, Zhirong Wang, Shuo Wang, Ting Zhang, Meili Hu, Liang Qiao, Xuemei Xu*. Human papillomavirus 16L1-58L2 chimeric virus-like particles elicit durable neutralizing antibody responses against a broad-spectrum of human papillomavirus types. Oncotarget, 8(38): 63333~63344, 2017.

(8)张婷，陈雪，刘洪洋，周艳，王志荣，许雪梅*. HPV 31型L2保守中和表位可诱发广谱中和抗体. 基础医学与临床，31(11)：1552-1556, 2017.

(9) Ting Zhang, Hongyang Liu, Xue Chen, Zhirong Wang, Shuo Wang, Chunfeng Qu, Jingzhi Zhang, Xuemei Xu*. Lipidated L2 epitope repeats fused with a single-chain antibody fragment targeting human Fc gamma RI elicited cross-neutralizing antibodies against a broad spectrum of human papillomavirus types. Vaccine, 34(46): 5531~5539, 2016.

6. 课题组近5年专利

(1)      一种乳头瘤病毒嵌合蛋白及其用途，CN201610146109.5（已授权，已转让）

(2)      一种乳头瘤病毒嵌合蛋白及其用途，PCT/CN2017/075402（已授权，已转让）

(3)      截短型人乳头瘤病毒16型L1蛋白及其应用，CN201710153290.7（已授权，已转让）

(4)      截短型人乳头瘤病毒58型L1蛋白及其应用，CN201610147709.3（已授权，已转让）

(5)      一种乳头瘤病毒嵌合蛋白及其用途，CN201610146116.5（已授权）

(6)      一种复合疫苗佐剂及其应用，CN201710152761.2

三、 王晨轩课题组

1. 课题组简介

研究方向：蛋白质的正确折叠与组装是维持人体生理机能的必需。肽链通过精密地调控分子间相互作用自组装形成有序三维分子结构，进一步组装、聚集、相分离，形成执行生理功能的分子机器与无膜细胞器。蛋白质组装稳态失衡是一系列退行性疾病共同的病理生理基础。研究蛋白质组装过程与结构，认识自组装过程中的分子间相互作用的本质与规律，实现对自组装过程与功能的有效调控对蛋白质组装相关疾病的预防和治疗有重要意义，从经典药物治疗到相关新型药物治疗的兴起，从微观层面对发病分子机理的阐述到宏观层面治疗模式的创新，新的认识将在未来改变相关疾病的诊治模式，为患者改善预后带来新的机遇。王晨轩课题组遵循“认识组装-调控组装-利用组装”的研究思路，发展扫描隧道显微术、原子力探针显微术、核磁共振波谱技术、X-射线单晶衍射、光散射等新颖的物理、物理化学方法用于生物大分子的结构测定，在单分子水平理解与重大疾病发生、发展密切相关的蛋白、多肽的折叠、组装结构和过程，认识蛋白、多肽折叠组装过程中的相互作用本质与调控规律。

2. 课题组负责人介绍

王晨轩，男，1986年出生，博士，副研究员，硕士生导师，中国医学科学院基础医学研究所课题组组长。2004-2008年，兰州大学国家理科化学基地班，本科。2008-2013年，中国科学院国家纳米科学中心与清华大学化学系联合培养研究生，物理化学专业。导师王琛研究员、杨延莲研究员、李艳梅教授。研究方向：淀粉样蛋白折叠结构的研究及多肽-药物相互作用。2013年获清华大学理学博士学位。2010年，丹麦奥胡斯大学多学科交叉纳米中心-物理与天文系访问学者。合作导师丹麦皇家科学院院士、中国科学院外籍院士Flemming Besenbacher，董明东教授。研究方向：膜蛋白的超高分辨原子力探针显微术的单分子成像。2013-2018年，美国威斯康星大学麦迪逊校区化学系，化学与生物工程系博士后。合作导师美国工程院院士Nicholas L. Abbott教授，美国科学院院士Samuel H. Gellman教授。研究方向：多肽的折叠结构与单分子力学研究。2018年至今，中国医学科学院基础医学研究所/北京协和医学院基础学院生物物理与结构生物学系工作。

3. 课题组成员介绍

张文博，助理研究员，博士，邮箱： zwb@ibms.pumc.edu.cn，电话：010-69156463

于兰兰，博士后，博士，邮箱：yull@ibms.pumc.edu.cn，电话：010-6915644263

4. 课题组主要科研项目

项目级别	项目来源	起止日期	项目名称
国家级	国家自然基金青年项目	2020.1-2022.12	碳基纳米材料表面多肽折叠结构与调控的单分子水平研究
省部级	创新工程	2018.1-2020.12	《离子通道相关疾病的发病机制及转化研究》子课题《纳米医学技术在皮肤离子通道病方面的应用研究》

5. 课题组近5年代表性论文

(1) Lanlan Yu*, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang#, Yanlian Yang, Chen Wang, Chenxuan Wang#. Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, Science Advances, 2020, 6, eabc1449.

(2) Wenbo Zhang*, Lanlan Yu, Chenxuan Wang#. Intermolecular interactions and self-assembly of peptide-based nanomaterials against human pathogenic bacteria. In: Haiyan Xu, Ning Gu. (eds) Nanotechnology in regenerative medicine and drug delivery therapy. 2020, Springer, Singapore.

(3) Wenbo Zhang*, Lanlan Yu, Tianjiao Ji#, Chenxuan Wang#, Tumor microenvironment-responsive peptide based supramolecular drug delivery system, Frontiers in Chemistry, 2020, 8, 549.

(4) Qize Xuan*, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang#, Yibing Wang#, Ping Wang, Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity, Chemical Communications, 2020, 56, 1633-1636.

(5) Xiaoyun Li*, Zhu Liang*, Jianchao Du*, Zhiqing Wang, Song Mei, Zhiqing Li, Yan Zhao, Dandan Zhao, Yiming Ma, Jun Ye, Jiantao Xu, Yu Zhao, Jiahui Chang, Yuhao Qin, Lanlan Yu, Chenxuan Wang#, Chengyu Jiang#, Herbal decoctosome is a novel form of medicine, Science China-Life Sciences, 2019, 62, 333–348.

6. 课题组近5年专利

(1) 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种低溶血活性的蜂毒肽及其应用。国家发明专利.专利号 ZL201910854177.0

(2) 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种蜂毒肽变体及其应用。国家发明专利.专利号 ZL201910854956.0