多年来专注于蛋白质质量控制、蛋白质翻译后修饰以及蛋白质的结构与功能的关系等研究领域,目前致力于针对肺部疾病的配体陷阱蛋白质药物的创新设计和发展研究,在JBC ,Protein Science,PNAS和Cell等杂志发表SCI论文29篇,其中12篇为一作或通讯作者,曾主持自然科学基金青年项目1项,面上项目2项。
(1) Hong Zhang*; Si Wu; Laura S Itzhaki; Sarah Perrett*; Interaction between huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, Protein Science, 2023, 32(12): e4810 (期刊论文) ( 本人标注: 唯一第一作者, 共同通讯作者 )
(2) Hong Zhang*; Huimin Hu; Si Wu; Sarah Perrett*; Effect of evolution of the C‐terminal region on chaperone activity of Hsp70, Protein Science, 2023, 32(1): e4549 (期刊论文) ( 本人标注: 唯一第一作者, 共同通讯作者 )
(3) Zhouping Hong#; Weibin Gong#; Jie Yang; Sainan Li; Zhenyan Liu; Sarah Perrett*; Hong Zhang*; Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70, Journal of Biological Chemistry, 2023, 299(1): 102723 (期刊论文) ( 本人标注: 共同通讯作者 )
(4) Jie Yang; Weibin Gong; Si Wu; Hong Zhang*; Sarah Perrett*; PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, Journal of Biological Chemistry, 2021, 296: 100210 (期刊论文) ( 本人标注: 共同通讯作者 )
(5) Jie Yang#; Hong Zhang#*; Weibin Gong#; Zhenyan Liu; Huiwen Wu; W. D. Hu; Xinxin Chen; Lei Wang; Si Wu; Chang Chen*; Sarah Perrett*; S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, Journal of Biological Chemistry,
2020, 295(24): 8302-8324 (期刊论文) ( 本人标注: 共同第一作者, 共同通讯作者 )