研究方向： 课题组主要研究领域为药物递送与分子影像，旨在利用基础医学、生物学、药学与材料学等多学科交叉的研究手段，提高肿瘤等疾病治疗和诊断的效率。相关成果已在ACS Nano、Biomaterials、 Journal of Controlled Release、 ACS Materials Letters与Carbohydrate Polymers等专业期刊发表论文35篇，其中第一作者/通讯作者（含共同）论文22篇。申请中国专利3项，参与制定中国国家标准2项。近期课题组研究方向将主要包括： （1）以药物-天然生物大分子相互作用为基础的纳米药物载体设计和应用。 （2）多功能纳米药物在肿瘤成像与治疗中的应用。 （3）纳米生物材料（药物载体）的细胞生物学效应。 教学工作： 研究生课程《生物医学光学》课程负责人，另外承担了八年制、“4+4”临床医学试点班和研究生《生物医学工程》、《纳米医学概论》、《生物物理学》和《生理学的物理分析》课程的部分授课任务。

Hong Deng, Xue Yang, Huimin Wang, Menghan Gao, Yiyi Zhang, Runmeng Liu, Haiyan Xu*, Weiqi Zhang*. Tailoring the surface charges of iron-crosslinked dextran nanogels towards improved tumor-associated macrophage targeting. Carbohydrate Polymers. 2024, 325, 121585.

Menghan Gao, Hong Deng, Yiyi Zhang, Huimin Wang, Runmeng Liu, Wei Hou, Weiqi Zhang*. Hyaluronan nanogel co-loaded with chloroquine to enhance intracellular cisplatin delivery through lysosomal permeabilization and lysophagy inhibition. Carbohydrate Polymers. 2024, 323, 121415.

Huimin Wang, Hong Deng, Menghan Gao, Yiyi Zhang, Runmeng Liu, Wei Hou, Haiyan Xu*, and Weiqi Zhang*. Radiotherapy Potentiates the P-Selectin Targeted Cancer Drug Delivery Based on a Cisplatin and Mitoxantrone Coassembled Fucoidan Nanogel. ACS Materials Letters. 2023, 5, 2843. (Cover Article)

Hua Guo#, Huimin Wang#, Hong Deng, Yiyi Zhang, Xue Yang*, Weiqi Zhang*. Facile preparation of toluidine blue-loaded DNA nanogels for anticancer photodynamic therapy, Frontiers in Bioengineering and Biotechnology. 2023, 11, 1180448.

Weiqi Zhang*, Baoji Du, Menghan Gao, Ching-Hsuan Tung*. A hybrid nanogel to preserve lysosome integrity for fluorescence imaging. ACS Nano. 2021, 15, 16442.

Huimin Wang, Hong Deng, Menghan Gao, Weiqi Zhang*. Self-assembled nanogels based on ionic gelation of natural polysaccharides for drug delivery. Frontiers in Bioengineering and Biotechnology. 2021, 9, 703559.

Menghan Gao, Hong Deng, Weiqi Zhang*. Hyaluronan based multifunctional nano-carriers for combination cancer therapy. Current Topics in Medicinal Chemistry. 2021, 21, 126.

Doudou Yan#, Hui Wei#, Xinning Lai, Yangyang Ge, Shilin Xu, Jie Meng, Tao Wen, Jian Liu, Weiqi Zhang*, Jianxiang Wang*, Haiyan Xu*. Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy of refractory acute myeloid leukemia. Journal of Controlled Release. 2020, 327, 766.

Weiqi Zhang#, Bo Han#, Xinning Lai, Chen Xiao, Shilin Xu, Xianghui Meng, Zifu Li, Jie Meng, Tao Wen, Xiangliang Yang, Jian Liu, Haiyan Xu. Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells. Chemical Communications. 2020, 56, 1255.

Weiqi Zhang, Ching-Hsuan Tung. Lysosome enlargement enhanced photochemotherapy using a multifunctional nanogel. ACS Applied Materials & Interfaces. 2018, 10, 4343.

Weiqi Zhang, Ching-Hsuan Tung. Redox-responsive cisplatin nanogel for anticancer drug delivery. Chemical Communications, 2018, 54, 8367.

Weiqi Zhang, Ching-Hsuan Tung. Real-time visualization of lysosome destruction using a photosensitive toluidine blue nanogel. Chemistry-A European Journal. 2018, 24, 2089.

Weiqi Zhang#, Xianghui Meng#, Huike Liu, Lifei Xie, Jian Liu, Haiyan Xu. Ratio of polycations and serum is a crucial index determining the RNAi efficiency of polyplexes. ACS Applied Materials & Interfaces. 2017, 9, 43529.

Weiqi Zhang, Ching-Hsuan Tung. Sequence-independent DNA nanogel as a potential drug carrier. Macromolecular Rapid Communications. 2017, 38, 1700366.

Weiqi Zhang, Ching-Hsuan Tung. Cisplatin cross-linked multifunctional nanodrugplexes for combination therapy. ACS Applied Materials & Interfaces. 2017, 9, 854.

Weiqi Zhang, Zhe Zhang, Ching-Hsuan Tung. Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels. Chemical Communications. 2017, 53, 779.

Weiqi Zhang#, Jian Liu#, Yasuhiko Tabata, Jie Meng, Haiyan Xu. The effect of serum in culture on RNAi efficacy through modulation of polyplexes size. Biomaterials, 2014, 35, 567.

Weiqi Zhang, Yinglu Ji, Xiaochun Wu, Haiyan Xu. Trafficking of gold nanorods in breast cancer cells: uptake, lysosome maturation and elimination. ACS Applied Materials & Interfaces, 2013, 5, 9856.

Weiqi Zhang, Yinglu Ji, Jie Meng, Xiaochun Wu, Haiyan Xu. Probing the behaviors of gold nanorods in metastatic breast cancer cells based on UV-vis-NIR absorption spectroscopy. PLoS one, 2012, 7, e31957.

Weiqi Zhang#, Jie Meng#, Yinglu Ji, Xiaojin Li, Hua Kong, Xiaochun Wu, Haiyan Xu. Inhibiting metastasis of breast cancer cells in vitro using gold nanorod-siRNA delivery system, Nanoscale, 2011, 3, 3923.

Xuelian Cheng#, Weiqi Zhang#, Yinglu Ji, Jie Meng, Hua Guo, Jian Liu, Xiaochun Wu, Haiyan Xu. Revealing silver cytotoxicity using Au Nanorods/Ag shell nanostructures: disrupting cell membrane and causing apoptosis through oxidative damage, RSC advances, 2013, 3, 2296.

Weiqi Zhang, Haiyan Xu. Tailoring the RNAi efficiency of polyplexes. Bioengineered. 2014, 5, 152.

Tao Wang, Weiqi Zhang, Wanshu Chen, Jie Meng, Qinglin Hu, Jian Liu, Tao Wen, Bing Han, Haiyan Xu. As4S4 nanoparticles promote effective terminal erythropoiesis in bone marrow mononuclear cells from patients with myelodysplastic syndromes. Nano Today, 2023, 52, 101965.

Shilin Xu, Meichen Zhang, Xiaocui Fang, Jie Meng, Haiyan Xing, Doudou Yan, Jian Liu, Yanlian Yang, Tao Wen, Weiqi Zhang, Jianxiang Wang, Chen Wang, Haiyan Xu. A novel CD123-targeted therapeutic peptide loaded by micellar delivery system combats refractory acute myeloid leukemia. Journal of Hematology & Oncology. 2021, 14, 193.

Seung Koo Lee, Myung Shin Han, Weiqi Zhang, Ching-Hsuan Tung. Multilayered activatable nanoprobe for ultra-bright tumor imaging. Macromolecular Bioscience. 2019, 19, 1900260.

Baoji Du, Weiqi Zhang, Ching-Hsuan Tung. A multiresponsive nanohybrid to enhance the lysosomal delivery of oxygen and photosensitizers. Chemistry–A European Journal. 2019, 25, 12801.

Hua Guo, Harikrishna Kommidi, Uday B Maachani, Julia C Voronina, Weiqi Zhang, Rajiv S Magge, Jana Ivanidze, Amy P Wu, Mark M Souweidane, Omer Aras, Richard Ting. An [18F]-positron emitting fluorophore allows safe evaluation of small molecule distribution in the CSF, CSF Fistulas, and CNS device placement. Molecular Pharmaceutics. 2019, 16, 3636.

Hua Guo, Harikrishna Kommidi, Yogindra Vedvyas, Jaclyn E McCloskey, Weiqi Zhang, Nandi Chen, Fuad Nurili, Amy P Wu, Haluk B Sayman, Oguz Akin, Erik A Rodriguez, Omer Aras, Moonsoo M Jin, Richard Ting. A fluorescent, [18F]-positron-emitting agent for imaging prostate-specific membrane antigen allows genetic reporting in adoptively transferred, genetically modified cells. ACS Chemical Biology. 2019, 14, 1449.

Baoji Du, Weiqi Zhang, Ching-Hsuan Tung. Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy. Chemical Communications. 2019, 55, 5926.

Tae Sup Lee, Young Kim, Weiqi Zhang, In Ho Song, Ching-Hsuan Tung. Facile metabolic glycan labeling strategy for exosome tracking. Biochim Biophys Acta. 2018, 1862, 1091.

Wenjuan Ma, Jian Liu, Jundan Xie, Xiuyan Zhang, Haixia Zhou, Hong Yao, Weiqi Zhang, Dawei Guo, Lingying Zhu, Lun Xiao, Depei Wu, Haiyan Xu, Suning Chen, Yun Zhao. Modulating the growth and imatinib sensitivity of chronic myeloid leukemia stem/progenitor cells with pullulan/microRNA nanoparticles in vitro. Journal of Biomedical Nanotechnology. 2015, 11, 1961.

Jie Meng, Yinglu Ji, Jian Liu, Xuelian Cheng, Hua Guo, Weiqi Zhang, Xiaochun Wu, Haiyan Xu. Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice, Nanotoxicology, 2014, 8, 686.

Jie Meng, Xuelian Cheng, Jian Liu, Weiqi Zhang, Xiaojin Li, Hua Kong, Haiyan Xu. Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation. PLoS one, 2012, 7, e38995.

Man Yang, Jie Meng, Xuelian Cheng, Jing Lei, Hua Guo, Weiqi Zhang, Hua Kong, Haiyan Xu. Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis. Theranostics, 2012, 2, 258.

Jie Meng, Man Yang, Fumin Jia, Hua Kong, Weiqi Zhang, Chaoying Wang, Jianmin Xing, Sishen Xie, Haiyan Xu. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity. Nanotechnology, 2010, 21, 145104.