2013年- 至今 中国医学科学院基础医学研究所暨北京协和医学院基础学院，副研究员、研究员

2009年-2013年 中国科学院北京基因组研究所，副研究员

2007年-2009年 日本久留米大学医学部，博士后

2004年-2005年 世界卫生组织国际癌症研究署(IARC/WHO)，博士后

1999年-2003年 日本长崎大学药学部，药学博士

1996年-1999年 中国药科大学生物制药学院，理学硕士

1992年-1996年 中国药科大学生物制药学院，工学学士

以临床重大生命健康问题为驱动、以发现新的早期诊断或治疗靶标为目标，分别从分子、细胞及整体实验动物水平切入系统性研究表观转录标记 RNA m6A 甲基化在肿瘤与神经退行性病变的发生过程中的功能与机制。致力于将基础科研与临床实践实现更好地契合与转化，以达到通过科研成果帮助临床医生解决实际问题的目的。

曾主持和参与多项国家自然科学基金、科技部、北自然以及院校级项目，在Science Advances, Molecular Cell, Cell Reports, Cell Discovery, Genome Biology, Cellular and Molecular Biology Letters, Genomics Proteomics Bioinformatics, Open Biology 等高水平杂志发表 SCI 论文 33篇，引用次数 3000 次以上。

1 Pan, W.#, Yang, L.#, Zhang, Y.#, Chen, Y., Xu, Y., Li, Y., Fu, Y., Ma, C., Liu, C., Li, Q., Liu, H., Wang, H., Xu, Q.*, Tong, W.M.*, Niu, Y.* (2026) Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting m°A-dependent decay of cytosolic mitochondrial mRNAs. Science Advances. 12(25):eadz0887.

2 Li, Y.#, Ding, J.#, Liu, S., Wu, Q., Fu, Y., Li, Q., Lv, A., Liu, C.*, Tong, W.M.*, Niu, Y.* (2025) PP2Acα regulates cerebellar development via phosphorylation-dependent neuronal programs. iScience. 29(1):114352.

3 Wu, S.L.#, Yang, L.#, Huang, C.#, Li, Q., Ma, C., Yuan, F., Zhou, Y., Wang, X.Y., Tong, W.M., Niu, Y.*, Jin, F.*. (2024) Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis. Clinical Epigenetics 16(1):125.

4 Lin, L., Ding, J., Liu, S., Liu, C., Li, Q., Gao, X., Niu, Y.*, Tong, W.M.*. (2024) Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular Neurobiology 62(1):1266-1281.

5 Pan, W., Chen, Y., Xu, Y., Tong, W., and Niu, Y.* (2024). RNA m6A methylation and Alzheimer’s Disease: current evidence and future perspectives. Human Brain 3(1).

6 Zhang, Z.W.#, Teng, X.#, Zhao, F.#, Ma, C.#, Zhang, J., Xiao, L.F., Wang, Y., Chang, M., Tian, Y., Li, C., Zhang, Z., Song, S.*, Tong, W.M.*, Liu, P.*, and Niu, Y.* (2022). METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Report 41, 111530.

7 Lyu, C.#, Niu, Y.#, Lai, W., Wang, Y., Wang, Y., Dai, P., Ma, C., Chen, S., Li, Y., Jiang, G., Liang, Z., Ma, W., Gao, Z.*, Tong, W.M.*, and Wang, H.* (2022). Rare and misincorporated DNA N(6)-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells. Cell Discovery 8, 39.

8 Cai, Z., Zhang, Y., Yang, L., Ma, C., Fei, Y., Ding, J., Song, W., Tong, W.M.*, Niu, Y.*, and Li, H.* (2022). ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity. Cellular & Molecular Biology Letters 27, 101.

9 Wu, S.L.#, Zhang, X.#, Chang, M., Huang, C., Qian, J., Li, Q., Yuan, F., Sun, L., Yu, X., Cui, X., Jiang, J., Cui, M., Liu, Y., Wu, H.W., Liang, Z.Y., Wang, X., Niu, Y.*, Tong, W.M.*, and Jin, F.* (2021). Genome-wide 5-hydroxymethylcytosine profiling analysis identifies MAP7D1 as a novel regulator of lymph node metastasis in breast cancer. Genomics, Proteomics & Bioinformatics 19, 64-79.

10 Cai, Z., Niu, Y.*, and Li, H.* (2021). RNA N6-methyladenosine modification, spermatogenesis, and human male infertility. Molecular Human Reproduction 27(6):gaab020.

11 Ma, C.#, Chang, M.#, Lv, H.#, Zhang, Z.W., Zhang, W., He, X., Wu, G., Zhao, S., Zhang, Y., Wang, D., Teng, X., Liu, C., Li, Q., Klungland, A., Niu, Y.*, Song, S.*, and Tong, W.M.* (2018). RNA m(6)A methylation participates in regulation of postnatal development of the mouse cerebellum. Genome Biology 19, 68.

12 Chang, M.#, Lv, H.#, Zhang, W., Ma, C., He, X., Zhao, S., Zhang, Z.W., Zeng, Y.X., Song, S., Niu, Y.*, and Tong, W.M.* (2017). Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain. Open Biology 7, 170166.

13 Zheng, G.#, Dahl, J.A.#, Niu, Y.#, Fedorcsak, P., Huang, C.M., Li, C.J., Vågbø, C.B., Shi, Y., Wang, W.L., Song, S.H., Lu, Z., Bosmans, R.P., Dai, Q., Hao, Y.J., Yang, X., Zhao, W.M., Tong, W.M., Wang, X.J., Bogdan, F., Furu, K., Fu, Y., Jia, G., Zhao, X., Liu, J., Krokan, H.E., Klungland, A.*, Yang, Y.G.*, and He, C.* (2013). ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Molecular Cell 49, 18-29.

14 Niu, Y., Zhao, X., Wu, Y.S., Li, M.M., Wang, X.J., and Yang, Y.G.* (2013). N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics, Proteomics & Bioinformatics 11, 8-17.

课题组长：佟伟民 教授

课题组成员：牛亚梅 研究员

马春卉 助理研究员

李晴 研究助理

博士研究生：陈颜、许月思、李一凡、魏楠、肖灵凤、司徒晓华

硕士研究生：周诗翼