牛亚梅研究员的主要研究方向为：以临床重大生命健康问题为驱动、以发现新的早期诊断或治疗靶标为目标，分别从分子、细胞及整体实验动物水平切入系统性研究表观转录标记 RNA m6A 甲基化在肿瘤与神经退行性病变的发生过程中的功能与机制。致力于将基础科研与临床实践实现更好地契合与转化，以达到通过科研成果帮助临床医生解决实际问题的目的。 曾主持和参与多项国家自然科学基金、科技部、北自然以及院校级项目，在Molecular Cell, Cell Reports, Cell Discovery, Genome Biology, Cellular and Molecular Biology Letters, Genomics Proteomics Bioinformatics, Open Biology 等高水平杂志发表 SCI 论文 20 余篇，引用次数 3000 次以上。

1.Wu, S.L.#, Yang, L.#, Huang, C.#, Li, Q., Ma, C., Yuan, F., Zhou, Y., Wang, X.Y., Tong, W.M., Niu, Y.*, Jin, F.*. (2024) Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis. Clin Epigenetics. Accepted.

2. Lin, L., Ding, J., Liu, S., Liu, C., Li, Q., Gao, X., Niu, Y.*, Tong, W.M.*. (2024) Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Mol Neurobiol.doi: 10.1007/s12035-024-04301-6. Online ahead of print.

3.    Pan, W., Chen, Y., Xu, Y., Tong, W., and Niu, Y. (2024). RNA m6A methylation and Alzheimer’s Disease: current evidence and future perspectives. Human Brain 3(1)

4. Zhang, Z.W.#, Teng, X.#, Zhao, F.#, Ma, C.#, Zhang, J., Xiao, L.F., Wang, Y., Chang, M., Tian, Y., Li, C., Zhang, Z., Song, S.*, Tong, W.M.*, Liu, P.*, and Niu, Y.* (2022). METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Report 41, 111530.

5. Lyu, C.#, Niu, Y.#, Lai, W., Wang, Y., Wang, Y., Dai, P., Ma, C., Chen, S., Li, Y., Jiang, G., Liang, Z., Ma, W., Gao, Z.*, Tong, W.M.*, and Wang, H.* (2022). Rare and misincorporated DNA N(6)-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells. Cell Discovery 8, 39.

6. Cai, Z., Zhang, Y., Yang, L., Ma, C., Fei, Y., Ding, J., Song, W., Tong, W.M.*, Niu, Y.*, and Li, H.* (2022). ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity. Cellular & Molecular Biology Letters 27, 101.

7. Wu, S.L.#, Zhang, X.#, Chang, M., Huang, C., Qian, J., Li, Q., Yuan, F., Sun, L., Yu, X., Cui, X., Jiang, J., Cui, M., Liu, Y., Wu, H.W., Liang, Z.Y., Wang, X., Niu, Y.*, Tong, W.M.*, and Jin, F.* (2021). Genome-wide 5-hydroxymethylcytosine profiling analysis identifies MAP7D1 as a novel regulator of lymph node metastasis in breast cancer. Genomics, Proteomics & Bioinformatics 19, 64-79.

8. Cai, Z., Niu, Y.*, and Li, H.* (2021). RNA N6-methyladenosine modification, spermatogenesis, and human male infertility. Molecular Human Reproduction 27, gaab020

9. Yang, L., Wu, S., Ma, C., Song, S., Jin, F., Niu, Y.*, and Tong, W.M.* (2020). RNA m(6)A methylation regulators subclassify luminal subtype in breast cancer. Frontiers in Oncology 10, 611191.

10. Ma, C.#, Chang, M.#, Lv, H.#, Zhang, Z.W., Zhang, W., He, X., Wu, G., Zhao, S., Zhang, Y., Wang, D., Teng, X., Liu, C., Li, Q., Klungland, A., Niu, Y.*, Song, S.*, and Tong, W.M.* (2018). RNA m(6)A methylation participates in regulation of postnatal development of the mouse cerebellum. Genome Biology 19, 68.

11. Chang, M.#, Lv, H.#, Zhang, W., Ma, C., He, X., Zhao, S., Zhang, Z.W., Zeng, Y.X., Song, S., Niu, Y.*, and Tong, W.M.* (2017). Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain. Open Biology 7, 170166

12. Zheng, G.#, Dahl, J.A.#, Niu, Y.#, Fedorcsak, P., Huang, C.M., Li, C.J., Vågbø, C.B., Shi, Y., Wang, W.L., Song, S.H., Lu, Z., Bosmans, R.P., Dai, Q., Hao, Y.J., Yang, X., Zhao, W.M., Tong, W.M., Wang, X.J., Bogdan, F., Furu, K., Fu, Y., Jia, G., Zhao, X., Liu, J., Krokan, H.E., Klungland, A.*, Yang, Y.G.*, and He, C.* (2013). ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Molecular Cell 49, 18-29.

13.Niu, Y., Zhao, X., Wu, Y.S., Li, M.M., Wang, X.J., and Yang, Y.G.* (2013). N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics Proteomics & Bioinformatics 11, 8-17.