佟伟民教授的主要研究方向是上皮与神经元恶性转化的分子机制。利用临床样本及遗传工程修饰的小鼠，在整体、细胞和分子水平探讨DNA损伤、RNA修饰蛋白在上皮及神经源性肿瘤发生中的作用机制，为发现新的疾病干预及治疗方法提供理论基础。先后建立小鼠肝癌、乳腺癌、胰腺内分泌肿瘤，及小头畸形、神经变性病、神经源性肿瘤等小鼠模型。近年来，结合临床样本，在胰腺癌、乳腺癌、髓母细胞瘤、脑肌病，炎性脑病等肿瘤及神经变性病的研究中取得多项进展，发现多个潜在的治疗及诊断靶点，在 Brain Pathology, Cell Discovery，Cell Report，Cell Research，Genome Biology，Nature Cell Biology，Nature Medicine, Oncogene，DNA Repair，Cancer Research，American Journal of Pathology 等杂志共发表 SCI 论文 80 余篇。先后获人事部、教育部、科技部及国家自然科学基金等多项资助。

1. Lin, L., Ding, J., Liu, S., Liu, C., Li, Q., Gao, X., Niu, Y.*, Tong, W.M.*. (2024) Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Mol Neurobiol.doi: 10.1007/s12035-024-04301-6. Online ahead of print.

2. Liu, S.M., Li, M., Ma, C., Liu, C., Lv, A., Li, Q., Niu, Y., Wang, P., Huang, B., and Tong, W.M. (2024). HIV encephalopathy is contributed by macrophages and microglia. Sci China Life Sci. 67, 836-838.

3. Dong, T., Zhang, Z.Q., Sun, L.H., Zhang, W., Zhu, Z., Lin, L., Yang, L., Lv, A., Liu, C., Li, Q., Yang, R.F., Zhang, X., Niu, Y., Chen, H.Z., Liu, D.P.*, and Tong, W.M.* (2023). Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy. Brain Pathol, e13157.

4. Zhang, Z.W.#, Teng, X.#, Zhao, F.#, Ma, C.#, Zhang, J., Xiao, L.F., Wang, Y., Chang, M., Tian, Y., Li, C., Zhang, Z., Song, S*., Tong, W.M. *, Liu, P*., and Niu, Y.* (2022). METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep 41, 111530.

5. Wang, Z.#, Zhou, Y.#, Bao, L., Li, D., Lv, J., Wang, D., Li, S., Liu, J., Qin, C.*, Tong, W.M.*, and Huang, B.* (2022). Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages. Signal Transduct Target Ther 7, 116.

6. Lyu, C.#, Niu, Y.#, Lai, W., Wang, Y., Wang, Y., Dai, P., Ma, C., Chen, S., Li, Y., Jiang, G., Liang, Z., Ma, W., Gao, Z.*, Tong, W.M.*, and Wang, H.* (2022). Rare and misincorporated DNA N(6)-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells. Cell Discov 8, 39.

7. Gao, C.C.#, Li, M.#, Deng, W.#, Ma, C.H., Chen, Y.S., Sun, Y.Q., Du, T., Liu, Q.L., Li, W.J., Zhang, B., Sun, L., Liu, S.M., Li, F., Qi, F., Qu, Y., Ge, X., Liu, J., Wang, P., Niu, Y., Liang, Z., Zhao, Y.L., Huang, B., Peng, X.Z., Yang, Y.*, Qin, C.*, Tong, W.M.*, and Yang, Y.G.* (2022). Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques. Protein Cell 13, 920-939.

8. Wu, S.L.#, Zhang, X.#, Chang, M., Huang, C., Qian, J., Li, Q., Yuan, F., Sun, L., Yu, X., Cui, X., Jiang, J., Cui, M., Liu, Y., Wu, H.W., Liang, Z.Y., Wang, X., Niu, Y.*, Tong, W.M.*, and Jin, F.* (2021). Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer. Genomics Proteomics Bioinformatics 19, 64-79.

9. Ma, C.#, Chang, M.#, Lv, H.#, Zhang, Z.W., Zhang, W., He, X., Wu, G., Zhao, S., Zhang, Y., Wang, D., Teng, X., Liu, C., Li, Q., Klungland, A., Niu, Y.*, Song, S.*, and Tong, W.M.* (2018). RNA m(6)A methylation participates in regulation of postnatal development of the mouse cerebellum. Genome Biol 19, 68.

10. Chang, M.#, Lv, H.#, Zhang, W., Ma, C., He, X., Zhao, S., Zhang, Z.W., Zeng, Y.X., Song, S., Niu, Y.*, and Tong, W.M.* (2017). Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain. Open Biol 7.

11. Yang, H., Liu, P., Zhang, J., Peng, X., Lu, Z., Yu, S., Meng, Y., Tong, W.M.*, and Chen, J.* (2016). Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated by miR-193b. Oncogene 35, 3647-3657.

12. Li, R., Yang, Y.G., Gao, Y., Wang, Z.Q., and Tong, W.M.* (2012). A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell Res 22, 859-872.