"研究领域：大脑皮层是控制感知、学习、思维意识等高级神经功能的结构，其结构与功能异常会导致一系列神经精神疾病。我们主要围绕大脑皮层的发育与组装机制开展研究，特别是大脑皮层的层次结构及功能分区是如何有序产生的这一核心问题。另外我们也关注自闭症、先天性智力障碍等神经发育障碍疾病的发生机制。 主要成果：发现了一系列新的皮层发育相关的调控分子，提出了大脑皮层发育的“时序双梯度调控模型”，为哺乳动物大脑皮层发育模式提供了一些新的认识。相关成果以第一或通讯作者（含并列）发表在Dev Cell (2019)，EMBO J (2023), STTT (2024), PNAS (2019)，Cell Rep (2019)，eLife (2024), Cereb Cortex (2021, 2022)等学术期刊上。"

1. Xiao Liu#, Chaojuan Yang#, Zhuoran Lin#, Jianing Li#, Bin Yin, Xuepei Lei, Wei Han, Boqin Qiang, Pengcheng Shu*, Chen Zhang*, Xiaozhong Peng* (2024). DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis. Sci China Life Sci. https://doi.org/10.1007/s11427-023-2681-y (in press)

2. Yan Guo#, Pan Xiang#, Xiaojiao Sun, Wei Liu, Jiafeng Zhou, Bin Yin, Lin Hou, Boqin Qiang, Huiliang Li, Pengcheng Shu*, Xiaozhong Peng* (2024). Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther 9, 32. doi:10.1038/s41392-024-01742-2

3. Longjiang Xu#, Zan Yuan#, Jiafeng Zhou#, Yuan Zhao#, Wei Liu, Shuaiyao Lu, Zhanlong He, Boqin Qiang, Pengcheng Shu*, Yang Chen*, Xiaozhong Peng* (2024). Temporal transcriptomic dynamics in developing macaque neocortex. eLife. 12, doi: 10.7554/eLife.90325

4. Zhihua Ma#, Yi Zeng#, Ming Wang#, Wei Liu, Jiafeng Zhou, Chao Wu, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu*, Xiaozhong Peng*(2023). N4bp1 mediates RAM domain-dependent Notch signalling turnover during neocortical development. EMBO J. 42, e113383.

5. Jiafeng Zhou#, Gaoao Liu#, Xiaoling Zhang, Chao Wu, Mengjie Ma, Jiarui Wu, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu*, Xiaozhong Peng* (2022). Comparison of the Spatiotemporal Expression Patterns of Three Cre Lines, Emx1IRES-Cre, D6-Cre and hGFAP-Cre, commonly used in Neocortical Development Research. Cereb. Cortex 32, 1668-1681. doi: 10.1093/cercor/bhab305

6. Xiangbin Ruan, Gaoao Liu, Jiafeng Zhou, Pan Chen, Changjie Sun, Wei Liu, Chao Wu, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu*, Xiaozhong Peng* (2021). Zbed3 is indispensable for Wnt signaling regulation of cortical layers formation in developing brain. Cereb. Cortex 31, 4078-4091. doi: 10.1093/cercor/bhab070

7. Pan Xiang#, Fei Li#, Zhihua Ma, Jiping Yue, Cailing Lu, Yuangang You, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu*, Xiaozhong Peng*(2020). HCF-1 promotes cell cycle progression by regulating the expression of CDC42. Cell Death Dis 11, 907. doi:10.1038/s41419-020-03094-5.

8. Liang Li, Xiangbin Ruan, Chang Wen, Wei Liu, Pan Xiang, Pan Chen, Junjie Zhou, Chao Wu, Liyuan Zhu, Xiao Liu, Jianing Li, Xiaoling Zhang, Fei Li, Hanlu Li, Qunfang Wei, Lin Hou, Bin Yin, Jiangang Yuan, Boqin Qiang, Pengcheng Shu*, Xiaozhong Peng* (2019). The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signalling. Cell Rep 28 (3), 698-711 e695.

9. Xiao Liu#, Tai An#, Dongdong Li, Zheng Fan, Pan Xiang, Chen Li, Wenyi Ju, Jianing Li, Gen Hu, Bo Qin, Bin Yin, Justyna Aleksandra Wojdyla, Meitian Wang, Jiangang Yuan, Boqin Qiang, Pengcheng Shu*, Sheng Cui*, Xiaozhong Peng* (2019). Structure of heterophilic interaction between Nectin-like-4 and Nectin-like-1 molecules. Proc Natl Acad Sci U S A. 116, 2068-2077.

10. Chao Wu#, Xiaoling Zhang#, Pan Chen, Xiangbin Ruan, Wei Liu, Yanchao Li, Changjie Sun, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu*, Xiaozhong Peng*(2019). MicroRNA-129 modulates neuronal migration by targeting Fmr1 in the developing mouse cortex. Cell Death Dis 10, 287. doi: 10.1038/s41419-019-1517-1.

11. Pengcheng Shu#, Chao Wu#, Xiangbin Ruan, Wei Liu, Lin Hou, Hongye Fu, Ming Wang, Chang Liu, Yi Zeng, Bin Yin, Jiangang Yuan, Boqin Qiang, Xiaozhong Peng* and Weimin Zhong*(2019). Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Mammalian Neocortex. Dev Cell 49, 764-785 e764.

12. Pengcheng Shu#, Chao Wu#, Wei Liu#, Xiangbin Ruan#, Chang Liu, Lin Hou, Yi Zeng, Hongye Fu, Ming Wang, Pan Chen, Xiaoling Zhang, Bin Yin, Jiangang Yuan, Boqin Qiang, and Xiaozhong Peng* (2019). The spatiotemporal expression pattern of microRNA in the developing mouse nervous system. J Biol Chem. 294, 3444-3453.