黄波教授早年在国外的研究方向为肿瘤免疫逃逸，主要研究对象为髓样前体抑制细胞（myeloid derived suppressor cells）。黄波教授发现在荷瘤小鼠骨髓中大量表达一类髓样细胞，并发现此类细胞可以明显抑制T细胞的抗肿瘤免疫应答，进而促进肿瘤的进展，相关工作发表在Cancer research杂志上，现已被引用1200多次，同时原创性发现肿瘤细胞通过表达TLRs，介导肿瘤免疫逃逸，相关工作也在Cancer research上发表，现已被引用450多次。 目前实验室汇集肿瘤免疫、肿瘤代谢、肿瘤生物机械力信号、肿瘤囊泡等肿瘤的核心方面，还原肿瘤、T细胞及代谢的真实面目，实验室的主要研究方向包括：1、肿瘤免疫：机理上阐明肿瘤免疫相关的根本性科学问题；采用多种手段和模型研究肿瘤免疫、肿瘤免疫逃逸的细胞和分子机制；肿瘤微环境中细胞、分子成分与抗肿瘤治疗相关机制；以及肿瘤转移前微环境形成的细胞和分子机制；2、肿瘤免疫治疗：以肿瘤细胞来源的微颗粒（囊泡）为载体，携带化疗药物、溶瘤病毒对肿瘤进行治疗；以及对微颗粒的化疗增敏效应或者作为新型口服疫苗进行研究；微颗粒治疗恶性肿瘤患者胸腹水的临床前机制研究；从肿瘤患者外周血中分离出肿瘤特异性T细胞并进行体外扩增3、医学生物力学：探究生物力学对细胞增殖、分化的影响，从而揭示生物力学信号在生物体内发挥作用的机制；运用生物力学筛选肿瘤干细胞，对肿瘤发生发展进行研究以及探寻肿瘤治疗新思路新靶点；阐明干性肿瘤细胞的物理力学特征；4、T细胞基本生物学：T细胞的记忆、胸腺的萎缩、干性T细胞的扩增等；5、代谢：回答糖原代谢的本质、为什么需要脂肪酸氧化、自由基的调控等核心问题。 实验室自成立以来在相关领域发表通信作者SCI文章90余篇，包括Science、Science Immunology、Science Translational Medicine、Cancer Cell、Molecular Cell、Nature Materials、Nature Immunology（4篇）、Nature Cell Biology（3篇）、Nature Biomedical Engineering（2篇）等国际主流期刊， SCI引用次数8000余次。

1. Chen J, Zhou Y, Liu Z, Lu Y, Jiang Y, Cao K, Zhou N, Wang D, Zhang C, Zhou N, Shi K, Zhang L, Zhou L, Wang Z, Zhang H, Tang K, Ma J, Lv J, Huang B. Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG. Science. 2024 Feb 16;383(6684):eadi3332.

2. Ma J, Tang L, Tan Y, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K,  Zhang Y, Huang B. Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Jan 23.

3. Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X*, Huang B. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1. Nat Immunol. 2023 Dec;24(12):2042-2052.

4. Lv J, Zhou Y, Zhou N, Wang Z, Chen J, Chen H, Wang D, Zhou L, Wei K, Zhang H, Tang K, Ma J, Liu Y, Wan Y, Zhang Y, Zhang H, Huang B. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci Transl Med. 2023 Feb;15(681):eabq6024.

5. Tang K, Zhang H, Deng J, Wang D, Liu S, Lu S, Cui Q, Chen C, Liu J, Yang Y, Li Y, Chen J, Lv J, Ma J, Huang B.Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. Nat Immunol. 2023 Jan;24(1):162-173.

6. Zhang H, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Mol Cell. 2022 Jun 17:S1097-2765(22)00538-X.

7. Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72.

8. Liu Y, Zhou N, Zhou L, Dong B, Zhao Y, Yuan P, Gao Q, Zhang H, Xiao-Feng Qin F, Huang B. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor.Nat Immunol. 2021;22(3):358-69.

9. Zhang H, Tang K, Ma J, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

10. Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y*, Wang X*, Huang B. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020 Jul;4(7):743-53.

11. Liu Y,  Fang Y,  Chen X,  Wang Z,  Liang X,  Lv J,  Tang K,  Xie J,  Gao Y,  Cheng F,  Zhou Y,  Zhang Z,  Hu Y,  Zhang X,  Gao Q,  Zhang Y,  Huang B. Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 2020 Jan 17;5(43):eaax7969.

12. Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Qin FX, Huang B. Tumor repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480-494.

13. Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27.

14. Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N*, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater. 2012 Jul 1;11(8):734-41.