"课题组主要研究方向包括：gdT细胞在肿瘤的免疫监视中的作用及在抗肿瘤免疫治疗中的应用；神经退行性疾病的病理机制及神经系统与免疫系统之间相互调节的作用机制；诱导多能干细胞的定向分化、干细胞外泌体的改造及在疾病中的应用。主持和参加国家重大、重点科技项目和中美、中日、中德国际合作项目50余项，在国内外期刊发表论文和综述200余篇，主要研究成果发表在Cell，Nat Immunol，PNAS，Neuro Oncol，Blood，Cell Mol Immunol等知名杂志上。主编学术专著6部，授权发明专利10项，获得国家科技进步二等奖2项，省部级科技进步奖1项。 近年来课题组研究重心逐渐集中于临床转化应用研究上，与多家三甲医院合作，积极推进同种异体γδT细胞肿瘤过继免疫治疗的临床试验；另一方面，实现多项技术专利的转让，积极推动与企业的全面合作与融合，参与细胞治疗领域共性技术和先进关键技术的合作研发和临床转化。"

1)    Wang W, Xu Y, Wang L, Zhu Z, Aodeng S, Chen H, Cai M, Huang Z, Han J, Wang L, Lin Y, Hu Y, Zhou L, Wang X, Zha Y, Jiang W, Gao Z, He W, Lv W, Zhang J. Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis. Nat Immunol. 2022 Sep 22. doi: 10.1038/s41590-022-01312-0. Epub ahead of print. PMID: 36138182.

2)    Wang H, Chen H, Liu S, Zhang J, Lu H, Somasundaram R, Choi R, Zhang G, Ou L, Scholler J, Tian S, Dong L, Yeye G, Huang L, Connelly T, Li L, Huang A, Mitchell TC, Fan Y, June CH, Mills GB, Guo W, Herlyn M, Xu X. Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function. J Immunother Cancer. 2021 Dec;9(12):e003339. doi: 10.1136/jitc-2021-003339. PMID: 34937742; PMCID: PMC8705233.

3)    Chen H, Zhang J, He W. The role of microRNAs in γδ T cells: a long way to go. Cell Mol Immunol. 2021 Aug;18(8):2071-2072. doi: 10.1038/s41423-021-00711-x. Epub 2021 Jun 11. PMID: 34117372; PMCID: PMC8322083.

4)    You H, Dang G, Lu B, Zhang S, Li C, Wang L, Hu Y, Chen H, Zhang J, He W. Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome. J Clin Immunol. 2021 Apr;41(3):565-575. doi: 10.1007/s10875-020-00937-w. Epub 2021 Jan 3. PMID: 33392854; PMCID: PMC7921076.

5)    Fu Y, Wang D, Wang H, Cai M, Li C, Zhang X, Chen H, Hu Y, Zhang X, Ying M, He W, Zhang J. TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma. Neuro Oncol. 2020 Feb 20;22(2):240-252. doi: 10.1093/neuonc/noz183. PMID: 31563962; PMCID: PMC7442372.

6)    Zhu Y, Zhang S, Li Z, Wang H, Li Z, Hu Y, Chen H, Zhang X, Cui L, Zhang J, He W. miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity. Cell Mol Immunol. 2019 Feb;16(2):112-125. doi: 10.1038/cmi.2017.164. Epub 2018 Feb 12. PMID: 29429995; PMCID: PMC6355834.

7)    Chen H, Zou M, Teng D, Hu Y, Zhang J, He W. Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis. Cell Mol Immunol. 2019 Mar;16(3):250-259. doi: 10.1038/cmi.2017.157. Epub 2018 Feb 5. PMID: 30886423; PMCID: PMC6460488.

8)    Chen H, He W. Human regulatory γδT cells and their functional plasticity in the tumor microenvironment. Cell Mol Immunol. 2018 Apr;15(4):411-413. doi: 10.1038/cmi.2017.73. Epub 2017 Aug 28. PMID: 28845043; PMCID: PMC6052840.

9)    Mo WX, Yin SS, Chen H, Zhou C, Zhou JX, Zhao LD, Fei YY, Yang HX, Guo JB, Mao YJ, Huang LF, Zheng WJ, Zhang W, Zhang JM, He W, Zhang X. Chemotaxis of Vδ2 T cells to the joints contributes to the pathogenesis of rheumatoid arthritis. Ann Rheum Dis. 2017 Dec;76(12):2075-2084. doi: 10.1136/annrheumdis-2016-211069. Epub 2017 Sep 2. PMID: 28866647; PMCID: PMC5705844.

10)    Mao Y, Yin S, Zhang J, Hu Y, Huang B, Cui L, Kang N, He W. A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells. Cell Mol Immunol. 2016 Mar;13(2):217-28. doi: 10.1038/cmi.2015.07. Epub 2015 Mar 16. PMID: 25942601; PMCID: PMC4786628.

11)    Li Z, Jiao Y, Hu Y, Cui L, Chen D, Wu H, Zhang J, He W. Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection. Cell Mol Immunol. 2015 Sep;12(5):604-14. doi: 10.1038/cmi.2014.77. Epub 2014 Sep 15. PMID: 25220734; PMCID: PMC4579648.

12)    Zheng J, Guo Y, Ji X, Cui L, He W. A novel antibody-like TCRγδ-Ig fusion protein exhibits antitumor activity against human ovarian carcinoma. Cancer Lett. 2013 Dec 1;341(2):150-8. doi: 10.1016/j.canlet.2013.07.036. Epub 2013 Aug 3. PMID: 23920126.

13)    Dai Y, Chen H, Mo C, Cui L, He W. Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human γδ T cells to induce innate anti-tumor/virus immunity. J Biol Chem. 2012 May 11;287(20):16812-9. doi: 10.1074/jbc.M111.327650. Epub 2012 Mar 20. PMID: 22433851; PMCID: PMC3351303.

14)    Mo C, Dai Y, Kang N, Cui L, He W. Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways. J Biol Chem. 2012 Jun 1;287(23):19242-54. doi: 10.1074/jbc.M112.349936. Epub 2012 Apr 9. PMID: 22493490; PMCID: PMC3365956.

15)     Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell. 2011 Apr 15;145(2):284-99. doi: 10.1016/j.cell.2011.03.016. PMID: 21496646; PMCID: PMC3085003.

16)    Li X, Kang N, Zhang X, Dong X, Wei W, Cui L, Ba D, He W. Generation of human regulatory gammadelta T cells by TCRgammadelta stimulation in the presence of TGF-beta and their involvement in the pathogenesis of systemic lupus erythematosus. J Immunol. 2011 Jun 15;186(12):6693-700. doi: 10.4049/jimmunol.1002776. Epub 2011 May 11. PMID: 21562160.

17)    He X, Chen H, Wu D, Cui L, He W. Tandem-epitope peptide: a novel stimulator for gammadeltaT cells in tumor immunotherapy. Cancer Lett. 2010 Feb 1;288(1):86-93. doi: 10.1016/j.canlet.2009.06.024. Epub 2009 Aug 7. PMID: 19665289.

18)    Kong Y, Cao W, Xi X, Ma C, Cui L, He W. The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D. Blood. 2009 Jul 9;114(2):310-7. doi: 10.1182/blood-2008-12-196287. Epub 2009 May 12. PMID: 19436053.

19)    Yu M, Wan M, Zhang J, Wu J, Khatri R, Chi T. Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3873-8. doi: 10.1073/pnas.0800810105. Epub 2008 Mar 5. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6502. PMID: 18322012; PMCID: PMC2268827.

何维教授，德国海德堡大学医学博士。中国医学科学院基础医学研究所，北京协和医学院免疫学系主任，教授，博士生导师。中国农工民主党党员，中国农工民主党十五届中央专职副主席，中国人民政治协商会议第十二届全国委员会副秘书长、常务委员。