"课题组围绕RNA代谢与造血调控，从RNA代谢角度解析干细胞命运转变、造血发育分化、疾病发生发展的基本规律，发掘RNA分子的新功能，鉴定RNA代谢的新机制，探索通过干预RNA代谢进行疾病治疗的新方法，并开展疾病的RNA治疗。近年来，取得多项重要发现，相关工作以通讯/第一作者在Cell Stem Cell、Developmental Cell、Blood、EMBO J（2015, 2020）、Nature Communications、Genome Research、Stem Cell Reports 等学术期刊发表，曾获教育部自然科学二等奖。获国家优秀青年基金（2021）、北京市“科技新星” （2017）、中国医学科学院“青年医学人才奖励项目”（2018）、“协和新星” （2015）等人才计划支持。 近年来，在相关领域取得多项重要发现： 1. RNA代谢与造血调控 利用单细胞测序技术绘制出造血干细胞发育全程的lncRNA图谱，揭示了调控“内皮-造血”转换的关键lncRNA（Cell Stem Cell 2019），文章发表后被Faculty 1000推荐阅读；同时首次描绘了成体造血干细胞分化层级的RNA编辑图谱，并从中鉴定了调控造血干细胞分化的关键编辑事件（Blood 2021）；通过系统性调查假基因的表达特征及与疾病的关联，发现假基因HBBP1演化出调控人红细胞发育及疾病的重要作用及全新机制（Developmental Cell 2021）。 2. RNA代谢与干细胞命运 系统性揭示了RNA结合蛋白在胚胎干细胞多能性退出中的作用，发现hnRNPLL通过调控mRNA可变剪接促进胚胎干细胞退出多能性（EMBO J 2021）；发现系列microRNA可协同转录因子调控造血干细胞及胚胎干细胞分化（EMBO J 2015）；描绘了多能干细胞向造血所在中胚层分化过程RNA定位的动态图谱及规律（Stem Cell Reports 2024）；揭示了假基因在人类早期胚胎发育过程中的潜在功能（J Genet Genomics 2024）。 3. RNA代谢与血液疾病 揭示了RNA代谢在血液疾病发生发展中的作用，鉴定了新的潜在治疗靶点；建立了正常血细胞及白血病细胞的RNA编辑数据库REDH（Chin Med J 2024）；发现假基因HBBP1可通过提高TAL1 表达参与促进β-地中海贫血患者中胎儿血红蛋白水平升高，减轻了地贫患者的贫血症状（Developmental Cell 2021）。 "

1. Mengyao Sun†, Le Chang†, Liu He, Li Wang, Zhengyang Jiang, Yanmin Si, Jia Yu, Yanni Ma*. Combining single-cell profiling and functional analysis explores the role of pseudogenes in human early embryonic development. J Genet Genomics. 2024 Jul 18:S1673-8527(24)00189-9.

2. Xu J†, He J†, Yang J†, Wang F, Huo Y, Guo Y, Si Y, Gao Y, Wang F, Cheng H, Cheng T, Yu J, Wang X, Ma Y*. REDH: A database of RNA editome in hematopoietic differentiation and malignancy. Chin Med J (Engl). 2024 Feb 5;137(3):283-293.

3. Zhou F†, Tan P†, Liu S, Chang L, Yang J, Sun M, Guo Y, Si Y, Wang D, Yu J, Ma Y*. Subcellular RNA distribution and its change during human embryonic stem cell differentiation. Stem Cell Reports. 2024 Jan 9;19(1):126-140.

4. Yanni Ma*, Zhongyang Chen, Jia Yu*. Pseudogenes and their potential functions in hematopoiesis. Experimental Hematology. 2021 Nov;103:24-29.

5. Fengjiao Wang†, Jiahuan He†, Siqi Liu†, Ai Gao, Liu Yang, Guohuan Sun, Wanqiu Ding, Chuanyun Li, Fanglin Gou, Manman He, Fang Wang, Xiaoshuang Wang, Xiangnan Zhao, Ping Zhu, Shao Hao, Yanni Ma*, Hui Cheng*, Jia Yu*, Tao Cheng*. Comprehensive RNA editome reveals edited Azin1 as a novel DDX1 partner to facilitate hematopoietic stem cell differentiation. Blood. 2021 Nov 18;138(20):1939-1952.

6. Yanni Ma†*, Siqi Liu†, Jie Gao†, Chunyan Chen†, Xin Zhang†, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Feb 22;56(4):478-493.e11.56(4):478–493.e11.

7. Xue Wang†, Changyun Ping†, Puwen Tan†, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729.

8. Kai Li†, Jiayue Xu†, Yanyun Luo†, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.

9. Jie Zhou†, Jiayue Xu†, Lingling Zhang†, Siqi Liu†, Yanni Ma†, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2):285-298.e5.

10. Yanni Ma†, Nan Yao†, Guang Liu†, Lei Dong, Fang Wang, Bin Wang, He Dong, Xueju Wei, Meili Zhang, Shaowei Ji, Yufang Liu, Junwu Zhang, Yangming Wang, Yue Huang*,Jia Yu*. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cell. The EMBO Journal. 2015 Feb 3. 34(3):361–378.

11. Yanni Ma†, Bin Wang†, Fengbing Jiang†, Dongsheng Wang†, Huiwen Liu, Yunmeng Yan, He Dong, Fang Wang, Bei Gong, Yong Zhu, Lei Dong, Haixin Yin, Zhongzu Zhang, Hualu Zhao, Zhikui Wu, Junwu Zhang, Jingguo Zhou, Jia Yu*. A Feedback Loop Consisting of MicroRNA 23a/27a and the Beta-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression. Molecular and Cellular Biology.2013 Oct; 33(20):3994-4007.