目前研究方向为转录后调控与造血发育及血液系统疾病。

在研项目：

1.   科技部国家重点研发计划干细胞专项，2022-2026、造血发育及再生的翻译调控研究、主持。

2.   国家优秀青年科学基金，2021-2023、造血分化调控、主持。

3.   国家自然科学基金委面上项目，2020-2023、miRNA初级转录本作为新型lncRNA调节造血红系分化的功能和机制研究、主持。

代表性论著 († first author; * corresponding author):

1.Qing You†, Fang Wang†, Rong Du, Jingnan Pi, Huayi Wang, Yue Huo, Jingyi Liu, Chen Wang, Jia Yu*, Yanlian Yang*, Ling Zhu*. m6A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation. Adv Mater. 2022 Dec 9:e2204910.

2.Xueju Wei†, Yue Huo†, Jingnan Pi†, Yufeng Gao†, Shuan Rao†, Manman He†, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nature Cell Biology. 2022 Aug. 24(8):1278-1290.

3.Fang Wang†, Puwen Tan†, Pengcheng Zhang†, Yue Ren†, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7. 8(1):eabg5369.

4.Yue Ren†, Yue Huo†, Weiqian Li†, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. Nuclear fractionation reveals chromatin-enriched RNA-binding proteins and transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14. 22(1):290.

5.Jingnan Pi†, Wen Wang†, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10): 2651-2665.

6.Yan Huang†, Puwen Tan, Xiaoshuang Wang, Ying Yi, Yongfei Hu, Dong Wang, Wang F*. Transcriptomic insights into temporal expression pattern of autophage genes during monocytic and granulocytic differentiation. Autophagy. 2018 Feb 21. 14(3):558-559.

7.Hongmei Zhao†, Xiaoshuang Wang†, Ping Yi†, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428.

8.Fang Wang†, Wei Song†, Hongmei Zhao†, Yanni Ma, Yuxia Li, Di Zhai, JingnanPi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar. 27(3):416-439.

9.Rui Su†, Lei Dong†, Dongling Zou, Hongmei Zhao, Yue Ren, Feng Li, Ping Yi, Lanfang Li, Yong Zhu, Yanni Ma, Jing Wang, Fang Wang*, Jia Yu*. MicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Nov 17. 35(46):6001-6014.

10.Lanfang Li†, Qingya Luo, Zhe Xie, Guiqin Li, Chengyi Mao, Yi Liu, Xin Wen, Na Yin, Jianzhong Cao, Jing Wang, Li Li, Jianhua Yu, Fang Wang*, Ping Yi*. Characterization of the expression of the RNA binding protein eIF4G1 and its clinicopathological correlation with serous ovarian cancer. PLoS One. 2016 Sep 26. 11(9):e0163447.

11.Peng-Fei Zhai†, Fang Wang†, Rui Su, Hai-Shuang Lin, Chong-Liang Jiang, Gui-Hua Yang, Jia Yu, Jun-Wu Zhang*. The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis. J Biol Chem. 2014 Aug 15. 289(33):22600-13.

12.Yuxia Li, Hua Bai, Zhongzu Zhang, Weihua Li, Lei Dong, Xueju Wei, Yanni Ma, Junwu Zhang, Jia Yu, Guotao Sun*, Fang Wang*. The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2. Mol. Cells. 2014 Mar. 37(3):1-7.

13.Fang Wang†, Yong Zhu†, Lihua Guo†, Lei Dong, Huiwen Liu, Haixin Yin, Zhongzu Zhang, Yuxia Li, Changzheng Liu, Yanni Ma, Wei Song, Aibin He, Qiang Wang, Linfang Wang, Junwu Zhang, Jianxiong Li, Jia Yu*. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Research. 2014 Jan. 42(1):442-57.

14.Yong Zhu†, Dongsheng Wang†, Fang Wang†, Tingting Li, Lei Dong, Huiwen Liu, Yanni Ma, Fengbing Jiang, Haixin Yin, Wenting Yan, Ming Luo, Z Tang, Guoyuan Zhang, Qiang Wang, Junwu Zhang, Jingguo Zhou, Jia Yu*. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Research. 2013 Apr. 41(7):4129-43.

15.Fang Wang†, Xiao-Shuang Wang, Gui-Hua Yang, Peng-Fei Zhai, Peng-Fei Zhai, Zhen Xiao, Liang-Yu Xia, Li-Rong Chen, Yu Wang, Xiao-Zhong Wang, Lai-Xi Bi, Nian Liu, Yang Yu, Da Gao, Bin-Tao Huang, Jing Wang, Dao-Bin Zhou, Jia-Nan Gong, Hua-Lu Zhao, Xiu-Hua Bi, Jia Yu, Jun-Wu Zhang*. miR-29a and miR-142-3p downregulation and diagnostic implication in human acute myeloid leukemia. Mol Biol Rep. 2012 Mar. 39(3):2713-22.

16.Fang Wang†, Jia Yu, Guihua Yang, Xiaoshuang Wang, Junwu Zhang*. Regulation of erythroid differentiation by miR-376a and its targets. Cell Research. 2011 Aug. 21(8): 1196-209.

17.Jin-Yun Yuan†, Fang Wang†, Jia Yu†, Gui-Hua Yang,Xiao-Ling Liu, Jun-Wu Zhang*. MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells. J. Cell. Mol. Med. Nov-Dec 2009. 13(11-12):4551-9.

18.Jia Yu†, Fang Wang†, Gui-Hua Yang, Fan-Long Wang, Yan-Ni Ma, Zhan-Wen Du, Jun-Wu Zhang*. Human miRNA Clusters: genomic organization and expression profile in leukemia cell lines. Biochem Biophy Res Commun. 2006 Oct 13. 349(1):59-68.

王芳，女，1983年2月生，教授，博士生导师。2009年毕业于北京协和医学院，获博士学位，后留所工作至今。2012年晋升副教授，2017年晋升教授，同年获聘博士生导师。作为负责人承担国家自然科学基金委青年、面上项目，作为科研骨干参与科技部973项目，国家重点研发计划。获科技部重点研发计划”青年科学家项目” (2022)、国家“优秀青年科学基金”（2021）、医科院“青年医学人才奖励项目”（2018）、 “协和新星” (2016)等人才计划支持。作为第一作者或通讯作者（含共同）在Nature Cell Biology、Cell Research、Nature Communications、Genome Biology、 Cancer Research、Nucleic Acids Research、Autophagy、Oncogene、JBC等国际学术期刊发表SCI论文20篇。获教育部自然科学二等奖（2018）。