本课题组在二十世纪九十年代我国人类基因组计划启动时，应用差异显示RT-PCR和比较蛋白质组学等分析技术，从不同发育阶段的胎脑及分化前后的神经系统肿瘤细胞中分离、克隆到一批新的在神经细胞不同发育或分化阶段高表达或特异表达编码基因的全长cDNA。在建立了比较系统的基因结构与功能研究体系的基础上近几年对其中部分基因及其编码的蛋白质开展了比较系统的结构与功能研究，初步揭示了这些基因的生物学功能及发挥生物学功能的分子机制。 近年来实验室主要研究方向为神经发育和疾病发生的分子机理研究，从基因表达调控的多个层次上系统研究神经系统发育过程中神经细胞增殖、分化的调控机制和神经系统疾病发生的细胞分子机理,为脑发育以及脑重大疾病的预警、诊断和治疗提供理论基础。 研究方向: 神经发育和神经系统疾病的分子机理研究 目前课题组在研的部分科研项目： 国家重点研发计划 2016YFA0100702 国家重点研发计划 2016YFC0902502 国家自然基金 31670789 国家自然基金 31671115

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2.       Yang B, Hu P, Lin X, Han W, Zhu L, Tan X, Ye F, Wang G, Wu F, Yin B, Bao Z,Jiang T, Yuan J, Qiang B, Peng X. PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas. Cell Mol Life Sci. 2015 Nov;72(22):4383-97.

3.       Yang B, Wang S, Zeng J, Zhang Y, Ruan X, Han W, Yin B, Yuan J, Qiang B, Ying W, Qian X, Peng X. Proteomic screening and identification of microRNA-128 targets in glioma cells. Proteomics. 2015 Aug; 15(15):2602-17.

4.       Han W, Xin Z, Zhao Z, Bao W, Lin X, Yin B, Zhao J, Yuan J, Qiang B, Peng X.RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3. J Clin Invest. 2013 May 1; 123(5):2103-18.

5.       Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, Qiang B, Yuan J, Peng X. MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging. 2012 March，33（3）522-534.

6.       Tan X, Wang S, Zhu L, Wu C, Yin B, Zhao J, Yuan J, Qiang B, Peng X. cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39): 15805-10.

7.       Li W, Shi L, You Y, Gong Y, Yin B, Yuan J, Peng X. Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons. BMC Biol. 2010 Jun 18;8:86.

8.       Wen J, Xia Q, Wang C, Liu W, Chen Y, Gao J, Gong Y, Yin B, Ke Y, Qiang B, Yuan J, Peng X. Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway. J Mol Cell Cardiol. 2009 Dec;47(6):761-9.

9.       Jing Gao, Tao Chen, Jin Liu, Wei Liu, Jizong Zhao, Guangyu Hu,Bin Yin, Yanhua Gong, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor- Trichostatin A through Sp1 binding site. Glia. 2009 Jul;57(9):989-99.

10.   Yu Zhang, Tengfei Cha, , Ran Li , Yang Chen, Xingqi Yan,Yanhua Gong, Bin Yin, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3. J Mol Med. 2009 Jan;87(1):43-51.

11.   Jinsil Park,Ben Liu,Tao Chen,Hong Li, Xuemei Hu,Jing Gao,Ying Zhu, Qiang Zhu, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng,and Mengsheng Qiu .Disruption of Nectin-Like 1 Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS. J Neurosci. 2008 Nov 26;28(48):12815-9.

12.   Fengwei Tan , Lifang Lu , Yun Cai, Jinglan Wang, Lin Wang, Yanhua Gong , Bing-e Xu, Jun Wu, Ying Luo, Boqin Qiang, Jiangang Yuan, Xiaoqing Sun, and Xiaozhong Peng. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. Proteomics. 2008 Jul;8(14):2885-96.

13.   Xudong Wu, Yanhua Gong, Jiping Yue, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng .NSPc1-mediated histone H2A ubiquitination and DNA methylation cooperate in HOX gene silencing. Nucleic Acids Res 2008 Jun;36(11):3590-9.

14.   Yanhua Gong, Jiping Yue, Xudong Wu, Xu Wang, Jianyan Wen, Lifang Lu, Xiaozhong Peng, Boqin Qiang & Jiangang Yuan. NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE. Nucleic Acids Res. 2006;34(21):6158-69

15.   Xiuhua Dong, Feng Xu, Jing Gao, Tao Chen, Peng Lin, Yanhua Gong, Ying Peng, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng & Zihe Rao . Crystal structure of the N-terminal domain of human Nectin-like molecule-1/SynCAM3/TSLL1/IGSF4B, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. J Biol Chem. 2006 Feb 7; 14;281(15):10610-7.

16.   Chunyu Han, Hao Liu, Jin Liu, Kang Yin, Yi Xie, Xiao Shen, Yong Wang, Jiangang Yuan,Boqing Qiang, Yong-Jian Liu and Xiaozhong Peng. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. Nucleic Acids Res. 2005, 33( 20) 6555-6565.

17.   Ning Shi，Sheng Ye，Mark Bartlam，Maojun Yang，Jin Wu，Yiwei Liu，Fei Sun，Xueqing Han，Xiaozhong Peng，Boqin Qiang，Jiangang Yuan，Zihe Rao：Structural basis for the specific recognition of RET by the Dok1 PTB domain. J Biol Chem. ,2004,279(6):4962-9

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彭小忠研究员，现任课题组组长。1983-1988年毕业于中南大学湘雅医学院（湖南医科大学）临床医学系并获医学学士学位。1988-1991年任中国医学科学院医学生物学研究所生物化学与分子生物学研究室实习研究员。1996年就读于中国协和医科大学微生物学专业并获理学博士学位。1996-2000年在美国纽约州立大学石溪分校微生物学和分子遗传学系做博士后。2000年至今任中国医学科学院基础医学研究所生物化学与分子生物学系副研究员、研究员并先后任硕、博士生导师。2007年入选教育部新世纪人才支持计划，并担任“发育与生殖研究”重大科学研究计划项目“非编码RNA在神经和肌肉早期发育过程中的功能研究及其体内示踪的研究”项目首席科学家。2008年获国家杰出青年科学基金项目资助。2010年获“协和学者”特聘教授称号。2013年入选国家百千万人才工程，并被授予“有突出贡献中青年专家”荣誉称号。现任中国医学科学院医学灵长类动物研究中心主任,中国医学科学院医学生物学研究所常务副所长。