王晨轩，研究员，博士生导师。1986年生于北京。中国医学科学院基础医学研究所/北京协和医学院基础学院，生物物理与结构生物学系课题组长，院校准长聘教职系列。在Sci Adv, Nat Comm, PNAS, JACS等国际期刊上发表论文70余篇，获得国家专利授权18项。当前研究方向为疾病相关蛋白质折叠、组装、相变与调控。课题组隶属于重大疾病共性机制研究全国重点实验室。实验室有副研究员2人，博士与硕士研究生10人。主讲八年制与研究生课《生物物理学》，参与《纳米医学概论》、《化学生物学》、《生理学的物理分析》等研究生课教学任务。主持国家自然科学基金面上项目、青年项目、北京自然科学基金面上项目、中国医学科学院医学健康前沿交叉研究项目，作为任务负责人参与国自然重大研究计划集成项目。中国生物物理学会纳米生物学分会委员，中国生物物理学会纳米生物学分会优秀青年学者（2023年）。

联系方式

Email：wangcx@ibms.pumc.edu.cn

 

教育及工作经历

2004-2008年，兰州大学国家理科化学基地班，本科。

2008-2013年，中国科学院国家纳米科学中心与清华大学化学系联合培养研究生，物理化学专业。导师王琛研究员、杨延莲研究员、李艳梅教授。研究方向：淀粉样蛋白折叠结构的研究及多肽-药物相互作用。2013年获清华大学理学博士学位。

2010年，丹麦奥胡斯大学多学科交叉纳米中心访问学者，合作导师董明东教授。

2013-2018年，美国威斯康星大学麦迪逊校区化学系，化学与生物工程系博士后。合作导师美国工程院院士Nicholas L. Abbott教授，美国科学院院士Samuel H. Gellman教授。研究方向：多肽折叠结构与单分子力学研究。

2018至今，中国医学科学院基础医学研究所/北京协和医学院基础学院生物物理与结构生物学系，课题组长。历任副研究员、硕士生导师、研究员、博士生导师。

研究方向：疾病相关蛋白质组装与调控

蛋白质的正确折叠与组装是维持人体生理机能的必需。肽链通过精密地调控分子间相互作用自组装形成有序三维分子结构，进一步组装、聚集、相分离，形成执行生理功能的分子机器与无膜细胞器。蛋白质组装稳态失衡是一系列退行性疾病共同的病理生理基础。研究蛋白质组装过程与结构，认识自组装过程中的分子间相互作用的本质与规律，实现对自组装过程与功能的有效调控对蛋白质组装相关疾病的预防和治疗有重要意义，从经典药物治疗到相关新型药物治疗的兴起，从微观层面对发病分子机理的阐述到宏观层面治疗模式的创新，新的认识将在未来改变相关疾病的诊治模式，为患者改善预后带来新的机遇。课题组遵循“认识组装-调控组装-利用组装”的研究思路，发展扫描隧道显微术、核磁共振波谱技术等新颖的物理、物理化学方法用于生物大分子的结构测定，理解与重大疾病发生、发展密切相关的蛋白、多肽的折叠、组装结构和过程，认识蛋白、多肽折叠组装过程中的相互作用本质与调控规律。

 

（1）建立非晶态聚集体的非平均化结构解析方法，揭示病理性聚集体的“构象群效应”。

经典结构解析技术依赖大量分子平均化处理，适用于表征高有序性的晶态聚集体结构。然而，多种疾病相关聚集体广泛存在结构高度异质、低有序性的非晶态组分，其在毒理过程中发挥重要作用，却长期缺乏高分辨结构信息。团队将原子尺度逐点成像的扫描隧道显微术结合统计热力学建模，引入Python 语言开发图像定量分析算法用于图像特征识别与重构，建立适用于非晶态聚集体结构解析的PI-3S方法。在聚集体内部识别出超过10种动态共存构象及逾90种异构相互作用网络，首次发现病理性聚集体的“构象群效应”（Sci Adv, 2023, 9(27), eadg794）。开发基于二维短时傅里叶变换的新方法，实现对b-片层有序度的空间分辨定量分析及空间频率分布解析，发现非晶态聚集体特有的“跨b-片层楔钉榫”构象，揭示这种新颖构象在维持病理性聚集体构象群结构稳定性中发挥的关键作用（Nat Commun, 2026, 17(1):1449）。

 

(2) 解析病理性聚集体的构象群异质性的形成与调控规律，原创性构建“构象群混沌理论”

非晶态聚集体的“构象群效应”从根本上突破了经典的“序列决定单一结构”蛋白质折叠理论框架。团队原创性构建“构象群混沌理论”框架，系统阐明：（1）整体性：构象群异质性受关键位点调控，其整体的结构变化（而非单一构象）与疾病表型相关（ACS Cent Sci, 2023, 9(7), 1480–1487; Nano Lett, 2025, 25(24), 9677−9685）；（2）混沌性：构象群对初始条件（如单体构象、局部微环境）敏感，其细微差异可被非线性放大，导致聚集路径分化成各异的构象群（J Am Chem Soc, 2025, 147(37), 33507-33517；Nano Lett, 2023, 23(6), 2370-2378）；（3）边界性：虽然单一构象的演变轨迹具有混沌性特征，难以预测（Mater Today Phys, 2024, 44, 101437），但构象群的整体行为仍被严格限制在由氨基酸序列和基本物理规则所决定的边界之内（ACS Cent Sci, 2025, 11(6), 927–937）。上述进展突破了奠基于“阿芬森假说”的静态结构生物学范式，建立了整体性调控、混沌演化、演化边界受限的理论框架。

 

(3) 病理性聚集体的亲和肽/分子发现及其作用机制解析

围绕一系列病理性聚集体，开发靶向分子。结合临床样本，首次阐明半乳糖凝素-10（Gal-10）通过形成具有不同构象特征的晶态/非晶态聚集体，驱动差异化免疫应答，促进2型免疫疾病的病理发生机制（Nano Lett, 2022, 22, 2350-2357）。为突破Gal10单抗药物临床失败困境，开发干预其聚集多态性的多肽（ACS Appl Mater Interf, 2025, 17, 8949-8961），发现传统降糖药二甲双胍在该疾病中的“老药新用”潜力（Nano Today, 2026, 68, 103017）。开发Gal10靶向肽组装成非晶态聚集体，兼具抗体级亲和力与更优的稳定性、环境适应性（J Am Chem Soc, 2026, 148, 11843-11856）。

课题组历年发表论文

2026 Publications

77. Wenbo Zhang#, Zhenyan Li#, Hongwei Li, Zhun Deng, Shuyuan Li, Ruonan Wang, Zhongyi Jian, Zhenlin Liu, Chenxuan Wang*, Mutational effects on conformational plasticity redirect the aggregation pathways of intrinsically disordered peptides. Nano Today, 2026, 69, 103044. DOI: 10.1016/j.nantod.2026.103044.

76. Shanshan Mo#, Lanlan Yu#, Xiaolu Li#, Wenbo Zhang, Shuyuan Li, Yun Hao, Shuang Yao, Zhenyan Li, Yang Wang, Longxin Xu, Ruonan Wang, Zhun Deng, Xiangdong Wang, Yan Zhao*, Chenxuan Wang*, Luo Zhang*，Structurally resilient peptide assembly regulates pathogenic galectin-10 crystallization to mitigate crystallopathy inflammation. Journal of the American Chemical Society, 2026, 148(11), 11843–11856. DOI: 10.1021/jacs.5c21181.

75. Wenbo Zhang#, Shuyuan Li#, Yang Wang#, Xin Wang, Shanshan Mo, Longxin Xu, Zhongyi Jian, Shuli Liu, Zhenlin Liu, Yanlian Yang, Chen Wang, Yuxing Yao, Xiaoping Bao, Lanlan Yu*, Xiaoguang Wang*, Chenxuan Wang*, Inspired by ion-specific effects: repurposing metformin to tackle protein crystallopathy. Nano Today, 2026, 68, 103017. DOI: 10.1016/j.nantod.2026.103017.

74. Shanshan Mo#, Ruonan Wang#, Zhongyi Jian, Mingwei Liu, Feiyi Zhang, Zhun Deng, Wenbo Zhang, Yanlian Yang, Chen Wang, Lanlan Yu*, Mingzhan Wang*, Chenxuan Wang*, Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates, Nature Communications, 2026, 17(1), 1449. DOI: 10.1038/s41467-025-68185-3.

2025 Publications

73. Mingrui Chen#, Zhongyi Jian#, Mingzhan Wang#, Zhenlin Liu, Yanlian Yang, Chen Wang, Lanlan Yu*, Wenbo Zhang*, Chenxuan Wang*, Beyond the amyloid core: modulation of aggregate conformational diversity by mutations in the noncore regions, Journal of the American Chemical Society, 2025, 147(37), 33507-33517. DOI: 10.1021/jacs.5c07880.

72. Zhun Deng#, Zhongyi Jian#, Mingzhan Wang#, Ruonan Wang, Shanshan Mo, Wenbo Zhang, Yanlian Yang, Chen Wang, Lanlan Yu*, Chenxuan Wang*, Submolecular resolution imaging of amyloid aggregation: an STM approach to decipher missense mutation effects in α‑synuclein, Nano Letters, 2025, 25(24), 9677−9685. DOI: 10.1021/acs.nanolett.5c01672.

71. Ruonan Wang#, Zhongyi Jian#, Yanlian Yang, Chen Wang, Lanlan Yu*, Mingzhan Wang*, Chenxuan Wang*, Submolecular resolution of β‑sheet plasticity: decoding mutations and PTMs in protein aggregation disorders. ACS Central Science, 2025, 11(6), 927–937, DOI: 10.1021/acscentsci.5c00421.

70. Wenbo Zhang#, Shuyuan Li#, Yang Wang#, Shuli Liu#, Lei Liu, Zhun Deng, Shanshan Mo, Mingrui Chen, Zhenyan Li, Ruonan Wang, Xin Zhou, Longxin Xu, Lanlan Yu, Zhenlin Liu, Hongwei Li*, Junbo Liang*, Chenxuan Wang*, Arginine-rich peptides regulate the pathogenic galectin-10 crystallization and mitigate crystallopathy-associated inflammation. ACS Applied Material Interfaces, 2025, 17(6), 8949−8961, DOI: 10.1021/acsami.4c18411.

69. 刘明巍, 陈明锐, 王晨轩, 张文博*, 单点氨基酸突变调控白内障相关人gC晶状体蛋白结构的热稳定性. 基础医学与临床, 2025, 45 (11), 1415-1419. doi: 10.16352/j.issn.1001-6325.2025.11.1415

68. 周鑫, 李珍艳, 李淑媛, 张文博*, 王晨轩, 白内障相关人gＤ晶状体蛋白的热诱导变性. 基础医学与临床, 2025, 45(1), 1-6. doi: 10.16352/j.issn.1001-6325.2025.01.0001

67. 王若楠#, 简中意#, 于兰兰*, 王晨轩*, 翻译后修饰调控神经退行性疾病相关蛋白质聚集体的构象多态性研究. 中国科学：化学, 2025, 55(4), 785-807，DOI: 10.1360/SSC-2024-0194.

2024 Publications

66. Shuli Liu#, Ruonan Wang#, Xuejing Wang#, Lanlan Yu*, Chenxuan Wang*, Composition effects on the self-aggregation of phenylalanine-rich oligopeptides revealed by atomic force microscopy, Colloid and Polymer Science, 2024, 302 (10), 1701-1709, DOI: 10.1007/s00396-024-05300-8.

65. Ye Yuan#, Lei Chen, Kexu Song, Miaomiao Cheng, Ling Fang, Lingfei Kong, Lanlan Yu, Ruonan Wang, Zhendong Fu, Minmin Sun, Qian Wang, Chengjun Cui, Haojue Wang, Jiuyang He, Xiaonan Wang, Yuan Liu, Bing Jiang, Jing Jiang, Chenxuan Wang, Xiyun Yan, Xinzheng Zhang, Lizeng Gao*, Stable peptide-assembled nanozyme mimicking dual antifungal actions, Nature Communications, 2024, 15, 5636, DOI: 10.1038/s41467-024-50094-6.

64. Zhongyi Jian#, Ruonan Wang#, Shanshan Mo, Zhun Deng, Shuyuan Li, Zhenyan Li, Mingzhan Wang, Yanlian Yang, Chen Wang, Wenbo Zhang, Lanlan Yu*, Chenxuan Wang*, Structural evolution of the conformational ensembles in peptide fibrillar aggregates, Materials Today Physics, 2024, 44, 101437, DOI: 10.1016/j.mtphys.2024.101437.

2023 Publications

63. Wenbo Zhang#, Ruonan Wang#, Mingwei Liu#, Shucong Li, Asher E. Vokoun, Weichen Deng, Robert L. Dupont, Feiyi Zhang, Shuyuan Li, Yang Wang, Zhenyu Liu, Yongfang Zheng, Shuli Liu, Yanlian Yang, Chen Wang, Lanlan Yu*, Yuxing Yao, Xiaoguang Wang*, Chenxuan Wang*, Single-molecule visualization determines conformational sub-state ensembles in β-sheet-rich peptide fibrils, Science Advances, 2023, 9(27), eadg794, DOI: 10.1126/sciadv.adg7943.

62. Lanlan Yu#, Ruonan Wang#, Shucong Li, Ufuoma I. Kara, Eric C. Boerner, Boyuan Chen, Feiyi Zhang, Zhongyi Jian, Shuyuan Li, Mingwei Liu, Yang Wang, Shuli Liu, Yanlian Yang, Chen Wang, Wenbo Zhang*, Yuxing Yao, Xiaoguang Wang*, Chenxuan Wang*, Experimental insights into conformational ensembles of assembled β-sheet peptides, ACS Central Science, 2023, 9(7), 1480–1487, DOI: 10.1021/acscentsci.3c00230.

61. Wenbo Zhang#, Mingwei Liu#, Yang Wang#, Xin Wang, Ruonan Wang, Shuyuan Li, Lanlan Yu, Feiyi Zhang, Chenxuan Wang*, b-Sheet assembly translates conservative single-site mutation into a perturbation in macroscopic structure, Nano Letters, 2023, 23(6), 2370-2378, DOI: 10.1021/acs.nanolett.3c00311.

60. Chenxuan Wang*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical organization of supramolecular systems: from fundamentals to biomedical applications, volume II, Frontiers in Bioengineering and Biotechnology, 2023, 11, 1177799, DOI: 10.3389/fbioe.2023.1177799.

2022 Publications

59. Meichen Zhang#, Yangyang Ge#, Shilin Xu, Xiaocui Fang, Jie Meng, Lanlan Yu, Chenxuan Wang, Jian Liu, Tao Wen, Yanlian Yang, Chen Wang*, Haiyan Xu*, Nanomicelles co-loading CXCR4 antagonist and doxorubicin combat the refractory acute myeloid leukemia, Pharmacological Research, 2022, 185, 106503, DOI: 10.1016/j.phrs.2022.106503.

58. Lanlan Yu#, Ruonan Wang#, Tao Wen#, Lei Liu, Tao Wang, Shuli Liu, Haiyan Xu*, Chenxuan Wang*, Peptide binder with high-affinity for the SARS-CoV-2 spike receptor-binding domain, ACS Applied Materials & Interfaces, 2022, 14(25), 28527–28536, DOI: 10.1021/acsami.2c03707.

57. Yan Zhao#, Shanshan Mo#, Lanlan Yu#, Xiaolu Li, Yun Hao, Wenbo Zhang, Qi Zhang, Ping Wang, Xiangdong Wang*, Chenxuan Wang*, Luo Zhang*, Crystalline state determines the potency of galectin-10 protein assembly to induce inflammation, Nano Letters, 2022, 22(6), 2350-2357, DOI: 10.1021/acs.nanolett.1c04817.

56. Feiyi Zhang#, Lanlan Yu#, Zhun Deng, Shuli Liu, Chenxuan Wang*, Lei Liu*, Composition-dependent wettability of nature-inspired homo poly(amino acid) coating and its influences on bacterial adhesion, European Polymer Journal, 2022, 168, 111127, DOI: 10.1016/j.eurpolymj.2022.111127.

55. Wenbo Zhang#, Mingwei Liu#, Lanlan Yu#, Shanshan Mo, Zhun Deng, Shuli Liu, Yanlian Yang, Chen Wang, Chenxuan Wang*, Perturbation effect of single polar group substitution on the self-association of amphiphilic peptide helices, Journal of Colloid and Interface Science, 2022, 610, 1005-1014, DOI: 10.1016/j.jcis.2021.11.154.

54. Zhichao Lou#, Qiuyi Wang, Xiaodi Zhou, Ufuoma I. Kara, Rajdeep S. Mamtani, Hualiang Lv*, Meng Zhang, Zhihong Yang, Yanjun Li, Chenxuan Wang*, Solomon Adera*, Xiaoguang Wang*, An angle-insensitive electromagnetic absorber enabling a wideband absorption, Journal of Materials Science & Technology, 2022, 113, 33-39, DOI: 10.1016/j.jmst.2021.11.007.

2021 Publications

53. Wenbo Zhang#, Mingwei Liu#, Robert L. Dupont, Kai Huang, Lanlan Yu, Shuli Liu, Xiaoguang Wang*, Chenxuan Wang*, Conservation and identity selection of cationic residues flanking the hydrophobic regions in intermediate filament superfamily, Frontiers in Chemistry, 2021, 9, 752630, doi: 10.3389/fchem.2021.752630.

52. Feiyi Zhang#, Lanlan Yu#, Wenbo Zhang#, Lei Liu*, Chenxuan Wang*, A minireview on the perturbation effects of polar groups to direct nanoscale hydrophobic interaction and amphiphilic peptide assembly, RSC Advances, 2021, 11, 28667-28673, doi: 10.1039/d1ra05463e.

51. Chenxuan Wang#*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical organization of supramolecular systems: from fundamentals to biomedical applications, Frontiers in Bioengineering and Biotechnology, 2021, 9, 754980, doi: 10.3389/fbioe.2021.754980.

50. Lanlan Yu#, Zhun Deng#, Wenbo Zhang, Shuli Liu, Feiyi Zhang, Jianjian Zhou, Chunhua Ma, Chenxuan Wang*, Opposite Regulatory Effects of immobilized cations on the folding versus assembly of melittin, Frontiers in Chemistry, 2021, 9, 685947, doi: 10.3389/fchem.2021.685947.

49. Yan Zhao#, Xiaolu Li#, Wenbo Zhang#, Lanlan Yu#, Yang Wang, Zhun Deng, Mingwei Liu, Shanshan Mo, Ruonan Wang, Jinming Zhao, Shuli Liu, Yun Hao, Xiangdong Wang, Tianjiao Ji*, Luo Zhang*, Chenxuan Wang*, Trends in the biological functions and medical applications of extracellular vesicles and analogues, Acta Pharmaceutica Sinica B, 2021, 11(8), 2114-2135, doi: 10.1016/j.apsb.2021.03.012.

48. Lanlan Yu#, Yongfang Zheng, Xiaocui Fang, Yimin Zou, Chenxuan Wang*, Yanlian Yang*, Chen Wang*, Composition-dependent multivalency of peptide-peptide interactions revealed by tryptophan-scanning mutagenesis, Journal of Peptide Science, 2021, 27, e3310, doi: 10.1002/psc.3310.

47. Shan He#, Xinyue He, Lei Liu, Wenbo Zhang, Lanlan Yu, Zhun Deng, Zhang Feiyi, Shanshan Mo, Yue Fan, Xinyue Zhao, Lun Wang, Chenxuan Wang*, Shuyang Zhang*, The structural understanding of transthyretin misfolding and the inspired drug approaches for the treatment of heart failure associated with transthyretin amyloidosis, Frontiers in Pharmacology, 2021, 12, 628184, doi: 10.3389/fphar.2021.628184.

46. Chenxuan Wang#, Naomi A. Biok, Karthik Nayani, Xiaoguang Wang, Hongseung Yeon, Chi-Kuen Derek Ma, Samuel H. Gellman*, Nicholas L. Abbott*, Cationic side chain identity directs the hydrophobically driven self-assembly of amphiphilic β-peptides in aqueous solution, Langmuir, 2021, 37, 3288-3298, doi: 10.1021/acs.langmuir.0c03255.

2020 Publications

45. Lanlan Yu#, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang*, Yanlian Yang, Chen Wang, Chenxuan Wang*, Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, Science Advances, 2020, 6(32), eabc1449, doi: 10.1126/sciadv.abc1449.

44. Wenbo Zhang#, Shanshan Mo#, Mingwei Liu#, Lei Liu, Lanlan Yu*, Chenxuan Wang*, Rationally designed protein building blocks for programmable hierarchical architectures, Frontiers in Chemistry, 2020, 8, 587975, doi: 10.3389/fchem.2020.587975.

43. Lanlan Yu#, Zhun Deng#, Lei Liu, Wenbo Zhang*, Chenxuan Wang*, Plant-derived nanovesicles: a novel form of nanomedicine, Frontiers in Bioengineering and Biotechnology, 2020, 8, 584391, doi: 10.3389/fbioe.2020.584391.

42. Wenbo Zhang#, Lanlan Yu, Tianjiao Ji*, Chenxuan Wang*, Tumor microenvironment-responsive peptide based supramolecular drug delivery system, Frontiers in Chemistry, 2020, 8, 549, doi: 10.3389/fchem.2020.00549.

41. Hongseung Yeon#, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Influence of immobilized cations on the thermodynamic signature of hydrophobic interactions at chemically heterogeneous surfaces, Molecular Systems Design and Engineering, 2020, 5(4), 835-846, doi: 10.1039/d0me00016g.

40. Qize Xuan#, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang*, Yibing Wang*, Ping Wang, Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity, Chemical Communications, 2020, 56(11), 1633-1636, doi: 10.1039/c9cc08671d.

2019 Publications

39. Naomi A. Biok#, Alexander D. Passow, Chenxuan Wang, Craig A. Bingman, Nicholas L. Abbott*, Samuel H. Gellman*, Retention of coiled-coil dimer formation in the absence of ion pairing at positions flanking the hydrophobic core, Biochemistry, 2019, 58(48), 4821-4826, doi: 10.1021/acs.biochem.9b00668.

38. Chenxuan Wang#, Travis Nelson, Dayue Chen, Joseph Christopher Ellis, Nicholas L. Abbott*, Understanding Lipopolysaccharide Aggregation and its Influence on Activation of Factor C, Journal of Colloid and Interface Science, 2019, 552, 540-553, doi: 10.1016/j.jcis.2019.05.013.

37. Xiaoyun Li#, Zhu Liang#, Jianchao Du#, Zhiqing Wang, Song Mei, Zhiqing Li, Yan Zhao, Dandan Zhao, Yiming Ma, Jun Ye, Jiantao Xu, Yu Zhao, Jiahui Chang, Yuhao Qin, Lanlan Yu, Chenxuan Wang*, Chengyu Jiang*, Herbal decoctosome is a novel form of medicine, Science China-Life Sciences, 2019, 62(3), 333-348, doi: 10.1007/s11427-018-9508-0.

36. Zhihui Yao#, Brian P. Cary, Craig A. Bingman, Chenxuan Wang, Dale F. Kreitler, Kenneth A. Satyshur, Katrina T. Forest, Samuel H. Gellman*, Use of a stereochemical strategy to probe the mechanism of phenol-soluble modulin alpha 3 toxicity, Journal of the American Chemical Society, 2019, 141(19), 7660-7664, doi: 10.1021/jacs.9b00349.

35. Qunxing Huang#, Qiong Zhao, Jiaxi Peng, Ooolalla Yu, Chenxuan Wang, Yimin Zou, Yanlei Su, Ling Zhu*, Chen Wang*, Yanlian Yang*, Peptide-polyphenol (KLVFF/EGCG) binary modulators for inhibiting aggregation and neurotoxicity of amyloid-beta peptide, ACS Omega, 2019, 4(2), 4233-4242, doi: 10.1021/acsomega.8b02797.

2018 Publications

34. Reza Abbasi#, Chenxuan Wang, Yiqun Bai, Nicholas L. Abbott*, Phosphorylation status of peptide monolayers modulates hydrogen bonding and orientations of nematic liquid crystals, Liquid Crystal, 2018, 45 (13-15), 2253-2268, doi: 10.1080/02678292.2018.1509389.

2017 Publications

33. Chenxuan Wang#, C. Derek Ma, Hongseung Yeon, Xiaoguang Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Nonadditive interactions mediated by water at chemically heterogeneous surfaces: nonionic polar groups and hydrophobic interactions, Journal of the American Chemical Society, 2017, 139(51), 18536-18544, doi: 10.1021/jacs.7b08367.

32. Hongseung Yeon#, Chenxuan Wang, Reid C. Van Lehn, Nicholas L. Abbott*, Influence of order within nonpolar monolayers on hydrophobic interactions, Langmuir, 2017, 33(19), 4628-4637, doi: 10.1021/acs.langmuir.7b00226.

31. Timothy J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Redox-triggered mixing and demixing of surfactants within assemblies formed in solution and at surfaces, Journal of Colloid and Interface Science, 2017, 502, 122-133, doi: 10.1016/j.jcis.2017.04.052.

30. Aihua Yang#, Chenxuan Wang, Baomin Song, Wendi Zhang, Yuanyuan Guo, Rong Yang, Guangjun Nie, Yanlian Yang*, Chen Wang*, Attenuation of beta-amyloid toxicity in vitro and in vivo by accelerated aggregation, Neuroscience Bulletin, 2017, 33(4), 405-412, doi: 10.1007/s12264-017-0144-z.

2016 Publications

29. C. Derek Ma#, Claribel Acevedo-Vélez, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Interaction of the hydrophobic tip of an atomic force microscope with oligopeptides immobilized using short and long tethers, Langmuir, 2016, 32(12), 2985-2995, doi: 10.1021/acs.langmuir.5b04618.

28. Juan Liu#, Tuo Wei, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowei Ma, Xingjie Liang*, Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance, Biomaterials, 2016, 91, 44-56, doi: 10.1016/j.biomaterials.2016.03.013.

2015 Publications

27. C. Derek Ma#, Chenxuan Wang, Claribel Acevedo-Vélez, Samuel H. Gellman*, Nicholas L. Abbott*, Modulation of hydrophobic interactions by proximally immobilized ions, Nature, 2015, 517(7534), 347-U443 doi: 10.1038/nature14018.

26. Yanmei Wang#, Chenxuan Wang#, Zhiqiang Cheng, Dongdong Zhang, Shaopeng Li, Lusheng Song, Wenfei Zhou, Mo Yang, Zhiyou Wang, Zheng Zheng, Baohang Han, Chen Wang*, Yanlian Yang*, Jinsong Zhu*, SPRi determination of inter-peptide interaction by using 3D supramolecular co-assembly polyrotaxane film, Biosensors and Bioelectronics, 2015, 66, 38-44, doi: 10.1016/j.bios.2014.11.025.

25. Timothy J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Influence of self-assembling redox mediators on charge transfer at hydrophobic electrodes, Langmuir, 2015, 31(39), 10638-10648, doi: 10.1021/acs.langmuir.5b02212.

24. Yang Sun#, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo, Dangsheng Li, Bo Li, Qihan Li, Nanshan Zhong, Chen Wang, Josef M. Penninger, Chengyu Jiang*, Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice, Particle and Fibre Toxicology, 2015, 12, 4, doi: 10.1186/s12989-015-0080-x.

2014 Publications

23. Yiqun Bai#, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott*, Liquid crystals anchored on mixed monolayers of chiral versus achiral molecules: continuous change in orientation as a function of enantiomeric excess, Angewandte Chemie International Edition, 2014, 53 (31), 8079-8083, doi: 10.1002/anie.201402770.

22. Huiwen Du#, Denghua Li, Yibin Wang, Chenxuan Wang, Ping Li, Yanlian Yang*, Chen Wang*, Peptide-assisted directional adsorption of purple membrane at the liquid-solid interface, Journal of Physical Chemistry C, 2014, 118 (51), 29770-29776, doi: 10.1021/jp5077017.

2013 Publications

21. Min Zhang#, Xiaobo Mao, Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang*, Wei Liang*, Chen Wang*, The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr), Biomaterials, 2013, 34 (4), 1383-1390, doi: 10.1016/j.biomaterials.2012.10.067.

20. Min Zhang#, Xiaobo Mao, Yue Yu, Chenxuan Wang, Yanlian Yang*, Chen Wang*, Nanomaterials for reducing amyloid cytotoxicity, Advanced Materials, 2013, 25(28), 3780-3801, doi: 10.1002/adma.201301210.

19. Huiwen Du#, Denghua Li, Yibing Wang, Chenxuan Wang, Dongdong Zhang, Yanlian Yang*, Chen Wang*, Determination of the surface charge density and temperature dependence of purple membrane by electric force microscopy, Journal of Physical Chemistry B, 2013, 117(34), 9895-9899, doi: 10.1021/jp403075w.

18. Ting Zhou#, Axel Llizo, Ping Li, Chenxuan Wang, Yuanyuan Guo, Mingqi Ao, Linling Bai, Chen Wang*, Yanlian Yang*, Guiying Xu*, High transfection efficiency of homogeneous DNA nanoparticles induced by imidazolium gemini surfactant as nonviral vector, Journal of Physical Chemistry C, 2013, 117(50), 26573-26581, doi: 10.1021/jp4061363.

2012 Publications

17. Chenxuan Wang#, Aihua Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang*, Chen Wang*, Observation of molecular inhibition and binding structures of amyloid peptides, Nanoscale, 2012, 4(6), 1895-1909, doi: 10.1039/c2nr11508e.

16. Yuanyuan Guo#, Chenxuan Wang, Jingfei Hou, Aihua Yang, Xuemei Zhang, Yibing Wang, Min Zhang, Yanlian Yang*, Chen Wang*, Odd-even sequence effect of surface-mediated peptide assemblies observed by scanning tunneling microscopy, Chinese Journal of Chemistry, 2012, 30 (9), 1987-1991, doi: 10.1002/cjoc.201200656.

15. Jie Song#, Menglin Chen, Viduthalai Regina, Chenxuan Wang, Rikke Meyer, Erqing Xie, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Safe and effective Ag nanoparticles immobilized antimicrobial nanononwovens, Advanced Engineering Materials, 2012, 14(5), B240-B246, doi: 10.1002/adem.201180085.

14. Peng Liu#, Shuai Zhang, Meisha Chen, Qian Liu, Chenxuan Wang, Chen Wang, Yanmei Li*, Flemming Besenbacher, Mingdong Dong*, Co-assembly of human islet amyloid polypeptide (hIAPP)/insulin, Chemical Communications, 2012, 48(2), 191-193, doi: 10.1039/c1cc14285b.

2011 Publications

13. Xiaobo Mao#, Chenxuan Wang#, Xingkui Wu, Lei Liu, Lan Zhang, Lin Niu, Yanlian Yang*, Chen Wang*, Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies, Proceedings of the National Academy of Sciences of the USA, 2011, 108(49), 19605-19610, doi: 10.1073/pnas.1102971108.

12. Chenxuan Wang#, Xiaobo Mao#, Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibin Wang, Yanlian Yang*, Chen Wang*, Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy, Chemical Communications, 2011, 47(38), 10638-10640, doi: 10.1039/c1cc12380g.

11. Xiaobo Mao#, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Molecular level studies on binding modes of labeling molecules with polyalanine peptides, Nanoscale, 2011, 3(4), 1592-1599, doi: 10.1039/c0nr00782j.

10. Xiaobo Mao#, Yuanyuan Guo, Chenxuan Wang, Min Zhang, Xiaojing Ma, Lei Liu, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy, ACS Chemical Neuroscience, 2011, 2(6), 281-287, doi: 10.1021/cn200006h.

9. Zengguang Cheng#, Qiaoyu Zhou, Chenxuan Wang, Qiang Li, Chen Wang, Ying Fang*, Toward intrinsic graphene surfaces: a systematic study on thermal annealing and wet-chemical treatment of SiO₂-supported graphene devices, Nano Letter, 2011, 11(2), 767-771, doi: 10.1021/nl103977d.

8. Jie Song#, Menglin Chen, Mikkel Buster Olesen, Chenxuan Wang, Rasmus Havelund, Qiang Li, Erqing Xie, Rong Yang, Peter Boggild, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Direct electrospinning of Ag/polyvinylpyrrolidone nanocables, Nanoscale, 2011, 3(12), 4966-4971, doi: 10.1039/c1nr10512d.

7. Weiwei He#, Shuai Hou, Xiaobo Mao, Xiaochun Wu*, Yinglu Jin, Jianbo Liu, Xiaona Hu, Ke Zhang, Chenxuan Wang, Yanlian Yang, Qi Wang, Peptide-tailored assembling of Au nanorods, Chemical Communications, 2011, 47(19), 5482-5484, doi: 10.1039/c1cc10394f.

2010 Publications

6. Xiaobo Mao#, Chenxuan Wang, Lei Liu, Xiaojing Ma, Lin Niu, Yanlian Yang*, Chen Wang*, Study on the fine structure of polypeptides at solid-liquid interfaces by scanning tunneling microscopy, Acta Physico-Chimica Sinica, 2010, 26(4), 850-861, doi: 10.3866/PKU.WHXB20100440.

5. Xuemei Zhou#, Hongchao Yang, Chenxuan Wang, Yinfang Cui, Xiaobo Mao, Cong Wang, Yinshu Wang, Gang Liu*, Visible light induced photocatalytic degradation rhodamine B on one-dimensional iron oxide particles, Journal of Physical Chemistry C, 2010, 114(40), 17051-17061, doi: 10.1021/jp103816e.

4. Xiaobo Mao#, Hongchao Yang, Xuemei Zhou, Chenxuan Wang, Yinshu Wang, Yanlian Yang, Chen Wang, Gang Liu*, Straight and Branched Goethite Topology by Oriented Attachment at High pH, Crystal Growth & Design, 2010, 10(2), 504-509, doi: 10.1021/cg900392m.

3. Tao Zhang#, Zengguang Cheng, Yibing Wang, Zhongjun Li, Chenxuan Wang, Yibao Li, Ying Fang*, Self-assembled 1-octadecanethiol monolayers on graphene for mercury detection, Nano Letters, 2010, 10(11), 4738-4741, doi: 10.1021/nl1032556.

2. Hongchao Yang#, Xuemei Zhou, Tengteng Tang, Xiaoying Qi, Chenxuan Wang, Jinyao Lan, Yinshu Wang, Yanlian Yang, Gang Liu*, Anisotropic growth of multi-twinned goethite particles by oriented aggregation, CrystEngComm, 2010, 12(12), 4007-4009, doi: 10.1039/c0ce00437e.

1. Jie Jiang#, Xiaoliang Tang, Wei Dou, Huihui Zhang, Weisheng Liu*, Chenxuan Wang, Jiangrong Zheng, Synthesis and characterization of the ligand based on benzoxazole and its transition metal complexes: DNA-binding and antitumor activity, Journal of Inorganic Biochemistry, 2010, 104(5), 583-591, doi: 10.1016/j.jinorgbio.2010.01.011.

著作

Books and Chapters

3. Lanlan Yu#, Yanlian Yang, Chen Wang, Chenxuan Wang*. Peptide Assemblies on Surfaces: A Study Using Scanning Tunneling Microscopy. In: Xuehai Yan (eds) Peptide Self-Assembly and Engineering, 2 Volumes: Fundamentals, Structures, and Applications. 2024, Wiley-VCH, Weinheim, Germany.

2. Wenbo Zhang#, Lanlan Yu, Chenxuan Wang*. Intermolecular interactions and self-assembly of peptide-based nanomaterials against human pathogenic bacteria. In: Haiyan Xu, Ning Gu. (eds) Nanotechnology in regenerative medicine and drug delivery therapy. 2020, Springer, Singapore

1. 王晨轩#，杨延莲*，王琛*. 《纳米生物医学光电子学前沿》第七章《淀粉样蛋白的结构分析研究进展》科学出版社，2013年，北京

发明专利

Patents

18. 王晨轩，张文博，李淑媛，王洋. 离子型多肽及其在缓解Gal-10结晶相关疾病中的应用。国家发明专利. 授权公告日2026-04-10, 专利号 ZL202410074492.2

17. 王晨轩，邓准，于兰兰，简中意，张文博. 稀释诱导相分离多肽及其应用。国家发明专利. 授权公告日2025-11-21, 专利号 ZL202510493525.1

16. 王晨轩，张文博，王洋，李淑媛. 二甲双胍及其它含胍化合物在逆转Gal-10结晶趋势并缓解相关疾病中应用。国家发明专利. 授权公告日2024-03-19, 专利号 ZL202210534642.4

15. 王晨轩，张罗，莫珊珊，王向东，于兰兰，赵妍，李小璐，张文博，郝蕴. 多肽在制备治疗2型免疫疾病的药物中的应用。国家发明专利. 授权公告日2022-08-19, 专利号 ZL202111008545.3

14. 王晨轩，莫珊珊，于兰兰，张罗，赵妍，王向东，李小璐，张文博，郝蕴. 用于治疗2型免疫疾病的多肽。国家发明专利. 授权公告日2022-08-19, 专利号 ZL202111008519.0

13. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种亲和肽在制备抗冠状病毒药物中的应用。国家发明专利. 授权公告日2022-07-15, 专利号 ZL202110178816.3

12. 王晨轩，莫珊珊，张罗，赵妍，于兰兰，王向东，李小璐，张文博，郝蕴. 靶向夏科-莱登结晶蛋白的多肽及其应用。国家发明专利. 授权公告日2022-05-03, 专利号 ZL202111008517.1

11. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种亲和肽M5稳定的纳米金颗粒及其制备方法和用途。国家发明专利. 授权公告日2022-04-01, 专利号 ZL202110529881.6

10. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种新型冠状病毒主蛋白酶的亲和肽M1及其应用。国家发明专利. 授权公告日2022-02-08, 专利号 ZL202110231722.8

9. 王晨轩，于兰兰，王琛，杨延莲. 一种研究蛋白质及药物-蛋白质复合体构象多态性的方法。国家发明专利. 授权公告日2021-03-05,专利号 ZL202010070997.3

8. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种低溶血活性的蜂毒肽及其应用。国家发明专利. 授权公告日2020-04-28,专利号 ZL201910854177.0

7. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种蜂毒肽变体及其应用。国家发明专利. 授权公告日2020-05-12,专利号 ZL201910854956.0

6. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp41蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-03-01,专利号 ZL201310298420.8

5. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp120蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-06-27,专利号 ZL201310298450.9

4. 张敏，李平，王晨轩，杨延莲，王琛. 抑制b淀粉样蛋白聚集和毒性的多肽抑制剂及其应用。国家发明专利. 授权公告日2017-12-12,专利号 ZL201310294070.8

3. 王琛，杨爱华，王晨轩，杨延莲. 调节b淀粉样蛋白生理毒性的多肽。国家发明专利. 授权公告日2017-12-26,专利号 ZL201310421560.X

2. 王琛，张敏，王晨轩，杨延莲. 一种抑制人胰淀素聚集或毒性的多肽、试剂及其应用。国家发明专利. 授权公告日2015-11-25,专利号 ZL201210410206.2

1. 王琛，杨延莲，许海燕，李潇瑾，张卫奇，孟洁，王晨轩. 一种增强肿瘤细胞对抗肿瘤药物敏感性的多肽及其应用。国家发明专利.授权公告日2018-5-4,专利号 ZL201310298419.5

课题组导师团队

于兰兰，副研究员，硕士生导师	张文博，副研究员，硕士生导师
教育及工作经历 2009-2013年，南京理工大学高分子材料与工程专业，本科。 2013-2018年，中国科学院国家纳米科学中心与清华大学化学系联合培养研究生，物理化学专业。导师王琛研究员、杨延莲研究员、李艳梅教授。研究方向：在单分子水平研究蛋白折叠与组装结构及多肽-多肽/糖相互作用。2017年7月，以色列巴伊兰大学访学。2018年获清华大学理学博士学位。 2018至今，中国医学科学院基础医学研究所/北京协和医学院基础学院，历任博士后、助理研究员、副研究员、硕士生导师。	教育及工作经历 2009-2013年，中国农业大学生物学院，生物科学专业，本科。 2013-2019年，北京大学，北京核磁共振中心，生物化学与分子生物学专业。导师金长文教授，理学博士。研究方向：核磁共振技术研究蛋白质的结构、动态特性与功能关系。 2019至今，中国医学科学院基础医学研究所/北京协和医学院基础学院生物物理与结构生物学系，王晨轩研究员课题组。历任助理研究员、副研究员、硕士生导师。
研究方向 围绕蛋白质的折叠与组装这一科学问题，重点研究与疾病相关蛋白质的组装与调控，在单分子水平解析组装结构中的构象多态性与动态演变规律，进一步研究其调控规律；基于脑库样本，研究病理性蛋白的组装构象与相关疾病表型之间的关联规律；基于对蛋白质组装过程中分子间相互作用的理解，研究蛋白质发生液-液相转变以及固化成熟的过程，解析与疾病之间的关联性，进一步实现对这一过程的有效调控；关注蛋白质寡聚化与药物分子的选择性寡聚化，研究寡聚化与生物功能的关联性；靶向药物分子的设计与筛选研究。承担八年制课、研究生课《生物物理学》教学任务。先后主持北京市科技新星计划、国家自然科学基金青年项目、协和新星项目、中国博士后科学基金新冠肺炎疫情防控专项。	研究方向 蛋白质的正确折叠与错误折叠与人体生理病理过程密切相关。针对多种疾病相关蛋白，包括：炎症相关蛋白、皮肤病相关蛋白、眼部疾病相关蛋白、脑疾病相关蛋白等，主要利用多种生物物理技术包括：液体核磁共振、多种显微术、光散射等，研究疾病相关蛋白质的折叠结构、组装结构及其与生理功能之间的关联规律，开发小分子、多肽类靶向药物，并阐述其与蛋白质相互作用的分子机制，包括相互作用方式及相互作用位点，深入理解靶向性药物调控疾病相关蛋白质/多肽折叠组装结构的规律，为干预相关病症的发生与发展提供科学依据与潜在的新方法。承担八年制课、研究生课《生物物理学》教学任务。先后主持国家自然科学基金青年项目、协和新星项目、中央高校基本科研业务费项目、企业横向项目等项目。
联系方式 Email: yull@ibms.pumc.edu.cn	联系方式 Email: zwb@ibms.pumc.edu.cn