科研方向： [1] 多肽及其偶联物研发，发展抗肿瘤治疗新方法，针对白血病、胰腺癌、乳腺癌等。 [2] 药物递送系统，主要包括阳离子多糖、贵金属合金、胶束和脂质体等，用于核酸药物、多肽药物、小分子化药的靶向递送。 [3] 具有电、磁、力响应性的纳米结构复合材料的设计与制备，用于调控细胞行为、提高医疗器械表面生物相容性、以及引导组织再生与大块缺损组织的修复，主要包括骨、肌肉、心肌等。 [4] 纳米材料毒理学效应与临床安全应用，重点探索和研究具有医学应用转化潜力的纳米材料的生物学效应，如对免疫系统、血管内皮的作用及分子机制。 教学工作： [1] 担任北京协和医学院研究生《纳米医学概论》课程负责人。个人授课内容：绪论、纳米技术在再生医学和免疫治疗中的研究与应用。 [2] 北京协和医学院研究生课程《生物医学工程概论》、《生理学的物理分析》、《心血管生理学：基础与临床》中部分授课任务，授课内容主要包括：生物材料与人工器官和再生医学、生物材料物理学与组织再生、生物材料及医疗器械在心血管系统中的应用研究。 [3] 北京协和医学院临床医学本科课程《生物医学工程》部分授课任务，授课内容：生物材料、人工器官、组织工程与再生医学。
第一部分：纳米医学与抗肿瘤治疗
Part 1: Nanomedicine & Anti-tumor therapies
1. Yiling Meng, Tao Wen*, Xuanxin Liu, Aiyun Yang, Jie Meng, Jian Liu, Jianhua Wang, Haiyan Xu,* Simultaneous targeting and suppression of heat shock protein 60 to overcome heat resistance and induce mitochondrial death of tumor cells in photothermal immunotherapy. Materials Today Bio. 2024; 29: 101282.
2. Wang T, Zhang W, Chen W, Meng J, Hu Q, Liu J, Wen T, Han B*, Xu H*. As4S4 nanoparticles promote effective terminal erythropoiesis in bone marrow mononuclear cells from patients with myelodysplastic syndromes. Nano Today. 2023; 52: 101965
3. Meng Y#, Zhou J#, Liu X, Zeng F, Wen T*, Meng J, Liu J, Xu H*. CXC Chemokine Receptor Type 4 Antagonistic Gold Nanorods Induce Specific Immune Responses and Long-Term Immune Memory to Combat Triple-Negative Breast Cancer. ACS Applied Materials & Interfaces. 2023; 15(15):18734–18746.
4. Zhang S, Wang T, Xue J, Xu H*, Wu S*. Hydrogen Bonding Principle-Based Molecular Design of a Polymer Excipient and Impacts on Hydrophobic Drug Properties: Molecular Simulation and Experiment. Biomacromolecules. 2023; 24(4): 1675-1688.
5. Huimin Wang, Hong Deng, Menghan Gao, Yiyi Zhang, Runmeng Liu, Wei Hou, Haiyan Xu*, Weiqi Zhang*. Radiotherapy Potentiates the P‑Selectin Targeted Cancer Drug Delivery Based on a Cisplatin and Mitoxantrone Coassembled Fucoidan Nanogel. ACS Materials Letters 2023; 5(10): 2843-2851.
6. Hong Deng, Xue Yang, Huimin Wang, Menghan Gao, Yiyi Zhang, Runmeng Liu, Haiyan Xu*, Weiqi Zhang*. Tailoring the surface charges of iron-crosslinked dextran nanogels towards improved tumor-associated macrophage targeting. Carbohydrate Polymers 2023; 325(17): 121585.
7. Zhang M#, Ge Y#, Xu S, Fang X, Meng J, Yu L, Wang C, Liu J, Wen T, Yang Y, Wang C, Xu H. Nanomicelles co-loading CXCR4 antagonist and doxorubicin combat the refractory acute myeloid leukemia. Pharmacol Res. 2022 Nov; 185:106503.
8. Xu S, Zhang M, Fang X, Hu X, Xing H, Yang Y, Meng J, Wen T, Liu J, Wang J, Wang C*, Xu H*. CD123 Antagonistic Peptides Assembled with Nanomicelles Act as Monotherapeutics to Combat Refractory Acute Myeloid Leukemia. ACS Appl Mater Interfaces. 2022 Aug 31; 14(34): 38584-38593.
9. Tian Wang, Boya Hao, Shilin Xu, Jie Meng, Tao Wen, Jian Liu*, Haiyan Xu*. Effective RNAi in leukemia cells is enhanced by spermine-modified pullulancombined with desloratadine. Carbohydrate Polymers. 2022; 292: 119646.
10. Wang T, Zhang X, Jia M, Yang A, Liu J, Wen T, Meng J*, Xu H*. Hydrophilic Realgar Nanocrystals Prolong the Survival of Refractory Acute Myeloid Leukemia Mice Through Inducing Multi-Lineage Differentiation and Apoptosis. Int J Nanomedicine. 2022 May 16; 17: 2191-2202.
11. Yu L#, Wang R#, Wen T#, Liu L, Wang T, Liu S, Xu H*, Wang C*. Peptide Binder with High-Affinity for the SARS-CoV-2 Spike Receptor-Binding Domain. ACS Appl Mater Interfaces. 2022 Jun 29; 14(25): 28527-28536.
12. Ruan L, Lu L, Zhao X, Xiong W, Xu H, Wu S. Effects of natural antioxidants on the oxidative stability of Eucommia ulmoides seed oil: Experimental and molecular simulation investigations. Food Chem. 2022 Jul 30; 383:132640.
13. Xu S, Zhang M, Fang X, Meng J, Xing H, Yan D, Liu J, Yang Y, Wen T, Zhang W, Wang J*, Wang C*, Xu H*. A novel CD123-targeted therapeutic peptide loaded by micellar delivery system combats refractory acute myeloid leukemia. J Hematol Oncol. 2021 Nov 13; 14(1): 193.
14. Tao Wang, Xiaocui Fang, Tao Wen, Jian Liu, Zhaoyi Zhai , Zhiyou Wang, Jie Meng, Yanlian Yang, Chen Wang*, Haiyan Xu*. Synthetic Neutralizing Peptides Inhibit the Host Cell Binding of Spike Protein and Block Infection of SARS-CoV-2. J Med Chem. 2021 Oct 14; 64(19): 14887-14894.
15. Bo Han#, Tao Wang#, Zhigang Xue, Tao Wen, Ling Lu, Jie Meng, Jian Liu, Sizhu Wu, Jianchun Yu*, Haiyan Xu*. Elemene Nanoemulsion Inhibits Metastasis of Breast Cancer by ROS Scavenging. International Journal of Nanomedicine 2021; 16, 6035-6048
16. Fei Kong, Huiyuan Bai, Ming Ma, Chen Wang, Haiyan Xu*, Ning Gu*, Yu Zhang*. Fe3O4@Pt nanozymes combining with CXCR4 antagonists to synergistically treat acute myeloid leukemia. NanoToday 2021; 37, 101106.
17. Bai H, Sun Q, Kong F, Dong H, Ma M, Liu F, Wang C, Xu H, Gu N, Zhang Y. Zwitterion-functionalized hollow mesoporous Prussian blue nanoparticles for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia. J Mater Chem B. 2021 Jul 7; 9(26): 5245-5254.
18. Huiyuan Bai, Tao Wang, Fei Kong, Meichen Zhang, Zhuoxuan Li, Linlin Zhuang, Ming Ma, Fangzhou Liu, Chen Wang, Haiyan Xu*, Ning Gu*, Yu Zhang*. CXCR4 and CD44 Dual-Targeted Prussian Blue Nanosystem with Daunorubicin Loaded for Acute Myeloid Leukemia Therapy, Chemical Engineering Journal, 2021, 405, 126891.
19. 王田, 许仕琳, 王涛, 温涛, 孟洁, 刘健, 许海燕. 精胺-普鲁兰联合地氯雷他定介导的NOTCH1沉默对急性Ｔ淋巴细胞白血病细胞系Jurkat的影响. 基础医学与临床2021, 41(6): 786-791
20. 孙博, 蒙艺灵, 温涛, 孟洁, 刘健, 许海燕. 多肽修饰的金纳米颗粒对小鼠三阴性乳腺癌细胞的靶向光热效应研究. 北京生物医学工程 2021, 40 (5), 441-446.
21. Meng J#, Ge Y#, Xing H#, Wei H, Xu S, Liu J, Yan D, Wen T, Wang M, Fang X, Ma L, Yang Y, Wang C*, Wang J*, Xu H*. Synthetic CXCR4 Antagonistic Peptide Assembling with Nanoscaled Micelles Combat Acute Myeloid Leukemia. Small, 2020; 12(45): 23084-23091.
22. Yan D#, Wei H#, Lai X, Ge Y, Xu S, Meng J, Wen T, Liu J, Zhang W*, Wang J*, Xu H*. Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy of refractory acute myeloid leukemia. Journal of Controlled Release. 2020, 327: 766-778.
23. Wen T#, Yang A#, Wang T, Jia M, Lai X, Meng J, Liu J, Han B, Xu H*. Ultra-small platinum nanoparticles on gold nanorods induced intracellular ROS fluctuation to drive megakaryocytic differentiation of leukemia cells. Biomater Sci, 2020; 8(22): 6204-6211.
24. Wang T#, Dong H#, Zhang M, Wen T, Meng J, Liu J, Li Z, Zhang Y*, Xu H*. Prussian blue nanoparticles induced myeloid leukemia cells differentiate towards red blood cells by nanozyme activities. Nanoscale 2020, 12, 23084.
25. Zhang W#, Han B#, Lai X, Xiao C, Xu S, Meng X, Li Z, Meng J, Wen T, Yang X, Liu J*, Xu H*. Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells. Chemical Communications. 2020; 56 (8): 1255-1258.
26. Ji S, Yang X, Chen X, Li A, Yan D, Xu H, Fei H*. Structure-tuned membrane active Ir-complexed oligoarginine overcomes cancer cell drug resistance and triggers immune responses in mice. Chemical Science. 2020; 11 (34): 9126-9133.
27. Zu R#, Fang X#, Lin Y, Xu S, Meng J, Xu H*, Yang Y*, Wang C*. Peptide-enabled receptor-binding-quantum dots for enhanced detection and migration inhibition of cancer cells. J Biomater Sci Polym Ed. 2020; 31(12): 1604-1621.
28. Kaiyue Zhang, Xiaocui Fang, Qing You, Yuchen Lin, Lilusi Ma, Shilin Xu, Yangyang Ge, Haiyan Xu*, Yanlian Yang*, and Chen Wang*. Novel Peptide-directed Liposomes for Targeted Combination Therapy of Breast Tumor. Mater. Adv., 2020, 1, 3483
29. Fang X, Zhang K, Jiang M, Ma L, Liu J, Xu H*, Yang Y*, Wang C*. Enhanced lymphatic delivery of nanomicelles encapsulating CXCR4-recognizing peptide and doxorubicin for the treatment of breast cancer. Int J Pharm., 2020 Dec 18; 594:120183.
30. Lu L, Luo K, Yang W, Zhang S, Wang W, Xu H*, Wu S*. Insight into the anti-aging mechanisms of natural phenolic antioxidants in natural rubber composites using a screening strategy based on molecular simulation. RSC Advances. 2020; 10, 21318.
31. Li H#, Wen T#, Wang T, Ji Y, Shen Y, Chen J, Xu H*, Wu X*. In Vivo Metabolic Response upon Exposure to Gold Nanorod Core/Silver Shell Nanostructures: Modulation of Inflammation and Upregulation of Dopamine. International Journal of Molecular Sciences. 2020 Jan 8; 21(2): 384.
32. Lanlan Yu, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang*, Yanlian Yang, Chen Wang, Chenxuan Wang*. Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T. Sci. Adv. 2020 Aug 5; 6(32): eabc1449.
33. Liu X, Liu J, Liu D, Han Y, Xu H, Liu L, Leng X, Kong D. A cell-penetrating peptide-assisted nanovaccine promotes antigen cross-presentation and anti-tumor immune response. Biomater Sci. 2019 Dec 1; 7(12): 5516-5527.
34. Zhang J , Liu D , Liu J , Han Y , Xu H , Leng X , Kong D , Liu L. Hybrid spherical nucleotide nanoparticles can enhance the synergistic anti-tumor effect of CTLA-4 and PD-1 blockades. Biomater Sci. 2020 Sep 7; 8(17): 4757-4766.
35. Wang T, Wen T, Li H, Han B, Hao S, Wang C, Ma Q, Meng J, Liu J, Xu H. Arsenic sulfide nanoformulation induces erythroid differentiation in chronic myeloid leukemia cells through degradation of BCR-ABL. Int J Nanomedicine. 2019 Jul 22; 14: 5581-5594.
36. Wang T, Meng J*, Wang C, Wen T, Jia M, Ge Y, Xie L, Hao S, Liu J, Xu H*. Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1α Downregulation. Front Oncol. 2019 Apr 26; 9: 333.
37. Mengfan Jia#, Tao Wang#, Shilin Xu, Jian Liu, Tao Wen, Jie Meng*, Haiyan Xu*. Arsenic Sulfide Nanoformulation Induces Megakaryocytic Differentiation through Histone Deacetylase Inhibition. Advanced Therapeutics. 2019 Nov 21; 3, 1900151.
38. Xie L, Yang Y, Meng J, Wen T, Liu J*, Xu H*. Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression. Int J Biol Macromol. 2018 Nov 13; 123:1012-1019.
39. Meng M, Xue H, Lei J, Wang Q, Liu J, Li Y, Sun T, Xu H, Jin Z*. A novel approach to monitoring the efficacy of anti-tumor treatments in animal models: combining functional MRI and texture analysis. BMC Cancer. 2018 Aug 20; 18(1): 833.
40. 杨扬, 孟洁. 温涛, 陈博, 刘飞, 顾宁, 许海燕, 于薇*, 刘健*. uPAR靶向性MRI探针的制备及其与乳腺癌细胞靶向结合的研究. 中国生物医学工程学报2018: 37(4): 481-488
41. Zhang W, Meng X, Liu H, Xie L, Liu J*, Xu H*. Ratio of Polycation and Serum Is a Crucial Index for Determining the RNAi Efficiency of Polyplexes. ACS Appl Mater Interfaces. 2017 Dec 20; 9(50): 43529-43537.
42. Hua Guo, Yangyang Ge, Xiaojin Li, Yanlian Yang, Jie Meng, Jian Liu, Chen Wang*, Haiyan Xu*. Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression. Signal Transduction and Targeted Therapy 2017; 2, 17033
43. Wang J, Xie L, Wang T, Wu F, Meng J, Liu J*, Xu H*. Visible light-switched cytosol release of siRNA by amphiphilic fullerene derivative to enhance RNAi efficacy in vitro and in vivo. Acta Biomater. 2017; 59: 158-169.
44. Fang X, Xie H, Duan H, Li P, Yousaf M, Xu H*, Yang Y*, Wang C*. Anti-tumor activity of nanomicelles encapsulating CXCR4 peptide antagonist E5. PLoS One. 2017 Aug 9; 12(8): e0182697.
45. Ma Q#, Wang C#, Li X, Guo H, Meng J, Liu J*, Xu H*. Fabrication of water-soluble polymer-encapsulated As4S4 to increase oral bioavailability and chemotherapeutic efficacy in AML mice. Sci Rep. 2016; 6:29348
46. Yang S, Meng J, Yang Y, Liu H, Wang C, Liu J, Zhang Y, Wang C*, Xu H*. A HSP60-targeting peptide for cell apoptosis imaging. Oncogenesis. 2016; 5:e201.
47. Meng J, Guo F, Xu H, Liang W, Wang C*, Yang XD*. Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in Liposomes for Drug Resistance Reversal in Breast Cancer Cells in vivo. Sci Rep. 2016; 6: 22390.
48. Duan H, Zhu L, Hou J, Peng J, Xie H, Lin Y, Liu C, Li W, Xu H*, Wang C*, Yang Y*. Dual-affinity peptide mediated inter-protein recognition. Org Biomol Chem. 2016 Dec 28; 14(48): 11342-11346.
49. Wen T, Wamer WG, Subczynski WK, Hou S, Wu X, Yin JJ*. Enhancement of Paramagnetic Relaxation by Photoexcited Gold Nanorods. Sci Rep. 2016; 6:24101
50. 刘会可#, 张卫奇#, 孟洁, 刘健*, 许海燕*. 血清蛋白与阳离子多糖的质量比对RNAi效率的调控作用研究. 中国科学:生命科学. 2016; 46:744-750.
51. 王晶, 谢丽菲, 孟洁, 刘健*, 许海燕*. 阴离子化高分子包覆非病毒载体提高有血清环境下RNA干扰效率的研究. 中国生物医学工程学报. 2016; 35(4): 445-452.
52. Li X#, Guo H#, Duan H, Yang Y, Meng J, Liu J, Wang C*, Xu H*. Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis. Sci Rep. 2015; 5:16228.
53. Meng J, Liu Y, Gao S, Lin S, Gu X, Pomper MG, Wang PC, Shan L*. A bivalent recombinant immunotoxin with high potency against tumors with EGFR and EGFRvIII expression. Cancer Biol Ther. 2015; 16(12): 1764-1774.
54. Meng J, Li X, Wang C, Guo H, Liu J, Xu H*. Carbon nanotubes activate macrophages into a M1/M2 mixed status: recruiting naïve macrophages and supporting angiogenesis. ACS Appl Mater Interfaces 2015; 7(5): 3180-3188.
55. Zhang W, Liu J*, Tabata Y, Meng J, Xu H*. The effect of serum in culture on RNAi efficacy through modulation of polyplexes size. Biomaterials 2014; 35(1): 567-577.
56. Li X, Guo H, Yang Y, Meng J, Liu J, Wang C*, Xu H*. A designed peptide targeting CXCR4 displays anti-acute myelocytic leukemia activity in vitro and in vivo. Sci Rep. 2014 Oct 14; 4: 6610.
57. Zhang W, Ji Y, Wu X*, Xu H*. Trafficking of Gold Nanorods in Breast Cancer Cells: Uptake, Lysosome Maturation, and Elimination. ACS Appl Mater Interfaces 2013; 5(19): 9856-9865.
58. Zhang L, Zhao S, Duan J, Hu Y, Gu N, Xu H, Yang XD*. Enhancement of DC-mediated anti-leukemic immunity in vitro by WT1 antigen and CpG co-encapsulated in PLGA microparticles. Protein & Cell. 2013; 4(12):887-9.
59. Yang M, Meng J, Cheng X, Lei J, Guo H, Zhang W, Kong H, Xu H*. Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis. Theranostics 2012; 2(3): 258-70.
60. Zhang W, Ji Y, Meng J, Wu X, Xu H*. Probing the behaviors of gold nanorods in metastatic breast cancer cells based on UV-vis-NIR absorption spectroscopy. PLoS One 2012; 7(2): e31957.
61. Zhang W#, Meng J#, Ji Y, Li X, Kong H, Wu X, Xu H*. Inhibiting metastasis of breast cancer cells in vitro using gold nanorod-siRNA delivery system. Nanoscale 2011; 3(9): 3923-2932
62. Yu C#, Hu Y#, Duan J, Yuan W, Wang C, Xu H, Yang XD*. Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro. PLoS One 2011; 6(9): e24077.
63. Sun Z#, Liu Z#, Meng J, Meng J, Duan J, Xie S, Lu X, Zhu Z, Wang C, Chen S, Xu H*, Yang XD*. Carbon nanotubes enhance cytotoxicity mediated by human lymphocytes in vitro. PLoS One 2011; 6(6): e21073.
64. Meng J#, Yang M#, Jia F, Kong H, Zhang W, Wang C, Xing J, Xie S, Xu H*. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity. Nanotechnology 2010; 21(14): 145104.
65. Sun Z#, Wang W#, Meng J, Chen S, Xu H*, Yang XD*. (Letter to Editor) Multi-walled carbon nanotubes conjugated to tumor protein enhance the uptake of tumor antigens by human dendritic cells in vitro. Cell Res. 2010 Oct; 20(10): 1170-3.
66. Sun Z#, Wang W#, Wang R, Duan J, Hu Y, Ma J, Zhou J, Xie S, Lu X, Zhu Z, Chen S, Zhao Y, Xu H, Wang C, Yang XD*. Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine. Cancer Nanotechnol. 2010; 1(1-6): 63-69.
67. Jia F#, Wu L#, Meng J, Yang M, Kong H, Liu T*, Xu H*. Preparation, characterization and fluorescent imaging of multi-walled carbon nanotube–porphyrin conjugate, Journal of Materials Chemistry 2009; 19(47): 8950-8957.
68. Meng J#, Meng J#, Duan J, Kong H, Wang C, Xie S, Chen S, Xu H*, Yang XD*. Carbon Nanotubes Conjugated to Tumor Lysate Protein Enhance the Efficacy of an Anti-tumor Immunotherapy. Small 2008; 4(9): 1364-1370.
69. 何朝辉, 邢建民, 孔桦, 许海燕*. 载硫酸庆大霉素聚乳酸纳米粒制备的正交设计及体外释药行为研究. 生物医学工程学杂志 2009; 26(2):351-355.
70. 孟洁, 杨曼, 王超英, 孔桦, 王睿, 王琛, 解思深, 许海燕*. 水溶液中分散的多壁碳纳米管与血液蛋白质分子的作用研究. 新型炭材料 2007; 22(3): 218-226.
71. 孟洁, 宋礼, 孔桦, 王朝英, 解思深, 许海燕*. 血浆蛋白分子在单壁碳纳米管无纺膜表面吸附行为的研究. 生物医学工程学杂志 2007; 24(1): 55-60.
72. 郭小天, 孟洁, 孔桦, 宋礼, 王朝英, 何朝辉, 许海燕*, 解思深. 单壁碳纳米管无纺膜表面的PEG修饰及蛋白质吸附研究. 中国生物医学工程学报 2006; 24(6): 438-441.
第二部分：生物材料与组织工程/再生医学
Part 2: Biomaterials & regenerative medicine
1. Xuechun Hu#, Fei Zeng#, Yin Yang, Boya Hao, Lihong Sun, Tao Wang, Jian Liu*, Haiyan Xu *. Injectable enzyme-crosslinking antioxidant hydrogel for stem cells protection and application in skeletal muscle regeneration. Chemical Engineering Journal 503 (2025) 158135.
2. Tao Guo, Xuechun Hu, Zhe Du, Xiuqi Wang, Jinghe Lan1, Jian Liu, Haiyan Xu* and Zhijing Sun1*. Modification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation. Journal of Nanobiotechnology (2024) 22: 598.
3. Jie Meng#, Bo Xiao#, Fengxin Wu#, Lihong Sun, Bo Li, Wen Guo, Xuechun Hu, Xuegai Xu, Tao Wen, Jian Liu*, Haiyan Xu*. Co-axial fibrous scaffolds integrating with carbon fiber promote cardiac tissue regeneration post myocardial infarction. Materials Today Bio. 2022; 16(5): 100415
4. Hu X, Liu W, Sun L, Xu S, Wang T, Meng J, Wen T, Liu Q, Liu J*, Xu H*. Magnetic Nanofibrous Scaffolds Accelerate the Regeneration of Muscle Tissue in Combination with Extra Magnetic Fields. Int J Mol Sci. 2022 Apr 18; 23(8): 4440.
5. 校搏, 胡雪纯, 刘健, 黄宇光, 许海燕*. 皮下植入聚乳酸/明胶/碳纤维多孔导电凝胶的生物相容性研究. 北京生物医学工程2023; 42(4): 355-360.
6. 郝博雅, 曾菲, 温涛, 孟洁, 许海燕*, 刘健*. 咖啡酸改性明胶水凝胶制备及其抗氧化功能. 基础医学与临床2022; 42(7): 1035-1041.
7. 刘青桥, 郝博雅, 刘文昊, 童元建, 周航, 刘健, 许海燕. 碳纤维/磁性纳米颗粒/高分子共轴纤维复合支架构建及其对成纤维细胞的作用研究. 北京生物医学工程2022; 41(1):1-7.
8. 校搏, 许仕琳, 吴凤新, 刘煊欣, 黄宇光, 许海燕*. 导电性聚乙烯醇复合水凝胶对巨噬细胞和血管内皮细胞的作用研究. 中国生物医学工程学报2022; 41(6): 717-723.
9. 赖馨宁, 校博, 黄宇光, 许海燕, 许力*, 刘健*. 导尿管表面局麻药物缓释涂层的形成及其镇痛效果研究. 中国生物医学工程学报2021；40(6): 82-88.
10. 徐学盖, 吴凤新, 高爱军, 孟洁, 温涛, 刘健, 徐樑华*, 许海燕*. 三维多孔电磁复合支架构建与理化表征. 中国生物医学工程学报，2019; 38(4): 447-453.
11. Hao S#, Zhang Y#, Meng J, Liu J, Wen T, Gu N*, Xu H*. Integration of a Superparamagnetic Scaffold and Magnetic Field to Enhance the Wound-Healing Phenotype of Fibroblasts. ACS Appl Mater Interfaces 2018 Jul 11; 10(27): 22913-22923.
12. Fengxin Wu#, Aijun Gao#, Jian Liu, Yaoyi Shen, Panpan Xu, Jie Meng, Tao Wen, Lianghua Xu*, Haiyan Xu*. High modulus conductive hydrogels enhance in vitro maturation and contractile function of primary cardiomyocytes for uses in drug screening. Advanced Healthcare Materials 2018 Nov 28; Doi/10.1002/adhm.201800990
13. Suisui Hao#, Yaoyi Shen#, Haoan Wu#, Jie Meng, Lifei Xie, Tao Wen, Ning Gu, Jian Liu*, Yu Zhang,* Haiyan Xu*. Modulatory Effects of the Composition and Structure on the Osteogenic Enhancement for Superparamagnetic Scaffolds. Eng. Sci., 2018; 4, 100-110. DOI: 10.30919/es8d782 (Front cover)
14. Hao S#, Meng J#, Zhang Y, Liu J, Nie X, Wu F, Yang Y, Wang C*, Gu N*, Xu H*. Macrophage phenotypic mechanomodulation of enhancing bone regeneration by superparamagnetic scaffold upon magnetization. Biomaterials 2017; 140:16-25.
15. 校搏，郝绥绥，吴凤新，孟洁，张宇，刘健，黄宇光，顾宁，许海燕*. 磁响应性三元复合材料制备及引导骨缺损修复的研究. 中国生物医学工程学报2015; 34(3):330-336.
16. Meng J#, Xiao B#, Zhang Y, Liu J, Xue H, Lei J, Kong H, Huang Y, Jin Z, Gu N*, Xu H*. Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo. Sci Rep. 2013; 3:2655.
17. Meng J, Cheng X, Kong H, Yang M, Xu H*. Preparation and biocompatibility evaluation of polyurethane filled with multiwalled carbon nanotubes. J Nanosci Nanotechnol. 2013; 13(2): 1467-1471.
18. Meng J#, Zhang Y#, Qi X, Kong H, Wang C. Xu Z. Xie S, Gu N* Xu H*. Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells. Nanoscale 2010; 2(12): 2565-2569.
19. Meng J#, Han Z#, Kong H, Qi X, Wang C, Xie S, Xu H*. Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function. J Biomed Mater Res A. 2010; 95(1): 312-320
20. Meng J#, Kong H#, Han Z, Wang C, Zhu G, Xie S, Xu H*. Enhancement of nanofibrous scaffold of MWNTs/polyurethane composite to the fibroblasts growth and biosynthesis. J Biomed Mater Res A 2009; 88(1): 105-116.
21. Han Z, Kong H, Meng J, Wang C, Xie S, Xu H*. Electrospinning of aligned Carbon nanotubes-Polyurethane composite scaffold for endothelial cells growth. J Nanosci Nanotech 2009; 9(2): 1400-1402
22. Meng J, Song L, Meng J, Kong H, Zhu G, Wang C, Xu L, Xie S, Xu H*. Using single-walled carbon nanotubes nonwoven films as scaffolds to enhance long-term cell proliferation in vitro. J Biomed Mater Res A. 2006; 79(2): 298-306
23. Xu H, Kaar JL, Russell AJ, Wagner WR*. Characterizing the modification of surface proteins with poly (ethylene glycol) to interrupt platelet adhesion. Biomaterials 2006; 27(16): 3125-3135.
24. Meng J, Kong H, Xu HY*, Song L, Wang CY, Xie SS. Improving the blood compatibility of polyurethane using carbon nanotubes as fillers and its implications to cardiovascular surgery. J Biomed Mater Res A. 2005; 74(2): 208-14.
25. Meng J, Song L, Xu H*, Kong H, Wang C, Guo X, Xie S. Effects of single-walled carbon nanotubes on the functions of plasma proteins and potentials in vascular prostheses. Nanomedicine: Nanotechnology, Biology, and Medicine 2005; 1(2): 136-142.
26. 孟洁, 郭小天, 孔桦, 杨曼, 许振, 许海燕*. 碳纳米管/聚氨酯复合材料的制备及生物相容性评价. 基础医学与临床 2010; 30(9): 897-901.
27. 齐晓谨, 孟洁, 孔桦, 吴晓春*, 许海燕*. 表面纳微米沟槽结构对成纤维细胞黏附和骨架重排的促进作用. 中国生物医学工程学报2009; 27(12): 899-903.
28. 韩昭昭, 孔桦, 孟洁, 王超英, 朱广瑾, 解思深, 许海燕*. 取向纳米纤维支架引导内皮细胞生长的作用研究. 高等学校化学. 2008; 29(5): 1070-1073.
29. 孟洁，孔桦，韩昭昭，王朝英，朱广瑾，解思深，许海燕*. 聚氨酯/碳纳米管复合材料电纺丝支架对成纤维细胞生长的促进. 中国组织工程与临床康复2008; 12(49): 9691-9694.
30. 孟洁, 宋礼, 孔桦, 王朝英, 朱广瑾, 徐樑华, 解思深, 许海燕*. 细胞在单壁碳纳米管无纺膜支架上的生长行为. 高等学校化学学报2007; 28(4): 476-480
31. 孟洁, 宋礼, 孔桦, 王朝英, 郭小天, 许海燕*, 解思深. 单壁碳纳米管无纺膜的抗凝血性能及其对血液系统中植入性假体的意义. 新型碳材料2004; 19(3):166-170.
32. 许海燕, 孔桦, 杨子彬*. 利用等离子体表面接枝技术提高医用聚氨酯血液相容性的研究. 中国生物医学工程学报2003; 22(6): 533-536
33. 许海燕，孔桦，杨子彬*. 聚氨酯/碳纳米纤维复合材料的结构和抗凝血性能. 材料研究学报2003; 17(2): 127-131.
34. 许海燕*, 孔桦, 蔺嫦燕, 李冰一. 聚氨酯/纳米碳复合材料表面的血液相容性研究. 中国医学科学院学报2002; 24(2): 114-7
35. 孔桦, 许海燕*, 蔺嫦燕, 李冰一, 王景. 纳米碳改性聚氨酯复合材料的表面抗凝血性能.基础医学与临床2002; 22(2): 113-116
36. Xu H, Kong H, Yang Z*. The Preparation of Nanoscale Composite of Polyurethane to Decrease Platelet Deposition on the Surface. Chinese Journal of Biomedical Engineering （English Edition）2001; 10(4): 1941. Xuechun Hu#, Fei Zeng#, Yin Yang, Boya Hao, Lihong Sun, Tao Wang, Jian Liu*, Haiyan Xu *. Injectable enzyme-crosslinking antioxidant hydrogel for stem cells protection and application in skeletal muscle regeneration. Chemical Engineering Journal 503 (2025) 158135.
2. Tao Guo, Xuechun Hu, Zhe Du, Xiuqi Wang, Jinghe Lan1, Jian Liu, Haiyan Xu* and Zhijing Sun1*. Modification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation. Journal of Nanobiotechnology (2024) 22: 598.
3. Jie Meng#, Bo Xiao#, Fengxin Wu#, Lihong Sun, Bo Li, Wen Guo, Xuechun Hu, Xuegai Xu, Tao Wen, Jian Liu*, Haiyan Xu*. Co-axial fibrous scaffolds integrating with carbon fiber promote cardiac tissue regeneration post myocardial infarction. Materials Today Bio. 2022; 16(5): 100415
4. Hu X, Liu W, Sun L, Xu S, Wang T, Meng J, Wen T, Liu Q, Liu J*, Xu H*. Magnetic Nanofibrous Scaffolds Accelerate the Regeneration of Muscle Tissue in Combination with Extra Magnetic Fields. Int J Mol Sci. 2022 Apr 18; 23(8): 4440.
5. 校搏, 胡雪纯, 刘健, 黄宇光, 许海燕*. 皮下植入聚乳酸/明胶/碳纤维多孔导电凝胶的生物相容性研究. 北京生物医学工程2023; 42(4): 355-360.
6. 郝博雅, 曾菲, 温涛, 孟洁, 许海燕*, 刘健*. 咖啡酸改性明胶水凝胶制备及其抗氧化功能. 基础医学与临床2022; 42(7): 1035-1041.
7. 刘青桥, 郝博雅, 刘文昊, 童元建, 周航, 刘健, 许海燕. 碳纤维/磁性纳米颗粒/高分子共轴纤维复合支架构建及其对成纤维细胞的作用研究. 北京生物医学工程2022; 41(1):1-7.
8. 校搏, 许仕琳, 吴凤新, 刘煊欣, 黄宇光, 许海燕*. 导电性聚乙烯醇复合水凝胶对巨噬细胞和血管内皮细胞的作用研究. 中国生物医学工程学报2022; 41(6): 717-723.
9. 赖馨宁, 校博, 黄宇光, 许海燕, 许力*, 刘健*. 导尿管表面局麻药物缓释涂层的形成及其镇痛效果研究. 中国生物医学工程学报2021；40(6): 82-88.
10. 徐学盖, 吴凤新, 高爱军, 孟洁, 温涛, 刘健, 徐樑华*, 许海燕*. 三维多孔电磁复合支架构建与理化表征. 中国生物医学工程学报，2019; 38(4): 447-453.
11. Hao S#, Zhang Y#, Meng J, Liu J, Wen T, Gu N*, Xu H*. Integration of a Superparamagnetic Scaffold and Magnetic Field to Enhance the Wound-Healing Phenotype of Fibroblasts. ACS Appl Mater Interfaces 2018 Jul 11; 10(27): 22913-22923.
12. Fengxin Wu#, Aijun Gao#, Jian Liu, Yaoyi Shen, Panpan Xu, Jie Meng, Tao Wen, Lianghua Xu*, Haiyan Xu*. High modulus conductive hydrogels enhance in vitro maturation and contractile function of primary cardiomyocytes for uses in drug screening. Advanced Healthcare Materials 2018 Nov 28; Doi/10.1002/adhm.201800990
13. Suisui Hao#, Yaoyi Shen#, Haoan Wu#, Jie Meng, Lifei Xie, Tao Wen, Ning Gu, Jian Liu*, Yu Zhang,* Haiyan Xu*. Modulatory Effects of the Composition and Structure on the Osteogenic Enhancement for Superparamagnetic Scaffolds. Eng. Sci., 2018; 4, 100-110. DOI: 10.30919/es8d782 (Front cover)
14. Hao S#, Meng J#, Zhang Y, Liu J, Nie X, Wu F, Yang Y, Wang C*, Gu N*, Xu H*. Macrophage phenotypic mechanomodulation of enhancing bone regeneration by superparamagnetic scaffold upon magnetization. Biomaterials 2017; 140:16-25.
15. 校搏，郝绥绥，吴凤新，孟洁，张宇，刘健，黄宇光，顾宁，许海燕*. 磁响应性三元复合材料制备及引导骨缺损修复的研究. 中国生物医学工程学报2015; 34(3):330-336.
16. Meng J#, Xiao B#, Zhang Y, Liu J, Xue H, Lei J, Kong H, Huang Y, Jin Z, Gu N*, Xu H*. Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo. Sci Rep. 2013; 3:2655.
17. Meng J, Cheng X, Kong H, Yang M, Xu H*. Preparation and biocompatibility evaluation of polyurethane filled with multiwalled carbon nanotubes. J Nanosci Nanotechnol. 2013; 13(2): 1467-1471.
18. Meng J#, Zhang Y#, Qi X, Kong H, Wang C. Xu Z. Xie S, Gu N* Xu H*. Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells. Nanoscale 2010; 2(12): 2565-2569.
19. Meng J#, Han Z#, Kong H, Qi X, Wang C, Xie S, Xu H*. Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function. J Biomed Mater Res A. 2010; 95(1): 312-320
20. Meng J#, Kong H#, Han Z, Wang C, Zhu G, Xie S, Xu H*. Enhancement of nanofibrous scaffold of MWNTs/polyurethane composite to the fibroblasts growth and biosynthesis. J Biomed Mater Res A 2009; 88(1): 105-116.
21. Han Z, Kong H, Meng J, Wang C, Xie S, Xu H*. Electrospinning of aligned Carbon nanotubes-Polyurethane composite scaffold for endothelial cells growth. J Nanosci Nanotech 2009; 9(2): 1400-1402
22. Meng J, Song L, Meng J, Kong H, Zhu G, Wang C, Xu L, Xie S, Xu H*. Using single-walled carbon nanotubes nonwoven films as scaffolds to enhance long-term cell proliferation in vitro. J Biomed Mater Res A. 2006; 79(2): 298-306
23. Xu H, Kaar JL, Russell AJ, Wagner WR*. Characterizing the modification of surface proteins with poly (ethylene glycol) to interrupt platelet adhesion. Biomaterials 2006; 27(16): 3125-3135.
24. Meng J, Kong H, Xu HY*, Song L, Wang CY, Xie SS. Improving the blood compatibility of polyurethane using carbon nanotubes as fillers and its implications to cardiovascular surgery. J Biomed Mater Res A. 2005; 74(2): 208-14.
25. Meng J, Song L, Xu H*, Kong H, Wang C, Guo X, Xie S. Effects of single-walled carbon nanotubes on the functions of plasma proteins and potentials in vascular prostheses. Nanomedicine: Nanotechnology, Biology, and Medicine 2005; 1(2): 136-142.
26. 孟洁, 郭小天, 孔桦, 杨曼, 许振, 许海燕*. 碳纳米管/聚氨酯复合材料的制备及生物相容性评价. 基础医学与临床 2010; 30(9): 897-901.
27. 齐晓谨, 孟洁, 孔桦, 吴晓春*, 许海燕*. 表面纳微米沟槽结构对成纤维细胞黏附和骨架重排的促进作用. 中国生物医学工程学报2009; 27(12): 899-903.
28. 韩昭昭, 孔桦, 孟洁, 王超英, 朱广瑾, 解思深, 许海燕*. 取向纳米纤维支架引导内皮细胞生长的作用研究. 高等学校化学. 2008; 29(5): 1070-1073.
29. 孟洁，孔桦，韩昭昭，王朝英，朱广瑾，解思深，许海燕*. 聚氨酯/碳纳米管复合材料电纺丝支架对成纤维细胞生长的促进. 中国组织工程与临床康复2008; 12(49): 9691-9694.
30. 孟洁, 宋礼, 孔桦, 王朝英, 朱广瑾, 徐樑华, 解思深, 许海燕*. 细胞在单壁碳纳米管无纺膜支架上的生长行为. 高等学校化学学报2007; 28(4): 476-480
31. 孟洁, 宋礼, 孔桦, 王朝英, 郭小天, 许海燕*, 解思深. 单壁碳纳米管无纺膜的抗凝血性能及其对血液系统中植入性假体的意义. 新型碳材料2004; 19(3):166-170.
32. 许海燕, 孔桦, 杨子彬*. 利用等离子体表面接枝技术提高医用聚氨酯血液相容性的研究. 中国生物医学工程学报2003; 22(6): 533-536
33. 许海燕，孔桦，杨子彬*. 聚氨酯/碳纳米纤维复合材料的结构和抗凝血性能. 材料研究学报2003; 17(2): 127-131.
34. 许海燕*, 孔桦, 蔺嫦燕, 李冰一. 聚氨酯/纳米碳复合材料表面的血液相容性研究. 中国医学科学院学报2002; 24(2): 114-7
35. 孔桦, 许海燕*, 蔺嫦燕, 李冰一, 王景. 纳米碳改性聚氨酯复合材料的表面抗凝血性能.基础医学与临床2002; 22(2): 113-116
36. Xu H, Kong H, Yang Z*. The Preparation of Nanoscale Composite of Polyurethane to Decrease Platelet Deposition on the Surface. Chinese Journal of Biomedical Engineering （English Edition）2001; 10(4): 194
第三部分：纳米材料毒理学与临床安全应用
Part 3 Biological Effects of nanomaterials and safety application
1. Zhang X, Kong F, Wang T, Huang X, Li W, Zhang M, Wen T, Liu J, Zhang Y, Meng J, Xu H. Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis. Nanotoxicology. 2023 Jan 20:1-15. doi: 10.1080/17435390.2022.2154176.
2. Yang A, Wen T*, Hao B, Meng Y, Zhang X, Wang T, Meng J, Liu J, Wang J, Xu H*. Biodistribution and Toxicological Effects of Ultra-Small Pt Nanoparticles Deposited on Au Nanorods (Au@Pt NRs) in Mice with Intravenous Injection. International Journal of Nanomedicine 2022, 17, 5339-5351.
3. Ruan L, Lu L, Zhao X, Xiong W, Xu H*, Wu S*. Effects of natural antioxidants on the oxidative stability of Eucommia ulmoides seed oil: Experimental and molecular simulation investigations. Food Chem. 2022 Jul 30; 383:132640.
4. Zhang S, Zhang X, Meng J, Lu L, Du S, Xu H*, Wu S*. Study on the Effect of Polymer Excipients on the Dispersibility, Interaction, Solubility, and Scavenging Reactive Oxygen Species of Myricetin Solid Dispersion: Experiment and Molecular Simulation. ACS Omega. 2022 Jan 3; 7(1): 1514-1526.
5. Geng H, Ren Y, Qin G, Wen T*, Liu Q, Xu H, He W*. Ti3C2 nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress. RSC Adv. 2022 Apr 8; 12(18): 11128-11138.
6. Xie Q#, Wen T#, Yang A, Zhang X, Chen B, Meng J, Liu J, Gu N*, Xu H*. A Contrast Examination of Proinflammatory Effects on Kidney Function for γ-Fe2O3 NP and Gadolinium Dimeglumine. Int J Nanomedicine. 2021; 16: 2271-2282.
7. 张雪, 孔非, 温涛, 张宇, 许海燕, 孟洁. 氧化铁纳米颗粒引起肝血窦内皮细胞损伤及其机制研究. 中国生物医学工程学报2021, 40(5): 582-589
8. Li H#, Wen T#, Wang T, Ji Y, Shen Y, Chen J, Xu H*, Wu X*. In Vivo Metabolic Response upon Exposure to Gold Nanorod Core/Silver Shell Nanostructures: Modulation of Inflammation and Upregulation of Dopamine. International Journal of Molecular Sciences. 2020; 21 2: 384.
9. Lu L, Luo K, Yang W, Zhang S, Wang W, Xu H, Wu S. Insight into the anti-aging mechanisms of natural phenolic antioxidants in natural rubber composites using a screening strategy based on molecular simulation. RSC Adv. 2020 Jun 4; 10(36): 21318-21327.
10. Wen T#, Du L#, Chen B, Yan D, Yang A, Liu J, Gu N, Meng J*, Xu H*. Iron oxide nanoparticles induce reversible endothelial-to-mesenchymal transition in vascular endothelial cells at acutely non-cytotoxic concentrations. Part Fibre Toxicol. 2019 Jul 12; 16(1): 30.
11. Wen T#, Yang A#, Piao L, Hao S, Du L, Meng J, Liu J, Xu H*. Comparative study of in vitro effects of different nanoparticles at non-cytotoxic concentration on the adherens junction of human vascular endothelial cells. Int J Nanomedicine. 2019 Jun 18; 14: 4475-4489.
12. Tao Wen#, Doudou Yan#, Jie Meng, Jian Liu and Haiyan Xu*. The Enzyme-Like Property and Photocatalytic Effect on α, α-Diphenyl-b-Picrylhydrazyl (DPPH) of CuPt Nanocomposite. Catalysts 2019, 9, 813; doi:10.3390/catal9100813
13. 杨爱云#, 温涛#, 武昊安, 苗玉清, 孟洁, 刘健, 张宇, 樊海明, 许海燕*. 不同磁性纳米材料对血管内皮细胞作用的对比研究. 北京生物医学工程2018; 37 (3): 235-240.
14. 杜丽帆 张宇 杨爱云 温涛 刘健 孟洁 许海燕. 二巯基丁二酸修饰的Fe3O4纳米颗粒对人血管内皮细胞的作用研究. 北京生物医学工程2019；38（3）：221-226.
15. Yang M#, Nie X#, Meng J*, Liu J, Sun Z, Xu H*. Carbon Nanotubes Activate Limulus Amebocyte Lysate Coagulation by Interface Adsorption. ACS Appl Mater Interfaces. 2017 Mar 15; 9(10): 8450-8454.
16. Lin CX, Yang SY, Gu JL, Meng J, Xu HY, Cao JM*. The acute toxic effects of silver nanoparticles on myocardial transmembrane potential, I(Na) and I(K1) channels and heart rhythm in mice. Nanotoxicology. 2017 Aug 23:1-11.
17. Li H, Tan XQ, Yan L, Zeng B, Meng J, Xu HY, Cao JM*. Multi-walled carbon nanotubes act as a chemokine and recruit macrophages by activating the PLC/IP3/CRAC channel signaling pathway. Sci Rep. 2017; 7(1): 226.
18. Guo H#, Zhang J#, Boudreau M, Meng J, Yin JJ, Liu J*, Xu H*. Intravenous administration of silver nanoparticles causes organ toxicity through intracellular ROS-related loss of inter-endothelial junction. Part Fibre Toxicol. 2016; 13:21.
19. Wen T, Zhang H, Chong Y, Wamer WG, Yin JJ, Wu, X*. Probing hydroxyl radical generation from H2O2 upon Plasmon excitation of gold nanorods using electron spin resonance: Molecular oxygen-mediated activation. Nano Res. 2016; 9:1663.
20. Meng J, Ji Y, Liu J, Cheng X, Guo H, Zhang W, Wu X*, Xu H*. Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice. Nanotoxicology 2014; 8(6): 686-696
21. Tan XQ#, Cheng XL#, Zhang L, Wu BW, Liu QH, Meng J, Xu HY, Cao JM*. Multi-walled carbon nanotubes impair Kv4.2/4.3 channel activities, delay membrane repolarization and induce bradyarrhythmias in the rat. PLoS One 2014; 9(7): e101545.
22. Yang N#
主要学习、工作经历： 本科和研究生毕业于中国科技大学应用化学系，1985年获理学学士学位，1988年获理学硕士学位。1988-1995年在北京化工大学高分子科学与工程系工作。1995年加入中国医学科学院基础医学研究所生物医学工程系。曾于1994年在日本大阪市立工业技术研究所研修（JICA项目）；1999-2000年在美国匹兹堡大学McGowan Institute of Regenerative Medicine（McGowan再生医学研究院）William R. Wagner实验室工作，从事生物材料表面分子修饰与抗凝血功能研究。 主要社会兼职： 中国生物医学工程学会理事/纳米医学与工程分会主委（2023-）/女科技工作者委员会主任委员（2019-）、Committee member of WiMBE, IFMBE（国际医学与生物工程联合会）（2023-）、 中国生物物理学会理事及纳米生物学分会委员、中国微米纳米技术学会纳米科学技术分会常务理事、北京生物医学工程学会常务理事、全国专业标准化技术委员会委员及“健康、安全与环境”工作组副组长兼秘书长、《基础医学与临床》、《中国生物医学工程学报》、《国际生物医学工程学杂志》和《北京生物医学工程》编辑委员会委员。
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