"主持多项国自然基金项目，包括国自然专项、重大研究计划培育、国际合作、面上项目等。在Cancer cell、Nat Immunol、Nat Cell Biol、Nat Biomed Eng、Sci Immunol、Cell Res、J Clin Invest、Nat Commun、Cancer Res 、EMBO J、Nuc Acid Res等国际主流杂志上以通讯作者或第一作者（共同）发表多篇研究论文，引用2600多次。 课题组具有丰富的肿瘤学、免疫学、生物力学研究经验，主攻肿瘤免疫、生物力学肿瘤免疫、肿瘤免疫治疗方向，通过学科交叉研究，从免疫学、生物力学角度等探究肿瘤发生发展的分子机理以及肿瘤与免疫微环境的互作，以期探寻全新的肿瘤免疫疗法。"

代表性论文 (仅列出近五年通讯或第一（共同）作者的学术论文)

Jiadi Lv, Yuying Liu, Siqi Mo, Yabo Zhou, Fengye Chen, Feiran Cheng, Cong Li, Dilizhatai Saimi, Mengyu Liu, Huafeng Zhang, Ke Tang, Jingwei Ma, Zhenfeng Wang, Qiangqiang Zhu, Wei-Min Tong & Bo Huang. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway. Nat Cell Biol. 2022;24:364–372. (IF=28.824)

Liu Y, Zhou N, Zhou L, Wang J, Zhou Y, Zhang T, Fang Y, Deng J, Gao Y, Liang X, Lv J, Wang Z, Xie J, Xue Y, Zhang H, Ma J, Tang K, Fang Y, Cheng F, Zhang C, Dong B, Zhao Y, Yuan P, Gao Q, Zhang H, Xiao-Feng Qin F, Huang B.. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor. Nat Immunol. 2021;22(3):358-369. (IF=25.606)

Lv J, Liu Y, Cheng F, Li J, Zhou Y, Zhang T, Zhou N, Li C, Wang Z, Ma L, Liu M, Zhu Q, Liu X, Tang K, Ma J, Zhang H, Xie J, Fang Y, Zhang H, Wang N, Liu Y*, Huang B*. Cell softness regulates tumorigenicity and stemness of cancer cells. EMBO J. 2021;40:e106123. (IF=11.598)

Liu Y*, Zhang T, Zhang H, Li J, Zhou N, Fiskesund R, Chen J, Lv J, Ma J, Zhang H, Tang K, Cheng F, Zhou Y, Zhang X, Wang N, Huang B*. Cell softness prevents cytolytic T cell killing of tumor-repopulating cells. Cancer Res. 2021;81:476-488. (IF=12.701)

Lv J, Yu P, Wang Z, Deng W, Bao L, Liu J, Li F, Zhu Q, Zhou N, Lv Q, Wang G, Wang S, Zhou Y, Song J, Tong WM, Liu Y*, Qin C*, Huang B*. ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques. Cell Mol Immunol. 2021;18(5):1308-1310. (IF=11.53)

Lv J, Wang Z, Qu Y, Zhu H, Zhu Q, Tong W, Bao L, Lv Q, Cong J, Li D, Deng W, Yu P, Song J, Tong WM, Liu J*, Liu Y*, Qin C*, Huang B*. Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 aleolar macrophages. Cell Discov. 2021;7:24. (IF=10.849)

Liu Y, Lv J, Liu J, Li M, Xie J, Lv Q, Deng W, Zhou N, Zhou Y, Song J, Wang P, Qin C, Tong WM, Huang B. Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19. Cell Res. 2020;30:1078-1087. (IF=25.617)

Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y*, Wang X*, Huang B*. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020;4:743-753. (IF=25.671)

Liu Y, Fang Y, Chen X, Wang Z, Liang X, Zhang T, Liu M, Zhou N, Lv J, Tang K, Xie J, Gao Y, Cheng F, Zhou Y, Zhang Z, Hu Y, Zhang X, Gao Q, Zhang Y, Huang B. Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 2020;5(43):eaax7969. (IF=17.727)

Liu Y. et al. Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy. Cell Mol Immunol. 2019;16:611-620. (IF=8.484)

Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Xiao-Feng Qin F, Huang B. Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation. Cancer Cell 2018;33:480-494. (IF= 31.743)

Liu Y, Lv J, Liu J, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX, Huang B. STAT3/p53 pathway activation disrupts IFN-beta-induced dormancy in tumor-repopulating cells. J Clin Invest. 2018;128:1057-1073. (IF=14.808)

Liu Y, Lv J, Liang X, Yin X, Zhang L, Chen D, Jin X, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Xie J, Wang N, Huang B. Fibrin Stiffness Mediates Dormancy of Tumor-Repopulating Cells via a Cdc42-Driven Tet2 Epigenetic Program. Cancer Res. 2018;78:3926-3937. (IF=12.701)

Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin X, Chen D, Li Y, Zhang S, Xie HQ, Zhao B, Zhao T, Lu J, Hu ZW, Cao X, Qin FX, Huang B. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-gamma-induced immunologic dormancy of tumor-repopulating cells. Nat Commun 2017;8:15207. (IF=14.919)

基金申请

(1) 国家自然科学基金专项基金，82341009，机械信号通路PIEZO1-GRHL3抑制T细胞介导的抗肿瘤生物力学研究，2023-03至2026-02，142万，在研，主持

(2) 国家自然科学基金重大培育项目，92169101，新冠肺炎治疗新策略：细胞微颗粒递送病毒进入肺泡巨噬细胞降解，2022-01至2024-12，62万，在研，主持

(3) 国家自然科学基金国际合作项目，82061148014，干性肿瘤细胞利用物理软性逃避T细胞杀伤机制与治疗策略，2020-10至2023-09，200万， 在研，主持

(4) 国家自然基金面上项目，81773062，IFN-β激活IDO1-Kyn-AhR信号通路调节肿瘤再生细胞休眠；2018-01-01至2021-12-31，58万元，已结题，主持

(5) 中国医学科学院医学与健康科技创新工程项目-新型冠状病毒肺炎科研攻关先导专项，2020-I2M-CoV19-007，新冠病毒触发炎症风暴的机制研究，2020-06至2021-12，150万元，已结题，主持

获得学术奖励

中国医学科学院北京协和医学院科 青年创新奖

专利申请（已经授权）

(1) 检测Kyn含量的试剂的应用

(2) 一种采用原子力显微镜检测细胞表面孔洞的方法

(3) Method for detecting cell surface holes using atomic force microscope

(4) 一种含有转运蛋白抑制剂的药物、药物组合物及用途

刘玉英，中国医学科学院基础医学研究所药理系，研究员，博士生导师。博士毕业于中国医学科学院药物研究所；毕业后在美国南卡罗莱纳州医科大学进行博士后，从事肿瘤治疗研究；回国后加入中国医学科学院基础医学研究所