个人简介：程涛，男，1963年8月出生，农工民主党党员，北京协和医学院长聘教授，中国生理学会副理事长，《Blood Science》主编。1981-1989年就读于第二军医大学，获医学硕士学位（血液内科）；1993年赴美国，先后在Hipple癌症研究中心、哈佛医学院、麻省总医院等机构学习和工作；2001-2013年就职于美国匹兹堡大学癌症研究所，逐步晋升为终聘正教授；2007年7月引进回国，获教育部“长江学者”特聘教授，任中国医学科学院血液病医院（中国医学科学院血液学研究所）常务副所院长；2008年始任实验血液学国家重点实验室（2023年重组为血液与健康全国重点实验室）主任；2012年创建北京协和医学院干细胞与再生医学系并担任系主任；2019年10月至今担任中国医学科学院血液病医院（中国医学科学院血液学研究所）所院长。2021年1月至今兼任中国医学科学院基础医学研究所（北京协和医学院基础学院）所院长。

研究方向及学术贡献：程涛教授深耕血液学和再生医学38年。针对放化疗、骨髓移植或严重核辐射损伤所致造血障碍难题，聚焦造血干细胞（HSC），取得系列原创发现：创立“干细胞效能”学说，发现具有超级移植效能的HSC，并揭示其失能关键机制；提出“血液生态”概念，解码其形成与重塑规律，制定血液生态重建新策略并获临床验证；建立修复冻存脐血造血活性新方法，开发新型造血细胞系列产品，拓展临床应用场景。主持国家重大科研和人才项目17项，发表SCI论文315篇，入选科睿唯安“全球高被引科学家”和“全球前2%顶尖科学家”，授权发明专利40项，转化合同总金额过亿元，荣获国家自然科学二等奖、全国创新争先奖、天津市自然科学特等奖等奖项。建立全球最大骨髓活细胞库和血液病大数据中心，领衔打造我国北方最大细胞与基因治疗产品孵化基地，带领医院蝉联血液学专科声誉和血液病学科技量值榜首，成为全球最大血液病诊疗和再生医学中心，为我国血液学与再生医学的发展作出突出贡献。

1.Dong F, Hao S, Zhang S, Zhu CY, Cheng H, Yang ZN, Fiona K. Hamey4, Wang XF, Gao A, Wang FJ, GaoY, Dong J, Wang CC, Wang JY, Lan Y, Liu B, Hideo Ema, Fuchou Tang FC, Berthold Gottgens, Zhu P, Cheng T. Differentiation of transplanted haematopoietic stem cells tracked by single cell transcriptomic analysis. Nat Cell Biol. 2020 Jun; 22(6):630-639.

2. Xie XW, Liu MY, Zhang YW, Wang BR, Zhu CY, Wang CC, Li Q, Huo YY, Guo JJ, Xu CL, Hu LP, Pang AM, Ma SH, Wang LN, Wenbin Cao, Zhang SD , Zhao XY, Zhou W, Luo HB, Zheng GG, Jiang E, Feng SZ, Shi LH, Cheng H, Hao S, Zhu P, Cheng T. The Single-cell Transcriptome Landscape of Human Blood Cells. National Science Review, 2020 July 31 (in press).

3. Huang D, Sun GH, Hao XX, He XX, Zheng ZF, Chen CQ, Yu Z, Xie L, MaSH, Liu LG, Zhou B, Cheng H*, Zheng JK*, Cheng T*. ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. Journal of clinical investigation. 2020.Oct doi: 10.1172/JCI138986.

4. Zhang C, Xu ZH, Yang SD, Sun GH, Jia LM, Zheng ZF, Gu Q, Tao W, Cheng T*, Li C, Cheng H. tagHi-C Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis.Cell Rep. 2020 Sep 29; 32:108206.

5. Xia C, Wang T, Cheng H, Dong Y, Weng Q, Sun G, Zhou P, Wang K, Liu X, Geng Y, Ma S, Hao S, Xu L, Guan Y, Du J, Du X, Li Y, Zhu X, Shi Y, Xu S, Wang D, Cheng T, Wang J. Mesenchymal stem cells suppress leukemia via macrophagemediated functional restoration of bone marrow microenvironment. Leukemia. 2020 Feb 24; doi.org/10.1038/s41375-020-0775-3.

6.Wang Y, Lu T, Sun G, Zheng Y, Yang S, Zhang H, Hao S, Liu Y, Ma S, Zhang H, Ru Y, Gao S, Yen K, Cheng H, Cheng T. Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells. Nat Commun. 2019 Dec 6;10(1):5594.

7.Zhang JP, Cheng XX, Zhao M, Li GH, Xu J, Zhang F, Yin MD, Meng FY, Dai XY, Fu YW, Yang ZX, Arakaki C, Su RJ, Wen W, Wang WT, Chen W, Choi H, Wang C, Gao G, Zhang L, Cheng T, Zhang XB. Curing hemophilia A by NHEJ mediated ectopic F8 insertion in the mouse. Genome Biol. 2019 Dec 16;20(1):276.

8.Li XL, Li GH, Fu J, Fu YW, Zhang L, Chen W, Arakaki C, Zhang JP, Wen W, Zhao M, Chen WV, Botimer GD, Baylink D, Aranda L, Choi H, Bechar R, Talbot P, Sun CK, Cheng T, Zhang XB. Highly efficient genome editing via CRISPR Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression. Nucleic Acids Res. 2018 Nov 2;46(19):10195-10215.

9.Zhang JP, Li XL, Li GH, Chen W, Arakaki C, Botimer GD, Baylink D, Zhang L, Wen W, Fu YW, Xu J, Chun N, Yuan W, Cheng T, Zhang XB. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9 mediated double stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35.

10. Lim M, Pang Y, Ma S, Hao S, Shi H, Zheng Y, Hua C, Gu X, Yang F, Yuan W, Cheng T. Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow. Leukemia.2016 Jan;30(1):154-62.

11. Wang Y, Gao A, Zhao H, Lu P, Cheng H, Dong F, Gong Y, Ma S, Zheng Y, Zhang H, Zhang Y, Xu J, Zhu X, Yuan W, Zhang X, Hao S, Cheng T. Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3. Leukemia. 2016 Sep;30(9):1897-908.

12. Cheng H, Liu Y, Jia Q, Ma S, Yuan W, Jia H, Cheng T. Novel regulators in hematopoietic stem cells can be revealed by a functional approach under leukemic condition. Leukemia. 2016 Oct;30(10):2074-2077.

13. Zheng Y, Zhang H, Wang Y, Li X, Lu P, Dong F, Pang Y, Ma S, Cheng H, Hao S, Tang F, Yuan W, Zhang X, Cheng T. Loss of Dnmt3b accelerates MLL-AF9 leukemia progression. Leukemia. 2016 Dec;30(12):2373-2384.

14. Wen W, Zhang JP, Xu J, Su RJ, Neises A, Ji GZ, Yuan W, Cheng T, Zhang XB. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors. Stem Cell Reports. 2016 Jun 14;6(6):873-84.

15.Cheng H, Hao S, Liu Y, Pang Y, Ma S, Dong F, Xu J, Zheng G, Li S, Yuan W, Cheng T. Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation. Blood. 2015 Sep 10;126(11):1302-1.

16.Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF, Xiao G, Yuan W, Liu B, Cheng T. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 2015 Nov 19;126(21):2383-91.

17.Gao Y, Yang P, Shen H, Yu H, Song X, Zhang L, Zhang P, Cheng H, Xie Z, Hao S, Dong F, Ma S, Ji Q, Bartlow P, Ding Y, Wang L, Liu H, Li Y, Cheng H, Miao W, Yuan W, Yuan Y, Cheng T, Xie XQ. Small molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells. Nat Commun. 2015 Feb 18;6:6328.

18.Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z, Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G, Cheng T, Wang QF. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 2014 Mar;46(3):287-93.

19. Hu L, Cheng H, Gao Y, Shi M, Liu Y, Hu Z, Xu J, Qiu L, Yuan W, Leung AY, Yang YG, Cheng T. The antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice. Blood. 2014 Nov 13;124(20):e45-8.

20. Liu Y, Cheng H, Gao S, Zou Z, He F, Hu L, Hou D, Lu X, Li Y, Zhang H, Xu J, Kang L, Wang Q, Yuan W, Gao S, Cheng T. Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. Leukemia. 2014 May;28(5):1071-80.

21. Ma S, Shi Y, Pang Y, Dong F, Cheng H, Hao S, Xu J, Zhu X, Yuan W, Cheng T, Zheng G. Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen. J Hematol Oncol. 2014 Nov 4;7(1):71.

22.Li Y, Feng H, Gu H, Lewis D, Yuan Y, Zhang L, Yu H, Zhang P, Cheng H, Miao W, Yuan W, Cheng S, Gollin S, Cheng T. The p53 PUMA axis suppresses iPSC generation. Nat Commun. 2013;4:2174.

23.Yuan W, Sipp D, Wang ZZ, Deng H, Pei D, Zhou Q, Cheng T. Stem Cell Science on the Rise in China. Cell Stem Cell. 2012. Jan;10(1):12-15.

24.Shen H, Yu H, Liang PH, Cheng H, Xufeng R, Yuan Y, Zhang P, Smith CA, Cheng T. An acute negative bystander effect of γ irradiated recipients on transplanted hematopoietic stem cells. Blood. 2012 Apr 12;119(15):3629-37.

25.Li Y, Liu Y, He J, Wang F, Liu S, Zhang Y, Kou Z, Ju Z, Zheng G, Xu J, Yuan W, Gao S, Cheng T. Long term survival of exogenous embryonic stem cells in adult bone marrow. Cell Res. 2011 Jul;21(7):1148-51.

26.Yu H, Shen H, Xiaochun Ping, Feng Xu, Xiaoxia Hu, Yanxin Li, Yun Ling, Jian Yu, Lin Zhang, Sean P. Garrison, Gerard P Zambetti and Cheng T. Deletion of PUMA protects hematopoietic stem cells and confers long term survival in response to high dose r-irradiation. Blood. 2010 Apr 29;115(17):3472-80.

27.XuFeng R, Boyer MJ, Shen H, Li Y, Yu H, Gao Y, Yang Q, Wang Q, Cheng T. ADAR1 is required for survival of hematopoietic progenitors but not primitive stem cells via RNA editing. Proc Natl Acad Sci USA. 2009 Oct 20; 106(42): 17763-17768.

28. Hu X, Shen H, Tian C, Yu H, Zheng G, Xu F, Ju Z, Xu J, Wang J, Cheng T. Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-indeuced leukemia model. Blood. 2009 Oct 29; 114(18):3783-92.

29.Yu H, Yuan Y, Shen H, Cheng T. Hematopoietic stem cell exhaustion impacted by p18 and p21 in opposite manners. Blood. 2006; 107(3):1200-6.

30.Sung L, Gao S, Shen H, Yu H, Song Y, Smith S, Chang C, Inoue, Kuo L, Lian J, Li A, Tian X, Tuck D, Weissman S, Yang X, Cheng T. Differentiated cells are more efficient than adult stem cells as donors for cloning by somatic cell nuclear transfer. Nat Genet. 2006 Nov; 38(11):1323-8.

31.Yuan Y, Yu H, Boyer M, Shen H, Cao S,Cheng T. Hematopoietic stem cells are not the direct target of spontaneous leukemic transformation in p18(INK4C) null reconstituted mice. Cancer Res. 2006 Jan;24(1):48-52.

32.Yuan Y, Shen H, Franklin DS, Scadden DT,Cheng T. In vivo self renewing divisions of hematopoietic stem cells in vivo are increased in the absence of the early G1 phase inhibitor, p18INK4c. Nat Cell Biol. 2004; 6(5): 436-42.

33. Cheng T, Shen H, Rodrigues N, Stier S and Scadden DT. Transforming growth factor beta1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1). Blood. 2001 Dec 15; 98(13):3643-3649.

34.Cheng T, Rodrigues N, Dombkowski D, Stier S and Scadden DT. Stem cell repopulation efficiency but not pool size is governed by p27(kip1). Nat Med. 2000 Nov;6(11):1235-40.

35. Cheng T, Rodrigues N, Shen H, Yong guang Yang, Dombkowski D, Sykes M and Scadden DT. Hematopoietic stem cell quiescence in vivo is maintained by p21. Science. 2000; 287: 1804-1808.

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