张宏冰是美国宾夕法尼亚大学（University of Pennsylvania）医学院博士, 哈佛大学医学院博士后、讲师。从2006年以来，任中国医学科学院-北京协和医学院生理学博士生导师，医学分子生物学国家重点实验室成员，美国中华医学基金会(CMB) 杰出教授，国家杰出青年科学基金获得者。Elsevier 2014-2020年中国高被引学者（Most Cited Chinese Researchers）。现在是中国医学科学院-北京协和医学院长聘教授。
目前研究方向：研究细胞信号传导的调节，探讨疾病的发生机制、早期诊断和靶向治疗，为促进基础医学到临床医学的转化、疾病的精准治疗提供依据。
张宏冰发表的代表性论文：
1. Meng Y, Zheng C, Zhang X, Gao Z, Chen H, Qi X, Li K, Liu F, Deng W, Wu Y, Liu J, Chen C, Wang C, Zhao H, Zhang H. xCT/Slc7a11 promotes pulmonary arterial hypertension by disrupting AMPKα suppression of mTOR activation. Biochem Pharmacol. 2025 Jun;236:116897.
2. Wang H, Hu D, Cheng C, Zhang X, Liu J, Tian X, Zhang H, Xu KF. Synergistic effects of mTOR inhibitors with VEGFR3 inhibitors on the interaction between TSC2-mutated cells and lymphatic endothelial cells. Sci China Life Sci. 2025 Jun;68(6):1676-1688.
3. Gai X, Liu F, Chen Y, Zhang B, Zhang Y, Wu Y, Yang S, Chen L, Deng W, Wang Y, Wang S, Yu C, Du J, Zhang Z, Wang J, Zhang H. GOLM1 Promotes Atherogenesis by Activating Macrophage EGFR-ERK Signaling Cascade. Circ Res. 2025 Apr 11;136(8):848-861.
4. Zhang B, Gai X, Tang B, Chen L, Wu Y, Deng W, Liu J, Hao L, Liu F, Zhang H. Oncogenic β-catenin stimulation of cofilin 1-mediated macropinocytosis is druggable for cancer. Theranostics. 2025 Mar 17;15(9):4176-4187.
5. Lv J, Wang Y, Lv J, Zheng C, Zhang X, Wan L, Zhang J, Liu F, Zhang H. Pifithrin-μ sensitizes mTOR-activated liver cancer to sorafenib treatment. Cell Death Dis. 2025 Jan 26;16(1):42.
6. Zhang X, Liu S, Yang L, Cheng C, Wang H, Hu D, Zhang X, Zhang M, Liu Y, Tian X, Zhang H, Xu KF. Omics research in lymphangioleiomyomatosis: status and challenges. Expert Rev Respir Med. 2024 Oct;18(10):805-814.
7. Huang F, Guo J, Zhao N, Hou M, Gai X, Yang S, Cai P, Wang Y, Ma Q, Zhao Q, Li L, Yang H, Jing Y, Jin D, Hu Z, Zha X, Wang H, Mao Y, Liu F, Zhang H. PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1. J Transl Med. 2024 Mar 8;22(1):254.
8. Wang Y, Hu D, Wan L, Yang S, Liu S, Wang Z, Li J, Li J, Zheng Z, Cheng C, Wang Y, Wang H, Tian X, Chen W, Li S, Zhang J, Zha X, Chen J, Zhang H, Xu KF. GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1. Am J Respir Cell Mol Biol. 2024 Mar;70(3):178-192.
9. Liu F, Wu Y, Zhang B, Yang S, Shang K, Li J, Zhang P, Deng W, Chen L, Zheng L, Gai X, Zhang H. Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis. Chin Med J (Engl). 2024 Jan 20;137(2):181-189.
10. Huang F, Zhao N, Cai P, Hou M, Yang S, Zheng B, Ma Q, Jiang J, Gai X, Mao Y, Wang L, Hu Z, Zha X, Liu F, Zhang H. Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer. Transl Res. 2024 Jan 18:S1931-5244(24)00014-8.
11. Gao Z, Zheng C, Xing Y, Zhang X, Bai Y, Chen C, Zheng Y, Wang W, Zhang H, Meng Y. Polo-like kinase 1 promotes sepsis-induced myocardial dysfunction. Int Immunopharmacol. 2023 Dec;125(Pt A):111074.
12. Chen R, Wang H, Zheng C, Zhang X, Li L, Wang S, Chen H, Duan J, Zhou X, Peng H, Guo J, Zhang A, Li F, Wang W, Zhang Y, Wang J, Wang C, Meng Y, Du X, Zhang H. Polo-like kinase 1 promotes pulmonary hypertension. Respir Res. 2023 Aug 19;24(1):204.
13. Jiang D, Xiao H, Zheng X, Dong R, Zhang H, Dai H. Interleukin-17A plays a key role in pulmonary fibrosis following Propionibacterium acnes-induced sarcoidosis-like inflammation. Exp Biol Med (Maywood). 2023 Jul;248(14):1181-1190.
14. Chen Z, Yin M, Jia H, Chen Q, Zhang H. ISG20 stimulates anti-tumor immunity via a double-stranded RNA-induced interferon response in ovarian cancer. Front Immunol. 2023 Jun 5;14:1176103.
15. Gai X, Liu F, Wu Y, Zhang B, Tang B, Shang K, Wang L, Zhang H, Chen Y, Yang S, Deng W, Li P, Wang J, Zhang H. Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis. Animal Model Exp Med. 2023 Apr;6(2):92-102.
16. Wu Y, Yang S, Han L, Shang K, Zhang B, Gai X, Deng W, Liu F, Zhang H. β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer. J Transl Med. 2023 Jan 26;21(1):50.
17. Liu F, Gai X, Wu Y, Zhang B, Wu X, Cheng R, Tang B, Shang K, Zhao N, Deng W, Chen J, Zhang Z, Gu S, Zheng L, Zhang H. Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2202157119.
18. Tang B, Wang Y, Xu W, Zhu J, Weng Q, Chen W, Fang S, Yang Y, Qiu R, Chen M, Mao W, Xu M, Zhao Z, Cai S, Zhang H, Ji J. Macrophage xCT deficiency drives immune activation and boosts responses to immune checkpoint blockade in lung cancer. Cancer Lett. 2022 Nov 29;554:216021.
19. Wan L, Wang Y, Li J, Wang Y, Zhang H. Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs. Acta Biochim Biophys Sin (Shanghai). 2022 Oct 25;54(11):1637-1647.
20. Han L, Wu Y, Liu F, Zhang H. eIF4A1 Inhibitor Suppresses Hyperactive mTOR-associated Tumors by Inducing Necroptosis and G2/M Arrest. Int. J. Mol. Sci. 2022 Jun 22;23(13):6932.
21. Zhang X, Zheng C, Gao Z, Chen H, Li K, Wang L, Zheng Y, Li C, Zhang H, Gong M, Zhang H, Meng Y. SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis. Cardiovasc Drugs Ther. 2022 Jun;36(3):437-447.
22. Dai Y, Zhang X, Lv J, Feng F, Wan X, Huang F, Zhang H, Zhu L. Familial uterine leiomyoma-associated germline oncogenic mutant VEGFR1 is sensitive to mTOR inhibitor. Sci Bull (Beijing). 2022 Mar 30;67(6):585-587.
23. Zhou X, Sun Z, Zhang M, Qu X, Yang S, Wang L, Jing Y, Li L, Deng W, Liu F, Di J, Chen J, Wu J, Zhang H. Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation. Animal Model Exp Med. 2022 Feb;5(1):61-71.
24. Wan LY, Peng H, Ni YR, Jiang XP, Wang JJ, Zhang YQ, Ma L, Li R, Han L, Tan Y, Li JM, Cai WL, Yuan WF, Liang JJ, Huang L, Wu X, Zhou Q, Cheng QN, Yang X, Liu MY, Ai WB, Liu CB, Zhang H, Wu JF. The miR-23b/27b/24-1 cluster inhibits hepatic fibrosis by inactivating hepatic stellate cells. Cell Mol Gastroenterol Hepatol. 2022;13(5):1393-1412.
25. Wang L, Wang F, Liu K, Long C, Chen Y, Li C, Li L, Liu F, Zhang X, Jing Y, Wang Y, Liang A, Yan H, Zhang H. αB-crystallin/HSPB2 is critical for hyperactive mTOR-induced cardiomyopathy. J Cell Physiol. 2021 Dec;236(12): 8110-8121.
26. Wang Y, Hu S, Shen L, Liu S, Wan L, Yang S, Hou M, Tian X, Zhang H, Xu KF. Dynamic Observation of Autophagy and Transcriptome Profiles in a Mouse Model of Bleomycin-Induced Pulmonary Fibrosis. Front Mol Biosci. 2021 Jul 29;8:664913.
27. Nie M, Yu B, Chen R, Sun B, Mao J, Wang X, Zhang H, Wu X. Novel rare variants in FGFR1 and clinical characteristics analysis in a series of congenital hypogonadotropic hypogonadism patients. Clin Endocrinol (Oxf). 2021 Jul;95(1):153-162.
28. 王 莹，张宏冰。第3章（pp47-59） mTOR信号通路调节自噬，自噬生物学与疾病基础卷（第3版），科学出版社，2021.
29. Zhou J, Zhao Z, Sun T, Liu W, Yu Z, Liu J, Yu Y, Ning S, Zhang H. Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study. Am J Gastroenterol. 2021 May 1;116(5):1044-1052.
30. Pu Y, Song Y, Zhang M, Long C, Li J, Wang Y, Xu Y, Pan F, Zhao N, Zhang X, Xu Y, Cui J, Wang H, Li Y, Zhao Y, Jin D, Zhang H. GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis. Signal Transduct Target Ther. 2021 Apr 14;6(1):148.
31. Wan X, Zhou M, Huang F, Zhao N, Chen X, Wu Y, Zhu W, Ni Z, Jin F, Wang Y, Hu Z, Chen X, Ren M, Zhang H, Zha X. AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development. Cell Death Dis. 2021 Feb 10;12(2):172.
32. Nie M, Yu B, Chen R, Sun B, Mao J, Wang X, Zhang H, Wu X. Novel rare variants in FGFR1 and clinical characteristics analysis in a series of congenital hypogonadotropic hypogonadism patients. Clin Endocrinol (Oxf). 2021 Jul;95(1):153-162.
33. Gao Y, Ma X, Bi J, Chu J, Liu B, Chi C, Yan J, Yu X, Liu F, Deng X, Zhang H, Jin B. Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history. Virulence. 2020 Dec;11(1):1015-1023.
34. Liu Z, Mao J, Xu H, Wang X, Huang B, Zheng J, Nie M, Zhang H, Wu X. Gonadotropin-induced Spermatogenesis in CHH Patients with Cryptorchidism. Int J Endocrinol. 2019 Dec 18;2019:6743489.
35. Li C, Chen H, Lan Z, He S, Chen R, Wang F, Liu Z, Li K, Cheng L, Liu Y, Sun K, Wan X, Chen X, Peng H, Li L, Zhang Y, Jing Y, Huang M, Wang Y, Wang Y, Jiang J, Zha X, Chen L, Zhang H. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis. Cell Death Differ. 2019 Oct;26(10):2015-2028.
36. Wang Y, Zhang H. Regulation of Autophagy by mTOR Signaling Pathway. Adv Exp Med Biol. 2019;1206:67-83.
37. 吴玉婷，马茜，汤步富，刘芳铭，靳迪，王玲，盖晓晨，张宏冰。氯化锂对第10号染色体缺失的磷酸酶及张力蛋白同源基因缺失肿瘤的疗效分析 [J] . 中华医学杂志, 2019,99( 30 ): 2362-2366.
38. Gai X, Tang B, Liu F, Wu Y, Wang F, Jing Y, Huang F, Jin D, Wang L, Zhang H. miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3β/MMPs. J Genet Genomics. 2019 May 20;46(5):235-245.
39. 徐凯峰，金美玲，刘杰，欧阳若芸，田欣伦，张波，张宏冰，中华医学会呼吸病学分会间质性肺疾病学组。西罗莫司治疗淋巴管肌瘤病专家共识(2018)。中华结核和呼吸杂志,2019,42( 2 ): 92-97。
40. 王 莹，张宏冰。第三章 mTOR 信号与自噬调节，自噬生物学与疾病基础卷，科学出版社，2019
41. Hu D, Mao Y, Xu G, Liao W, Ren J, Yang H, Yang J, Sun L, Chen H, Wang W, Wang Y, Sang X, Lu X, Zhang H, Zhong S. Time-restricted feeding causes irreversible metabolic disorders and gut microbiota shift in pediatric mice. Pediatr Res. 2019 Mar;85(4):518-526.
42. 王冬梅，孟真，张宏冰。雷帕霉素靶蛋白抑制剂西罗莫司治疗晚期骨髓纤维化，中华医学杂志 2018;98(2):154-155。
43. Sun Q, Li S, Wang Y, Peng H, Zhang X, Zheng Y, Li C, Li L, Chen R, Chen X, Bai W, Jiang X, Liu L, Wei F, Wang B, Zhang Y, Li H, Ren X, Zhang H. Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis. Cell Death Differ. 2018;25(6):1160-1173.
44. Xu KF, Tian X, Yang Y, Zhang H. Rapamycin for lymphangioleiomyomatosis: optimal timing and optimal dosage. Thorax. 2018 Apr;73(4):308-310.
45. Chen R, Duan J, Li L, Ma Q, Sun Q, Ma J, Li C, Zhou X, Chen H, Jing Y, Zhao S, Wu X, Zhang H. mTOR promotes pituitary tumor development through activation of PTTG1. Oncogene 2017;36(7):979-988
46. Nie M, Xu H, Chen R, Mao J, Wang X, Xiong S, Zheng J, Yu B, Cui M, Ma W, Huang Q, Zhang H, Wu X. Analysis of genetic and clinical characteristics of a Chinese Kallmann syndrome cohort with ANOS1 mutations. Eur J Endocrinol. 2017:177(4):389-398.
47. Huang F, Cai P, Wang Y, Zhou X, Chen H, Liao W, Mao Y, Zha X, Zhang H, Hu Z. Up-regulation of brain-expressed X-linked 2 is critical for hepatitis B virus X protein-induced hepatocellular carcinoma development. Oncotarget 2017; 8:65789-65799
48. Liu KM, Zhang HH, Wang YN, Wang LM, Chen HY, Long CF, Zhang LF, Zhang HB, Yan HB. Wild-type p53-induced Phosphatase 1 Deficiency Exacerbates Myocardial Infarction-induced Ischemic Injury. Chin Med J (Engl). 2017;130(11):1333-1341.
49. Liu Z, Mao J, Wu X, Xu H, Wang X, Huang B, Zheng J, Nie M, Zhang H. Efficacy and Outcome Predictors of Gonadotropin Treatment for Male Congenital Hypogonadotropic Hypogonadism. Medicine 2016;95(9):e2867.
50. Wang L, Zhang H, Li C, Yi Y, Liu J, Zhao Y, Tian J, Zhang Y, Wei X, Gao Y, Liang A. Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. PLoS One 2016;11(10):e0164215.
51. Liao W, Yang H, Xu H, Wang Y, Ge P, Ren J, Xu W, Lu X, Sang X, Zhong S, Zhang H, Mao Y. Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing. Oncotarget. 2016; 7(26):40481-40490.
52. Hu Z, Yang A, Fan H, Wang Y, Zhao Y, Zha X, Zhang H, Tu P. Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling. J Ethnopharmacol. 2016;186:143-50.
53. Chen X, Wang Y, Tao J, Shi Y, Gai X, Huang F, Ma Q, Zhou Z, Chen H, Zhang H, Liu Z, Sun Q, Peng H, Chen R, Jing Y, Yang H, Mao Y, Zhang H. mTORC1 Upregulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice. Gastroenterology. 2015;149(3):741–752.
54. Hu Z, Wang Y, Huang F, Chen R, Li C, Wang F, Goto J, Kwiatkowski DJ, Wdzieczak-Bakala J, Tu P, Liu J, Zha X, Zhang H. Brain Expressed X-Linked 2 Is Pivotal for Hyperactive mTOR-mediated Tumorigenesis. J Biol Chem. 2015; 290 (42):25756-65.
55. Chen R, Li S, Liu G, Yuan Y, Liu J, Liu T, Wu R, Sun Q, Ren X, Yi X, Zhang H. Digital karyotyping with whole genome sequencing for complex congenital disorder. J Genet Genomics. 2015; 42 (11):651-5
56. Jin D, Tao J, Li D, Wang Y, Li L, Hu ZD, Zhou ZZ, Chang XL, Qu CF, Zhang H. Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion. Oncotarget. 2015; 6 (32):33523-33.
57. 茅江峰，陈蓉蓉，伍学焱，刘兆祥，郑俊杰，王曦，聂敏，段婧，张宏冰。先天性低促性腺激素性性腺功能减退症男性患者的性腺轴外表现和致病基因间的关系。中华医学杂志2015; 95:3424-7.
58. Zha X, Hu Z, Ji S, Jin F, Jiang K, Li C, Zhao P, Tu Z, Chen X, Di L, Zhou H, Zhang H. NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth. Cancer Lett. 2015; 359:97-106
59. Mao JF, Xu HL, Duan J, Chen RR, Li L, Li B, Nie M, Min L, Zhang HB, Wu XY. Reversal of idiopathic hypogonadotropic hypogonadism: a cohort study in Chinese patients. Asian J Androl. 2015; 17:497-502.
60. Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H. PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade. J Biol Chem. 2014; 289 (43):29739-49 (Paper of the Week).
61. Wang F, Chen X, Li C, Sun Q, Chen Y, Wang Y, Peng H, Liu Z, Chen R, Liu K, Yan H, Ye BH, Kwiatkowski DJ, Zhang H. Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex. Oncogene. 2014; 33(34):4352-8.
62. Liu Z, Xu KF, Hu C, Chen R, Duan J, Shi Y, Wang Y, Zhang W, Moss J, Wu J, Zhang H. Use of whole-exome sequencing for the diagnosis of atypical Birt-Hogg-Dubé syndrome. J Genet Genomics. 2014; 41(8): 449-151
63. Ma A, Wang L, Gao Y, Chang Z, Peng H, Zeng N, Gui YS, Tian X, Li X, Cai B, Zhang H, Xu KF. Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality. Hum Mol Genet. 2014; 23: 693-705
64. Chen Y, Wang F, Li C, Wang L, Zhang H, Yan H. Acquired cardiomyopathy caused by cardiac Tsc1 deficiency. J Genet Genomics. 2014; 41: 73-7
65. Wang Y, Hu Z, Liu Z, Chen R, Peng H, Guo J, Chen X, Zhang H. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy. 2013;9(12):2069-86.
66. Peng H, Liu J, Sun Q, Chen R, Wang Y, Duan J, Li C, Bin Li, Jing Y, Chen X, Mao Q, Xu KF, Walker CL, Li J, Wang J, Zhang H. mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development. Oncogene. 2013; 32(39):4702-11.
67. Li H, Wang J, Xu H, Xing R, Pan Y, Li W, Cui J, Zhang H, Lu Y. Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells. Mol Cancer. 2013; 12(1):110
68. Dai C, Zhang B, Liu X, Ma S, Yang Y, Yao Y, Feng M, Bao X, Li G, Wang J, Guo K, Ma W, Xing B, Lian W, Xiao J, Cai F, Zhang H, Wang R. Inhibition of PI3K/AKT/mTOR pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude mice. Endocrinology. 2013; 154: 1247-1259.
69. Gui YS, Wang L, Tian X, Ma A, Cai B, Zhang H, Xu KF. SPC-Cre-ERT2 transgenic mouse used for temporal gene deletion in mouse alveolar epithelial cells. PLoS One 2012；7: e46076
70. He J, Kang L, Wu T, Zhang J, Wang H, Gao H, Zhang Y, Huang B, Liu W, Kou Z, Zhang H, Gao S. An elaborate regulation of mTOR activity is required for somatic cell reprogramming induced by defined transcription factors. Stem Cells Dev. 2012; 21: 2630-41.
71. Zhang L, Zhang H, Li L, Xiao Y, Rao E, Miao Z, Chen H, Sun L, Li H, Liu G, Zhao Y. TSC1/2 Signaling complex is essential for peripheral naïve CD8 T cell survival and homeostasis in mice. PLoS One. 2012; 7: e30592.
72. Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4129-34.
73. Ma J, Sun Q, Mi R, Zhang H. Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling. J Genet Genomics. 2011, 38: 533-7.
74. Zha X, Hu Z, He S, Wang F, Shen H, Zhang H. TSC1/TSC2 inactivation inhibits AKT through mTORC1-dependent up-regulation of STAT3-PTEN cascade. Cancer Lett. 2011, 313: 211-7.
75. Tian X, Shao C, Feng R, Xu K, Zhang H. Expiratory lymphatic sacs. Am J Respir Crit Care Med. 2011, 184: 1085.
76. Wu XN, Wang XK, Wu SQ, Lu J, Zheng M, Wang YH, Zhou H, Zhang H, Han J. Phosphorylation of raptor by p38β participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. J Biol Chem. 2011, 286:31501-11.
77. Sun Y, Yang H, Mao Y, Xu H, Zhang J, Li G, Lu X, Sang X, Zhao H, Zhong S, Huang J, Zhang H. Increased GP73 expression in hepatocellular carcinoma tissue correlates with tumor aggression but not survival. J Gastroenterol Hepatol. 2011, 26:1207-12.
78. Zha X, Sun Q, Zhang H. mTOR upregulation of glycolytic enzymes promotes tumor development. Cell Cycle 2011, 10: 1015-6
79. Zha X, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H. Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis. Cancer Res. 2011, 71; 13–8.
80. 陈旺、杨华瑜、毛一雷、张锦春、徐海峰、蒋桂勇、井艳玲、陈欣欣、卢欣、桑新亭、钟守先、黄洁夫、张宏冰. 高尔基体蛋白73单克隆抗体在肝细胞肝癌诊断中的价值。中国医学科学院学报2011, 33; 39-44.
81. Mao Y, Yang H, Xu H, Lu X, Sang X, Du S, Zhao H, Chen W, Xu Y, Chi T, Yang Z, Cai J, Li H, Chen J, Zhong S, Mohanti SR, Lopez-Soler R, Millis JM, Huang J, Zhang H. Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma. Gut. 2010, 59:1687-93.
82. Ma J, Meng Y, Kwiatkowsk DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, Zhang S, Chen R, Wang L, Wu E, Cai G, Malinowska-Kolodziej I, Liao Q, Liu Y, Zhao Y, Sun Q, Xu K, Dai J, Han J, Wu L, Zhao RC, Shen H, Zhang H. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest. 2010, 120: 103-14.
83. Mi R, Ma J, Zhang D, Li L, Zhang H. Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model. J Genet Genomics. 2009, 36:355-61.
84. Wu E, Palmer N, Tian Z, Moseman AP, Galdzicki M, Wang X, Berger B, Zhang H, Kohane IS. Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PLoS One. 2008, 3: e3794.
85. 毛一雷、杨华瑜、徐海峰、桑新亭、卢欣、杨志英、张锦春、钟守先、黄洁夫、张宏冰. 新的肝癌血清标记物GP73在肝癌诊断中的初步研究。 中华医学杂志 2008，88：948-51
86. Zhang J., B. Wang, Z. Xiao, Y. Zhao, B. Chen, J. Han, Y. Gao, W. Ding，Zhang H, J. Dai. Olfactory ensheathing cells promote proliferation and inhibit neuronal differentiation of neural progenitor cells through activation of Notch1. Neuroscience 2008, 153: 406-13.
87. Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ. PDGF receptors are critical for PI3K/AKT activation and negatively regulated by mTOR. J Clin Invest. 2007, 117: 730-8.
88. Lee L, Sudentas P, Donohue B, Asrican K, Worku A, Walker V, Sun Y, Schmidt K, Albert MS, El-Hashemite N, Lader AS, Onda H, Zhang H, Kwiatkowski DJ, Dabora SL. Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer. 2005, 42: 213-27.
89. Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropath Exp Neur. 2004, 63:1236-42.
90. El-Hashemite N, Zhang H, Walker V, Hoffmeister KM, Kwiatkowski DJ. Perturbed IFNg-Jak-stat signaling in tuberouse sclerosis mouse models: synergistic effects of rapamycin-IFNg treatment. Cancer Res. 2004, 64: 3436-43.
91. Finlay GA, York B, Karas RH, Fanburg BL, Zhang H, Kwiatkowski DJ, Noonan DJ. Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2. J Biol Chem 2004, 279: 23114-22
92. Zhang H, Cicchetti G, Onda H, Koon HB, Asrikan K, Bajraszewski N, Vazquez P. Carpenter C, Kwiatkowski DJ. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signalling through downregulation of PDGFR. J Clin Invest. 2003, 112: 1223-33.
93. El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ. Loss of tuberous sclerosis complex genes induces vascular endothelial growth factor production through mTOR pathway. Cancer Res. 2003, 63: 5173-7.
94. El-Hashemite N, Zhang H, Henske EP, Kwiatkowski DJ. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet. 2003, 361: 1348-9.
95. Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet. 2002, 11: 525-34.
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